Our founding discoveries came from the labs of Prof. Takagi and Prof Suga (the 2023 winner of the Wolf Prize in Chemistry), both of whom are deeply involved in our R&D to this day. Their innovations enable a novel class of biologics, called “Neobiologics,” that break existing boundaries in biological drug development and will ultimately better, more cost-effective treatments for patients. Internally and with our partners, we are advancing a robust portfolio of products:
1. cMet agonist to HGF (hepatocyte growth factor) to tackle NASH (non-alcoholic steatohepatitis)/fibrosis; currently in IND enabling studies.
2. TrkB agonist of BDNF (brain-derived neurotrophic factor) to tackle neurodegenerative diseases like Alzheimer's Disease and Parkinson’s Disease; currently in vivo studies.
3. Immuno-oncology bi-specific with T-cell engaging activity and a tumor antigen-specific binder; currently in vitro R&D.
4. Undisclosed assets in various stages.
This pipeline builds off our core RaPID System and LassoGraft Technology® (LGT) platforms. The RaPID System selects highly active cyclic peptides that tightly bind to drug-target proteins from our diverse library. These peptides are then genetically grafted onto scaffold proteins using LGT to create Neobiologics. Neobiologics break multiple current boundaries for biologics, such as access across the blood-brain barrier, 3D topological design control, multifunctionality (bi-specific, tri-specific, etc.), wide applicability from AAV capsid modulation to antibodies to therapeutic proteins and superior development speeds that drop development costs significantly.
Selected publications
1. Mihara, E et al. Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins. Nature Communications (2021)2:1543
2. Sakai, K et al. Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions. Nature Biomedical Engineering 7, 164-176 (2023)
Company Details
- Employees
- 6
- Founded
- -
- Address
- 4-6-1 Komaba, Komaba Open Laboratory 5f,japan
- Industry
- Pharmaceutical Manufacturing
- NAICS
-
Pharmaceutical and Medicine ManufacturingMedicinal and Botanical ManufacturingPharmaceutical Preparation ManufacturingIn-Vitro Diagnostic Substance ManufacturingBiological Product (except Diagnostic) Manufacturing
- Website
- https://www.mirabiologics.com/
- Keywords
- IT Consulting.
- HQ
- Meguro-ku, Tokyo
Mirabiologics Inc. Questions
Mirabiologics Inc.'s website is https://www.mirabiologics.com/
Mirabiologics Inc.'s LinkedIn profile is https://jp.linkedin.com/company/mirabiologics-inc
Mirabiologics Inc. has
6 employees.
View email and phone details for 6
employees at Mirabiologics Inc..
Mirabiologics Inc.'s industry is
Pharmaceutical Manufacturing
Mirabiologics Inc.'s top competitors are
Renbiologics,
Kokubu Food Create Corp.,
Telesis Therapeutics, Inc.,
加藤産業（株）,
エイベックス株式会社,
Real World Data, Co., Ltd.,
Quad.bio,
松竹芸能(株),
Hirotsuバイオサイエンス,
C.p. Intertrade Company Limited.
Mirabiologics Inc.'s categories are Pharmaceutical Manufacturing
Mirabiologics Inc.'s founding year is 2017
