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Innervate Therapeutics Ltd (Innervate Tx) is a biotech company focussed on targeted GDNF gene therapies to the CNS for a number of indications including Amyotrophic Lateral Sclerosis (ALS), Parkinson’s Disease (PD) and Spinal Cord Injury (SCI).
GDNF is neuroprotective and neurorestorative to motor neurons and a range of neuromodulatory neurons including dopaminergic, noradrenergic, serotoninergic and acetylcholinergic neurons. It’s potent neuroprotective and neurorestorative effects have been shown in pre-clinical models of PD, Multi System Atrophy, ALS, SCI, and epilepsy. However, because its effects are ubiquitous in the CNS it requires very precise delivery to therapeutic targets to avoid potentially harmful side effects. On the other hand, being a relatively large and sticky protein, it diffuses poorly in tissue and effective coverage of therapeutic target volumes is also challenging. Innervate Tx is positioned to maximise the neurorestorative potential of GDNF using patent protected, novel and scalable delivery methods and technology for which it has licenced exclusive use for GDNF gene therapy applications.
The company's products and technology exploit the globally recognised and pioneering clinical expertise of Prof. Steven Gill in the direct, targeted delivery of therapeutic agents to the CNS. The company has significant clinical development experience in GDNF therapy and now plans to build an equally experienced commercial management team around a newly recruited CEO.
Proof of concept studies in large animal models have been successfully completed for its ALS indication. A formal pre-clinical large animal tox study is currently underway with a phase I/II study planned for 2023. Development of a gene therapy for Parkinson’s disease is also underway with the objective of completing a phase I/II clinical study in 2024.
Company Details
- Founded
- -
- Address
- 8 Neptune Court Vanguard Way, Cardiff,wales Cf24 5pj,united Kingdom
- Industry
- Biotechnology
- Website
- http://www.innervatetx.com
- Keywords
- of Prof. Steven Gill in the direct.
- HQ
- Cardiff, Wales
Innervate Therapeutics Questions
Innervate Therapeutics's website is http://www.innervatetx.com
Innervate Therapeutics's LinkedIn profile is https://uk.linkedin.com/company/innervatetx
Innervate Therapeutics's industry is
Biotechnology
Innervate Therapeutics's top competitors are
Ivrs Ab,
Neurochase,
Rai Orchards,
Starbio International Ltd,
Human Centric Drug Discovery,
Luzsana Biotechnology Europe Ag,
Truly Translational Sweden Ab,
Uk Mnd Research Institute (Uk Mnd Ri),
The Biotech Podcast,
Excelect Ltd.
Innervate Therapeutics's categories are Biotechnology
Innervate Therapeutics's founding year is 2019
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