LAVA Therapeutics N.V.

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At LAVA, we are focused on applying our expertise in gamma-delta T-cell engagers (TCEs) to transform cancer therapy. We refer to our compounds as gamma-delta bispecific T-cell engagers, or gamma-delta bsTCEs. Our platform generates therapeutics that specifically activate a unique and relatively abundant effector gamma-delta T-cell subset called Vγ9Vδ2 (Vgamma9-Vdelta2) T-cells that have the ability to trigger activity of immune cells of both the innate and adaptive immune system. Our gamma-delta bsTCEs have demonstrated superior efficacy and safety profiles compared to other bsTCE approaches in preclinical studies and show preferential activity against tumor cells thereby potentially limiting toxicity in healthy tissue. To date, we are the only company developing bispecific gamma-delta T-cell engaging antibodies for the treatment of cancer. We are building a pipeline of gamma-delta bsTCEs that have applications in both solid and hematologic malignancies. Our lead program, LAVA-051, targets the tumor specific antigen CD1d, which can be overexpressed in multiple myeloma, chronic lymphocytic leukemia (CLL), and acute myeloid leukemia (AML), among other tumor types. LAVA-051 will enter a Phase I/IIa study in 1Q21.

Company Details

Employees
36
Founded
-
Address
Yalelaan 60, 5th Floor,united States
Phone
+31 8 506 573 44
Email
in****@****ics.com
Industry
Biotechnology Research
Website
http://www.lavatherapeutics.com/
Keywords
biotechnology, gamma delta T cells, bispecific antibodies, oncology.
HQ
Utrecht, Utrecht
Competitors
uniQure, VectorY, ProQR Therapeutics, Genmab, Leyden Labs, LUMICKS, Merus N.V., Neogene Therapeutics, Scenic Biotech, Batavia Biosciences.
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