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) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII Nature

Structure-based discovery of highly bioavailable, covalent, broad-spectrum coronavirus M Science | AAAS

/TMPRSS2 bispecific inhibitor with potent anti-coronavirus efficacy in vivo Nature

Exploring Possible Drug-Resistant Variants of SARS-CoV-2 Main Protease (M ACS Publications

by Natural and Synthetic Inhibitors: Potential Implication for Vaccine Production Against COVID-19 Frontiers

Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus | Communications Medicine Nature

) by repurposing/designing drug-like substances and utilizing nature’s toolbox of bioactive compounds ScienceDirect.com

Aspirus UP hospitals, clinics receive 2019 Governor’s Award of Excellence for quality, patient safety Upper Michigan's Source

Accelerating the Hit-To-Lead Optimization of a SARS-CoV-2 Mpro Inhibitor Series by Combining High-Throughput Medicinal Chemistry and Computational Simulations ACS Publications

Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro Science | AAAS

Integrating Chemo- and Bioinformatics with In Vitro Biological Assays to Discover Potential ACE2 and Mpro Inhibitors against SARS-CoV-2 ACS Publications

SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model Science | AAAS

responds to oxidation by forming disulfide and NOS/SONOS bonds Nature

High-Resolution Substrate Specificity Profiling of SARS-CoV-2 Mpro; Comparison to SARS-CoV Mpro ACS Publications

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors Nature

SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals | ACS Central Science ACS Publications

inhibition by benzisoselenazolones and diselenides Nature

Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay Nature

causes microvascular brain pathology by cleaving NEMO in brain endothelial cells Nature

inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron Nature

Targeting the Main Protease (Mpro, nsp5) by Growth of Fragment Scaffolds Exploiting Structure-Based Methodologies ACS Publications

active site cavity revealed by room temperature X-ray crystallography Nature

A potential allosteric inhibitor of SARS-CoV-2 main protease (Mpro) identified through metastable state analysis Frontiers

Garbage in, garbage out: how reliable training data improved a virtual screening approach against SARS-CoV-2 MPro Frontiers

Discovery of PLpro and Mpro Inhibitors for SARS-CoV-2 ACS Publications

Design and Optimization of Novel Competitive, Non-peptidic, SARS-CoV-2 Mpro Inhibitors ACS Publications

Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 M Nature

SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging | Nature Chemical Biology Nature

Crystallization of Feline Coronavirus Mpro With GC376 Reveals Mechanism of Inhibition Frontiers

Exploration of SARS-CoV-2 Mpro Noncovalent Natural Inhibitors Using Structure-Based Approaches ACS Publications

Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting Mpro and Ameliorates Pulmonary Inflammation Frontiers

Computational Repurposing of Drugs and Natural Products Against SARS-CoV-2 Main Protease (M Frontiers

A genetically encoded BRET-based SARS-CoV-2 Mpro protease activity sensor | Communications Chemistry Nature

) and ACE2 in Host Cells Can Be a Possible Candidate for COVID-19 Frontiers

) Activities of Flavonoids and a Sesquiterpene Lactone from Artemisia sublessingiana Wiley Online Library

Computational investigation on the antioxidant activities and on the M Frontiers

Visual Continuity of Protein Secondary Structure Rendering: Application to SARS-CoV-2 Mpro in Virtual Reality Frontiers

Potential of Plant Bioactive Compounds as SARS-CoV-2 Main Protease (M Wiley Online Library