The MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based at The University of Dundee, in Scotland, is a major research centre that focuses on the understanding of the biological roles of phosphorylation and ubiquitylation and how disruption of these processes cause human diseases such as neurodegeneration, cancer, hypertension and immune disorders. The ultimate goal of the Unit's research programmes is to help develop new improved strategies to treat disease.
The MRC-PPU pioneered analysis of the selectivity of protein kinase inhibitors by setting up the first service to tackle this problem in 1998. This procedure, termed "kinase profiling" proved to be of great help to the pharmaceutical industry, speeding up the development of specific protein kinase inhibitors with therapeutic potential. In keeping with its history of advancing technologies, now in 2015, the Unit will launch an effort that enables scientists around the world to interrogate a key target in the ubiquitin field -- de-ubiquitylases (DUBs), enzymes which remove ubiquitin linkages from substrates and represent an untapped target area.
A vital asset of the MRC-PPU is the Division of Signal Transduction Therapy (DSTT) which was established in 1998. This division operates as a unique collaboration between scientists in the MRC-PPU, signalling researchers at the University of Dundees College of Life Sciences and six of the worlds leading pharmaceutical companies -- AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline, Janssen Pharmaceutica, Merck Serono and Pfizer. The DSTT is widely regarded as a model for how academia should interact with industry.
Our aim for the MRC PPU is to operate as one of the world's leading centres for the investigation of signal transduction pathways involving protein phosphorylation and ubiquitylation networks. We are also keen to make our range of essential resources and services available to aide with worldwide research in this area.
Company Details
- Employees
- 58
- Founded
- -
- Address
- The University Of Dundee, James Black Centre,dow Street,united Kingdom
- Industry
- Research Services
- NAICS
-
Scientific Research and Development ServicesResearch and Development in the Physical, Engineering, and Life SciencesResearch and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
- Website
- http://www.ppu.mrc.ac.uk/
- Keywords
- Phosphorylation, Ubiquitylation, Signal Transduction, Oncology, Parkinson's Disease, Neurodegenerative Disorders, Immunology, Infectious Diseases, Cardiology.
- HQ
- Dundee
Mrc Protein Phosphorylation And Ubiquitylation Unit Questions
Mrc Protein Phosphorylation And Ubiquitylation Unit's website is http://www.ppu.mrc.ac.uk/
Mrc Protein Phosphorylation And Ubiquitylation Unit's LinkedIn profile is https://uk.linkedin.com/company/mrc-protein-phosphorylation-and-ubiquitylation-unit
Mrc Protein Phosphorylation And Ubiquitylation Unit has
58 employees.
View email and phone details for 58
employees at Mrc Protein Phosphorylation And Ubiquitylation Unit.
Mrc Protein Phosphorylation And Ubiquitylation Unit's industry is
Research Services
Mrc Protein Phosphorylation And Ubiquitylation Unit's top competitors are
School Of Life Sciences, University Of Dundee,
Wingate365,
Camgrain Stores Ltd,
Gsk,
University Of Dundee, School Of Life Sciences,
Mrc Laboratory Of Molecular Biology (Lmb),
Drug Discovery Unit, University Of Dundee,
Turku Bioscience,
Mcr Pathways,
Mrc Ppu Reagents And Services.
Mrc Protein Phosphorylation And Ubiquitylation Unit's categories are Research Services
Mrc Protein Phosphorylation And Ubiquitylation Unit's founding year is 1991
