Cyclotron And Radiochemistry Laboratory

Cyclotron And Radiochemistry Laboratory company information, Employees & Contact Information

The Cyclotron and Radiochemistry Laboratory (CARL) at King’s College London is the UK’s first nationally-accessible research-dedicated facility for radionuclide production and radiopharmaceutical chemistry. Refurbished with a £1m EPSRC grant (June 2022) enabling the upgrade of equipment infrastructure and management of the facility, CARL has been open since March 2023. CARL provides facilities for radionuclide production including target design and preparation, cyclotron irradiation (on site, or elsewhere e.g. via direct collaboration with the Birmingham Cyclotron Facility), target radionuclide purification, and radiochemistry development/radiopharmaceutical synthesis. Available radionuclides will include those in routine use (18F, 11C, 13N, 64Cu) and radionuclides of research interest, which are otherwise not produced in UK (currently 62Cu, 62Zn, 44Sc, and 52Mn). In the next years 124I, 203Pb, 94mTc, and 211At will be available. CARL offers the following support to users and collaborators: • Access and use of equipment including an 11 MeV cyclotron, high purity germanium detector (HPGe), ICP-OES, 6 hot cells/shielded fume hoods, radiosynthesis and radioanalytical modules, training and support from local staff • A pipeline to on-site preclinical in vitro and in vivo research with tracers developed in CARL • Support for writing joint grant proposals (in collaboration with Department of Imaging Chemistry and Biology) to sustainably fund CARL • Supply and shipment of radionuclides and/or radiotracers • Sample analysis e.g. trace metal analysis on ICP-OES • Use of CARL space for teaching and training e.g. hosting hands-on equipment workshops Interested users should contact the facility (carlfacility@kcl.ac.uk) to discuss research needs and project proposals, access, charges, training, or supply of radionuclides across the UK and overseas.
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