Aaron Cranston Ph.D. Email and Phone Number
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Pre-clinical biologist with over 20 years' experience in oncology, spanning a strong academic career in cancer genetics followed by a productive career in drug discovery and translational science in three successful small biotechs. Most proud of olaparib which continues to make a real difference to patient treatment, survival and quality of life.Specialties: Oncology, ophthalmology, CNS, metabolism, genetics, preclinical models, project management, establishing teams, drug discovery, translational research and asset commercialisation.
Queen'S University Belfast
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Director - Translational ResearchAlmac Discovery Apr 2024 - PresentDelivered high quality preclinical candidate selection activities in a matrix team environment. Clinical positioning and biomarker development. Leading IHC activities for late-stage lead op projects and adopting machine learning and AI approaches for digital pathology and biomarker development. Evaluating new/novel approaches to improve translational predictions and clinical positioning. Site audits and establishing procedures for delivering quality systems for preclinical safety, tox and efficacy projects. Increased breadth, depth and access to preclinical partners. Established and developed good partner relations. Delivered high quality work packages to aid project positioning, inform the clinical path and achieved successful asset out-licensing.
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Head Of Translational ResearchAlmac Discovery Jul 2016 - Mar 2024Providing high quality oncology programmes in areas of unmet need. We are developing these with our partners and collaborators to deliver first-in-class and best-in-class therapies.
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Honorary LecturerQueen'S University Belfast Feb 2017 - PresentBelfast, Antrim, Gb -
Head Of In Vivo PharmacologyMission Therapeutics Jan 2014 - Jul 2016Cambridge, Cambs, GbDelivering highly innovative therapeutics targeting ubiquitin pathways to treat disease.Established MISSION's internal in vivo pharmacology capability from scratch. Delivered in vivo POC efficacy ahead of company milestones securing Series B funding.Led the internal and external preclinical pharmacology functions to progress novel agents into clinical development.Focussed on translational science activities across oncology & CNS therapeutic areas. -
Head Of In Vivo ServicesPrecos Ltd Jul 2011 - Dec 2013A client facing senior scientific project management role. Line management responsibility.Delivered preclinical models with improved predictability and improved quality to biotechs, academic institutions and major Pharma companies.Member of senior management team.
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Preclinical R&D ConsultantCambridge Preclinical Consulting Jan 2011 - Jul 2011Offering project management (APM qualified) and preclinical scientific guidance for R&D projects. -
Head - PharmacologyKudos Pharmaceuticals Ltd Sep 2006 - Aug 2010Responsible for all in-life biology and bioanalytical deliverables for multiple concurrent projects with drug discovery and translational biology aspects. Most notably, led the in vivo pharmacology development of olaparib (Lynparza), a first-in-class PARP inhibitor approved for BRCA mutant advanced ovarian cancer.Legally responsible for all in-house pre-clinical work providing in vivo data to aid selection of compounds for clinical development.Coordinated biology, DMPK, safety & PAR&D activities and influenced translational science strategy for lead DDR inhibitors (DNA-PK, ATM, ATR and mTOR) which have now entered clinical trials.Seconded to AstraZeneca PK/PD/efficacy advisory board.
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Team LeaderKudos Pharmaceuticals Ltd Jan 2003 - Sep 2006Built in-house in vivo pharmacology capability from scratch.Responsible for providing high quality data for five concurrent pre-clinical drug discovery & development projects to tight timelines.Project management of external CRO and academic collaborations.
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Team Leader, Department Of OncologyUniversity Of Cambridge May 1999 - Dec 2002Cambridge, England, GbLed MEN2 Cancer Group under auspices of Prof. Sir Bruce Ponder (Cambridge Institute for Medical Research) delivering on a CRC core funded project grant.Delivered biology projects using transgenic technologies to model human thyroid cancers in vivo; included intramural co-operation and forming a significant number of collaborations at leading international institutions.Identified and characterised new mutations; developed functional assays to advance medical genetics field and patient diagnosis/treatment; utilised network of national & international collaborations.Project management - supervised project direction & multiple lines of research. -
Postdoctoral Research FellowSidney Kimmel Cancer Center – Jefferson Health May 1996 - May 1999Philadelphia, Pennsylvania, UsNIH funded scholar exchange fellowship with Dr Richard Fishel.Biology projects modelling HNPCC using transgenic mouse models.Published extensively on mismatch repair, colon cancer and immunology.
Aaron Cranston Ph.D. Skills
Aaron Cranston Ph.D. Education Details
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Queen'S University BelfastGenetics
Frequently Asked Questions about Aaron Cranston Ph.D.
What company does Aaron Cranston Ph.D. work for?
Aaron Cranston Ph.D. works for Queen's University Belfast
What is Aaron Cranston Ph.D.'s role at the current company?
Aaron Cranston Ph.D.'s current role is Director - Translational Research, Almac Discovery Ltd. --Passionate about helping start-ups/biotechs to develop novel drugs for patients with cancer and life-threatening diseases; making a difference, changing lives..
What is Aaron Cranston Ph.D.'s email address?
Aaron Cranston Ph.D.'s email address is aa****@****net.com
What schools did Aaron Cranston Ph.D. attend?
Aaron Cranston Ph.D. attended Queen's University Belfast.
What are some of Aaron Cranston Ph.D.'s interests?
Aaron Cranston Ph.D. has interest in Science/medicine, Swimming And Charity Fundraising, Art, Gardening.
What skills is Aaron Cranston Ph.D. known for?
Aaron Cranston Ph.D. has skills like Oncology, Drug Discovery, Cancer, In Vivo, Pharmaceutical Industry, Life Sciences, Pharmacokinetics, Pharmacology, Biotechnology, Drug Development, Molecular Biology, Toxicology.
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