The Lab is headed by Prof. Alessandra Biffi, her research has always been aimed at enhancing the efficacy of HSC-based therapeutic approaches for lysosomal storage disorders with severe nervous system involvement. The activity of the group is devoted to generating novel therapeutic paradigms and clinical translation of new platforms based on the use of genetically engineered hematopoietic cells in multiple disease areas:
i) inherited neurometabolic diseases of childhood: our group is historically focused on the development of novel treatment approaches for inborn errors of metabolisms affecting lysosomal function, namely lysosomal storage disorders, based on the use of hematopoietic stem and progenitor cells and their myeloid progeny as vehicles for therapeutics in the central nervous system.
ii) autoimmune disorders: the use of autologous hematopoietic cell transplantation has been widely explored in the context of randomized multicenter clinical trials as a treatment option for autoimmune diseases, such as multiple sclerosis and type 1 diabetes.
iii) pediatric cancer, namely AML and neuroblastoma: collaborative projects have been established within our division combining the local unique expertise in pediatric oncology, advanced diagnostics and target discovery with the HC gene transfer and gene therapy expertise of the Biffi’s group.
Our group developed and optimized innovative transplant protocols to improve HSC engraftment in the brain, enhancing and accelerating microglia repopulation in recipient mice. We demonstrated that exclusive direct intra-cerebral ventricular delivery of HSCs into myeloablated mice results in efficient and rapid microglia repopulation independently from HSC engraftment in the bone marrow and hematopoietic reconstitution, increasing the specificity, efficiency, and therapeutic potential of this approach for chronic neurodegenerative diseases.
Company Details
- Founded
- -
- Address
- Corso Stati Uniti, 4f, Padua,veneto 35127,italy
- Industry
- Biotechnology Research
- NAICS
-
Research and Development in Biotechnology (except Nanobiotechnology)
- HQ
- Padua, Veneto
The Biffi Lab@unipd Questions
The Biffi Lab@Unipd's website is https://www.irpcds.org/lab/research-and-discovery-in-hematopoietic-cellgene-therapy/
The Biffi Lab@Unipd's LinkedIn profile is https://it.linkedin.com/company/the-biffi-lab-unipd
The Biffi Lab@Unipd's industry is
Biotechnology Research
The Biffi Lab@Unipd's top competitors are
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Pcr Laboratori S.r.l.,
47 Anno Domini,
Ecs S.r.l.s..
The Biffi Lab@Unipd's categories are Biotechnology Research
The Biffi Lab@Unipd's founding year is 2018
