Myc company information, Employees & Contact Information

Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis Nature

MYC deregulation makes cancer cells vulnerable to NMT inhibitors Imperial College London

Dynamic interaction of MYC enhancer RNA with YEATS2 protein regulates MYC gene transcription in pancreatic cancer EMBO Press

Targeting MYC’s Achilles heel yields new potential cancer therapies Science | AAAS

MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC Nature

When it comes to MYC, it doesn’t take much Fred Hutchinson Cancer Center

Scientists tame chaotic protein fueling 75% of cancers University of California, Riverside

MYC-Targeting Inhibitors Generated from a Stereodiversified Bicyclic Peptide Library ACS Publications

Dr Vincelette on MYC Expression in Myelofibrosis OncLive

Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy ScienceDirect.com

The 24-hour molecular landscape after exercise in humans reveals MYC is sufficient for muscle growth EMBO Press

Structural basis for nucleolin recognition of MYC promoter G-quadruplex Science | AAAS

MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages ScienceDirect.com

MYC targeting by OMO-103 in solid tumors: a phase 1 trial Nature

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion Nature

Nuclear to cytoplasmic transport is a druggable dependency in MYC-driven hepatocellular carcinoma Nature

Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity Nature

A common druggable signature of oncogenic c-Myc, mutant KRAS and mutant p53 reveals functional redundancy and competition among oncogenes in cancer | Cell Death & Disease Nature

MYC sensitises cells to apoptosis by driving energetic demand Nature

MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer Nature

Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability Nature

A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice Science | AAAS

WWOX promotes osteosarcoma development via upregulation of Myc Nature

Androgen receptor and MYC equilibration centralizes on developmental super-enhancer Nature

c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis Nature

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling Nature

MYC can’t cause havoc in B cells without MAX Fred Hutchinson Cancer Center

MYC—an emerging player in mitochondrial diseases Frontiers

MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis ScienceDirect.com

G-quadruplex DNA structure is a positive regulator of MYC transcription PNAS

MYC reshapes CTCF-mediated chromatin architecture in prostate cancer Nature

Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc Molecular Cancer

Myc plays an important role in Drosophila P-M hybrid dysgenesis to eliminate germline cells with genetic damage Nature

MYC: a multipurpose oncogene with prognostic and therapeutic implications in blood malignancies Journal of Hematology & Oncology

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation ScienceDirect.com

Targeting oncogenic Myc as a strategy for cancer treatment | Signal Transduction and Targeted Therapy Nature

Distinct functions of transforming growth factor-β signaling in c-MYC driven hepatocellular carcinoma initiation and progression Nature

A retrospective study of MYC rearranged diffuse large B-cell lymphoma in the context of the new WHO and ICC classifications | Blood Cancer Journal Nature

The Myc network’s multiple functions in spermatogenesis Fred Hutchinson Cancer Center

Going to the dark(er) side: Stanford Medicine study shows how cancer gene tricks immune cells Stanford Medicine

Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors Nature

MYC regulation of a “poor-prognosis” metastatic cancer cell state PNAS

Therapeutic targeting of “undruggable” MYC The Lancet

Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex Nature

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis ScienceDirect.com

MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability Nature

MyChart Cleveland Clinic

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation ScienceDirect.com

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells ScienceDirect.com

MYC on the Path to Cancer ScienceDirect.com

Reduced Expression of MYC Increases Longevity and Enhances Healthspan ScienceDirect.com

Targeting MYC-Driven Cancers With a Molecular Glue Degrader ASCO Daily News

Indefinite Self-Renewal of ESCs through Myc/Max Transcriptional Complex-Independent Mechanisms ScienceDirect.com

Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten PNAS