Fulcrum Neuroscience

We are dedicated to preventing age-related cognitive decline, such as Alzheimer’s Disease. The Fulcrum Neuroscience platform enables a new approach to neurodegenerative disease drug discovery. We are generating deep insights into disease pathology and variability in diverse populations. Our work is driving novel biomarker characterization and innovative strategies for stabilizing brain energy metabolism, including new drugs. At the heart of the Fulcrum platform is a computer model of Brain Health and Neurodegeneration coupled with a digital twin generator. Digital twins can be used to simulate whole populations, to analyze how new drugs may behave in a clinical trial, or to simulate an individual’s risk of disease and how to best prevent or treat it. Analysis of each digital twin provides tangible, explainable insights that help researchers and physicians provide at-risk patients the chance for additional years of cognitive health, enhancing quality of life, reducing family caregiving burdens, and reducing total medical costs. We won’t stop until we live in a world without cognitive decline.