Drugtrain Itn

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DRUGtrain (DRUG repurposing and discovery multidisciplinary training network) will create a European innovative, multidisciplinary and intersectoral training program to provide Early Stage Reseachers (PhD students) from diverse backgrounds with a broad, interdisciplinary perspective and intersectoral approach for drug discovery. In this context, DRUGtrain offers a timely paradigm for multidisciplinary research, ideal for improving drug repurposing and discovery strategies of compounds, with autosomal dominant polycystic kidney disease (ADPKD) as example. ADPKD is one of the most common causes of renal failure. The difficulty in identifying drugs for ADPKD treatment can be partially attributed to the lack of understanding of the functions of the PKD1- and PKD2-proteins, and on how inactivation of these two trans-membrane proteins leads to cyst development. The identification of more and better drugs for ADPKD requires a multidisciplinary and macro-level approach. Therefore, repositioning of drugs that are on the market for other diseases is probably the fastest approach to bring new therapies to the clinic. ADPKD is a good paradigm for the development of new drugs combining various approaches, including repurposing and drug discovery.
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