Splicebio

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SpliceBio is a biotechnology company exploiting Protein Splicing to develop the next generation of gene therapies. Our proprietary platform is based on technology developed in the Muir Lab at Princeton University after more than 20 years of pioneering intein and protein engineering research by our co-founders. The company is backed by UCB Ventures, Ysios Capital, NEA, Gilde Healthcare, Novartis Venture Fund and Asabys Partners.

Company Details

Employees
47
Address
Baldiri Reixac 10-12, Parc Cientific De Barcelona,spain
Phone
34934020456
Email
in****@****sign.es
Industry
Biotechnology
Website
splice.bio
HQ
Barcelona, Barcelona
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News

Sanofi-backed SpliceBio secures $135M series B for eye disease gene therapy trials - Fierce Biotech

Sanofi-backed SpliceBio secures $135M series B for eye disease gene therapy trials Fierce Biotech

G-Quadruplex-Based Splice Switching as a Therapeutic Approach in Duchenne Muscular Dystrophy - ACS Publications

G-Quadruplex-Based Splice Switching as a Therapeutic Approach in Duchenne Muscular Dystrophy ACS Publications

MIT biologists discover a new type of control over RNA splicing - MIT News

MIT biologists discover a new type of control over RNA splicing MIT News

Transformers significantly improve splice site prediction - Communications Biology - Nature

Transformers significantly improve splice site prediction - Communications Biology Nature

Splice Bio: gene therapies that reassemble large proteins in vivo - BioCentury

Splice Bio: gene therapies that reassemble large proteins in vivo BioCentury

Splam: a deep-learning-based splice site predictor that improves spliced alignments - Genome Biology

Splam: a deep-learning-based splice site predictor that improves spliced alignments Genome Biology

Protein Splicing of Inteins: A Powerful Tool in Synthetic Biology - Frontiers

Protein Splicing of Inteins: A Powerful Tool in Synthetic Biology Frontiers

Splice-modifying drug mechanisms - Nature

Splice-modifying drug mechanisms Nature

The role of KRAS splice variants in cancer biology - Frontiers

The role of KRAS splice variants in cancer biology Frontiers

Specific splice junction detection in single cells with SICILIAN - Genome Biology

Specific splice junction detection in single cells with SICILIAN Genome Biology

Conjugation of a Blood Brain Barrier Peptide Shuttle to an Fc Domain for Brain Delivery of Therapeutic Biomolecules - ACS Publications

Conjugation of a Blood Brain Barrier Peptide Shuttle to an Fc Domain for Brain Delivery of Therapeutic Biomolecules ACS Publications

The unusual gene architecture of polyubiquitin is created by dual-specific splice sites - Genome Biology

The unusual gene architecture of polyubiquitin is created by dual-specific splice sites Genome Biology

Programmable trans -splicing riboregulators for complex cellular logic computation - Nature

Programmable trans -splicing riboregulators for complex cellular logic computation Nature

Novel Disulfide-Bridged Bioresponsive Antisense Oligonucleotide Induces Efficient Splice Modulation in Muscle Myotubes in Vitro - ACS Publications

Novel Disulfide-Bridged Bioresponsive Antisense Oligonucleotide Induces Efficient Splice Modulation in Muscle Myotubes in Vitro ACS Publications

The physiology of alternative splicing - Nature

The physiology of alternative splicing Nature

MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data - Genome Biology

MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data Genome Biology

A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing - Nature

A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing Nature

Uncovering a multitude of stage-specific splice variants and putative protein isoforms generated along mouse spermatogenesis - BMC Genomics

Uncovering a multitude of stage-specific splice variants and putative protein isoforms generated along mouse spermatogenesis BMC Genomics

Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis - Nature

Pan-cancer pervasive upregulation of 3′ UTR splicing drives tumourigenesis Nature

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis - Nature

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis Nature

A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo - Frontiers

A Novel Splice Variant of Human TGF-β Type II Receptor Encodes a Soluble Protein and Its Fc-Tagged Version Prevents Liver Fibrosis in vivo Frontiers

MMSplice: modular modeling improves the predictions of genetic variant effects on splicing - Genome Biology

MMSplice: modular modeling improves the predictions of genetic variant effects on splicing Genome Biology

recount3: summaries and queries for large-scale RNA-seq expression and splicing - Genome Biology

recount3: summaries and queries for large-scale RNA-seq expression and splicing Genome Biology

