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An online GPCR drug discovery resource Nature

Prioritizing Parkinson’s disease risk genes in genome-wide association loci medRxiv

Prioritization of therapeutic targets for dyslipidemia using integrative multi-omics and multi-trait analysis ScienceDirect.com

Computational integration and meta-analysis of abandoned cardio-(vascular/renal/metabolic) therapeutics discontinued during clinical trials from 2011 to 2022 Frontiers

Empowering the discovery of novel target-disease associations via machine learning approaches in the open targets platform BMC Bioinformatics

Genetic factors associated with reasons for clinical trial stoppage Nature

Estimating the impact of single-cell RNA sequencing of human tissues on drug target validation medRxiv

Artificial intelligence in drug repurposing for rare diseases: a mini-review Frontiers

Network expansion of genetic associations defines a pleiotropy map of human cell biology Nature

Single-cell RNA sequencing of human tissue supports successful drug targets medRxiv

DrugnomeAI is an ensemble machine-learning framework for predicting druggability of candidate drug targets Nature

Exploring the Shared Genetic Architectures between Primary Open-Angle Glaucoma and Visual Pathway Regions in the Brain medRxiv

Integrative GWAS and co-localisation analysis suggests novel genes associated with age-related multimorbidity Nature

Unraveling druggable cancer-driving proteins and targeted drugs using artificial intelligence and multi-omics analyses Nature

Psychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries Nature

Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis Nature

Leveraging electronic health records and knowledge networks for Alzheimer’s disease prediction and sex-specific biological insights Nature

Expanding drug targets for 112 chronic diseases using a machine learning-assisted genetic priority score Nature

Prioritizing Parkinson’s disease risk genes in genome-wide association loci Nature

A large-scale genome-wide cross-trait analysis reveals shared genetic architecture between Alzheimer’s disease and gastrointestinal tract disorders | Communications Biology Nature

Advancing drug development for atrial fibrillation by prioritising findings from human genetic association studies The Lancet

MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis Nature

Functional studies of GWAS variants are gaining momentum Nature

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure Nature

Identifying drug targets for schizophrenia through gene prioritization medRxiv

StarGazer: A Hybrid Intelligence Platform for Drug Target Prioritization and Digital Drug Repositioning Using Streamlit Frontiers

ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon Nature

Somatic mutations in facial skin from countries of contrasting skin cancer risk Nature

Dissecting the Genetic Relationship Between Severe Mental Disorders and Autoimmune Diseases medRxiv

Automated annotation of disease subtypes ScienceDirect.com

Integrative network analysis suggests prioritised drugs for atopic dermatitis Journal of Translational Medicine

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience Nature

Drug repurposing for rare: progress and opportunities for the rare disease community Frontiers

A guide for developing comprehensive systems biology maps of disease mechanisms: planning, construction and maintenance Frontiers

Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease Nature

Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation Cell Communication and Signaling

Single-cell-led drug repurposing for Alzheimer’s disease Nature

Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4 Nature

DIRC3-IGFBP5 is a shared genetic risk locus and therapeutic target for carpal tunnel syndrome and trigger finger medRxiv

Herb-target virtual screening and network pharmacology for prediction of molecular mechanism of Danggui Beimu Kushen Wan for prostate cancer Nature