Human Brain Disease Modelling (Lehtonen Lab)

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The Human Brain Disease Modelling research group aims to develop more physiologically relevant human-based models for studies of neurological diseases’ cellular and molecular mechanisms and the prediction of drug transport into the brain. We utilize patient-derived brain cells in 2D and 3D culture systems, including cerebral/midbrain organoids, to more accurately mimic the diseased brain’s pathological conditions. We are especially interested in the glial non-cell-autonomous mechanisms and their contribution to neurodegeneration. We use breakthrough single-cell and imaging technologies combined with bioinformatics to reveal the mechanisms and identify key therapeutic targets and pathways responsible for pathological glial phenotype.
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