EnsembleSplice: ensemble deep learning model for splice site prediction - BMC Bioinformatics

EnsembleSplice: ensemble deep learning model for splice site prediction BMC Bioinformatics

Splicing regulation through biomolecular condensates and membraneless organelles - Nature

Splicing regulation through biomolecular condensates and membraneless organelles Nature

SPLICE-q: a Python tool for genome-wide quantification of splicing efficiency - BMC Bioinformatics

SPLICE-q: a Python tool for genome-wide quantification of splicing efficiency BMC Bioinformatics

Spliceator: multi-species splice site prediction using convolutional neural networks - BMC Bioinformatics

Spliceator: multi-species splice site prediction using convolutional neural networks BMC Bioinformatics

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice - Nature

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice Nature

Dylan Kissane - Labiotech.eu

Dylan Kissane Labiotech.eu

A complex epigenome-splicing crosstalk governs epithelial-to-mesenchymal transition in metastasis and brain development - Nature

A complex epigenome-splicing crosstalk governs epithelial-to-mesenchymal transition in metastasis and brain development Nature

Structural basis of a small molecule targeting RNA for a specific splicing correction - Nature

Structural basis of a small molecule targeting RNA for a specific splicing correction Nature

SpliceFinder: ab initio prediction of splice sites using convolutional neural network - BMC Bioinformatics

SpliceFinder: ab initio prediction of splice sites using convolutional neural network BMC Bioinformatics

PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity - Genome Biology

PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity Genome Biology

RNA Splicing | Learn Science at Scitable - Nature

RNA Splicing | Learn Science at Scitable Nature

101 Top Medical Startups and Companies in Spain (2021) - EU-Startups

101 Top Medical Startups and Companies in Spain (2021) EU-Startups

An improved repertoire of splicing variants and their potential roles in Arabidopsis photomorphogenic development - Genome Biology

An improved repertoire of splicing variants and their potential roles in Arabidopsis photomorphogenic development Genome Biology

SLFinder, a pipeline for the novel identification of splice-leader sequences: a good enough solution for a complex problem - BMC Bioinformatics

SLFinder, a pipeline for the novel identification of splice-leader sequences: a good enough solution for a complex problem BMC Bioinformatics

Discerning novel splice junctions derived from RNA-seq alignment: a deep learning approach - BMC Genomics

Discerning novel splice junctions derived from RNA-seq alignment: a deep learning approach BMC Genomics

Biosplice Announces Collaboration with Novo Nordisk in Diabetes - GlobeNewswire

Biosplice Announces Collaboration with Novo Nordisk in Diabetes GlobeNewswire

Splice (2009) ⭐ 5.8 | Horror, Sci-Fi - IMDb

Splice (2009) ⭐ 5.8 | Horror, Sci-Fi IMDb

Comparison of RNA-seq and microarray platforms for splice event detection using a cross-platform algorithm - BMC Genomics

Comparison of RNA-seq and microarray platforms for splice event detection using a cross-platform algorithm BMC Genomics

Genetic regulation of gene expression and splicing during a 10-year period of human aging - Genome Biology

Genetic regulation of gene expression and splicing during a 10-year period of human aging Genome Biology

Alternative splicing is required for stage differentiation in malaria parasites - Genome Biology

Alternative splicing is required for stage differentiation in malaria parasites Genome Biology

Selective degradation of splicing factor CAPERα by anticancer sulfonamides - Nature

Selective degradation of splicing factor CAPERα by anticancer sulfonamides Nature

Two splice variants of the DsMEK1 mitogen-activated protein kinase kinase (MAPKK) are involved in salt stress regulation in Dunaliella salina in different ways - Biotechnology for Biofuels and Bioproducts

Two splice variants of the DsMEK1 mitogen-activated protein kinase kinase (MAPKK) are involved in salt stress regulation in Dunaliella salina in different ways Biotechnology for Biofuels and Bioproducts

Gene-trification? Inside the Brooklyn lab where you can splice your own DNA - The Guardian

Gene-trification? Inside the Brooklyn lab where you can splice your own DNA The Guardian

Understanding alternative splicing: towards a cellular code - Nature

Understanding alternative splicing: towards a cellular code Nature

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