Alexander Zhigalin

Alexander Zhigalin Email and Phone Number

ML Research Engineer at D. E. Shaw Research | Harvard Chem+CS A.B., Chem A.M. | IChO First Gold @ D. E. Shaw Research
new york, united states
Alexander Zhigalin's Location
United States, United States
Alexander Zhigalin's Contact Details

Alexander Zhigalin work email

Alexander Zhigalin personal email

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About Alexander Zhigalin

Alexander Zhigalin is a ML Research Engineer at D. E. Shaw Research | Harvard Chem+CS A.B., Chem A.M. | IChO First Gold at D. E. Shaw Research. He is proficient in English.

Alexander Zhigalin's Current Company Details
D. E. Shaw Research

D. E. Shaw Research

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ML Research Engineer at D. E. Shaw Research | Harvard Chem+CS A.B., Chem A.M. | IChO First Gold
new york, united states
Website:
deshawresearch.com
Employees:
133
Alexander Zhigalin Work Experience Details
  • D. E. Shaw Research
    Machine Learning Research Engineer
    D. E. Shaw Research Jan 2023 - Present
    New York, United States
    Working on deep learning models for DNA-encoded libraries (DEL), ligand-protein binding, and pocket identification.
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  • University Of Toronto
    Undergraduate Researcher, The Matter Lab
    University Of Toronto Jun 2021 - Dec 2022
    Toronto, Ontario, Canada
    Conducted a literature review on using deep generative models and reinforcement learning to generate small molecule binders based on the protein 3D information. Developed an RL-based approach to molecular design, experimentally demonstrated its validity and scalability."Scalable Fragment-Based 3D Molecular Design with Reinforcement Learning" - co-first authorship with Daniel Flam-Shepherd. Preprint: arxiv.org/abs/2202.00658.
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  • D. E. Shaw Research
    Research Intern
    D. E. Shaw Research May 2022 - Aug 2022
    New York, United States
    Constructed and optimized deep learning models for predicting the uncertainty in Free Energy Perturbations (FEP) from molecular structures to optimize the FEP simulation network building. Designed a method for breaking down the difficult morphing FEP simulations into easier ones through interpolation between small molecules using deep generative models. Experimented with various features and deep architectures (VAEs, GNNs, RNNs) to design an optimal model.
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  • Merck
    Chemistry Intern
    Merck Jun 2020 - Aug 2020
    Kenilworth, New Jersey, United States
    Participated in a novel Gram-negative antibiotic discovery and optimization project, analyzed the structure-activity relationship using medicinal chemistry software, and enumerated screening libraries. Docked virtual libraries and searched for new optimization directions. Took courses in medicinal chemistry and related topics. Attended seminars covering the drug development process and modern drug discovery approaches.
  • Harvard University
    Undergraduate Researcher, Myers Lab
    Harvard University Oct 2019 - Mar 2020
    Cambridge, Massachusetts
    Took part in making novel antibody-drug conjugates for cancer therapy. Collaborated on synthesizing the warhead (trioxacarcin and its derivatives) and various linkers.
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  • Harvard Summer School
    Teaching Fellow For Chem S-20Ab (Intensive Organic Chemistry)
    Harvard Summer School Jun 2019 - Aug 2019
    Cambridge, Ma
    Led 1-hour daily sections for 17 undergraduates, graded exams every week, and facilitated office hours. Organized a weekly optional 5-hour retrosynthesis workshop to expose interested students to more advanced synthesis problems and spark their interest in organic chemistry. Presented and explained the total synthesis of strychnine to a group of students from the workshop.
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  • Harvard University
    Undergraduate Researcher, Betley Lab
    Harvard University Jun 2019 - Aug 2019
    Cambridge, Ma
    Synthesized hexanuclear iron clusters to study their electromagnetic properties. Synthesized the most electron-deficient ligand to determine the limits of cluster formation.
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Alexander Zhigalin Education Details

Frequently Asked Questions about Alexander Zhigalin

What company does Alexander Zhigalin work for?

Alexander Zhigalin works for D. E. Shaw Research

What is Alexander Zhigalin's role at the current company?

Alexander Zhigalin's current role is ML Research Engineer at D. E. Shaw Research | Harvard Chem+CS A.B., Chem A.M. | IChO First Gold.

What is Alexander Zhigalin's email address?

Alexander Zhigalin's email address is al****@****rck.com

What schools did Alexander Zhigalin attend?

Alexander Zhigalin attended Harvard University, Harvard University.

Who are Alexander Zhigalin's colleagues?

Alexander Zhigalin's colleagues are Saksham Dalmia, Maha Rashid, Sanjeev Pandey, Vidhi Dua, Samar Bamel, Larry Nociolo, Diana Monroy.

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