Aaron Mackey

Aaron Mackey Email and Phone Number

Executive Data Scientist in the Clinical Life Sciences @ Lokavant
Aaron Mackey's Location
Greater Philadelphia, United States, United States
About Aaron Mackey

Throughout my career, I've embraced diverse opportunities to develop advanced statistical models aimed at unraveling the complex biological signals concealed within extensive genomics, clinical real-world evidence (RWE), and clinical trial operations datasets. My keen interest lies in scenarios where multiple datasets can be jointly modeled, leveraging information from one another to enhance inferences across the board. Such integrated models not only enhance the signal-to-noise ratio for statistical discovery or classification but often unveil significant relationships that remain imperceptible when datasets are analyzed in isolation. Executed meticulously, this approach leads to the formulation of causal, real-world hypotheses from large, intricate datasets.I firmly believe that the outcomes derived from such analyses should be actionable, not merely informative or intriguing. They should guide the formulation of the next experiment, inform decision-making processes, or influence strategic directions. I find immense satisfaction in the prospect of utilizing data-driven insights to prompt decisions that might not have been considered otherwise. My role involves applying the principles and methodologies of decision science to assist leaders in making informed decisions based on data, despite their inherent biases, which may often be undisclosed.To better serve these objectives, I remain abreast of recent advancements in statistics, computer science, genome biology, human disease, machine learning, and data science in general. I achieve this through active participation in conferences and national and international grant review services. Engaging in collaborative efforts and consulting roles, I provide team leadership and expertise essential for bridging conceptual gaps between biologists, data scientists, computer scientists, and executive decision-makers. Over the years, I have successfully led both large and small teams, within academia and industry, in the development of custom software tools for internal use and widely utilized external customer interfaces.Despite my continued career progression within the industry, I am committed to nurturing and mentoring the next generation of computational data scientists. I fulfill this commitment within the companies and teams I collaborate with, as well as through my involvement in the CSHL Computational Genomics course and various national and international invited talks.

Aaron Mackey's Current Company Details
Lokavant

Lokavant

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Executive Data Scientist in the Clinical Life Sciences
Aaron Mackey Work Experience Details
  • Lokavant
    Svp, Ai & Data Science
    Lokavant Apr 2024 - Present
    New York, Ny, Us
  • Sonata Therapeutics
    Vp, Head Of Ai And Ml
    Sonata Therapeutics Mar 2023 - Feb 2024
    Reorganized and revamped the multifunctional data organization (data engineering, data insights, and advanced data modeling) to deliver on Sonata’s many and diverse platform biology and drug discovery program goals. Oversaw the refinement and deployment of an open-source deep learning method for oncology target profiling from human tumors, used for indication and biomarker selection in Sonata’s preclinical discovery programs. Championed and advised on the development and deployment of an LLM-based scientific Q&A chatbot, leveraging semantic literature search integrated with internal sources of text and in-house experimental platform data.
  • Roivant Sciences
    Vp Computational Multiomic Sciences
    Roivant Sciences Sep 2021 - Dec 2022
    New York, New York, Us
    Growing, mentoring, and leading a diverse multiomics team, working across multiple scientific domains, with agile insight delivery and product engineering mindset, at the intersection of discovery biology, chemoproteomics, target selection, and biomarker discovery.
  • Valo Health
    Head Of Computational Sciences
    Valo Health Mar 2019 - Jun 2021
    Lexington, Ma, Us
    In the first year of "Integral" (now out of stealth as Valo Health!), I've grown and fostered a team of 10+ outstanding data scientists, with diverse domain backgrounds in computational biology, computational chemistry, quantitative pharmacology, biostatistics, clinical informatics, and clinical epidemiology, to serve as the primary computational applications organization, responsible for delivering the value of our Opal platform to the preclinical and clinical drug discovery and development teams. Our group, in partnership with the platform development and infrastructure engineering teams, participate as peers in the concurrent development of novel algorithmic, statistical, and data pipelining methods, exploiting the latest ground-breaking methods in ML and AI, working in multi-functional matrixed teams across all business lines.
  • Covance
    Senior Director Data Sciences
    Covance Jun 2016 - Mar 2019
    Princeton, New Jersey, Us
    As an integral member of Covance's Informatics leadership team, reporting to the Chief Data Officer, I lead a small group of data scientists responsible for the "skunkwork" development of innovative new methods to capitalize on years of clinical trial data to generate actionable insights, enable predictive business intelligence, and identify new ways to help our clinical research teams execute trials more efficiently (faster and! cheaper), while also achieving higher quality for our clients, using SOTA methods in NLP, dynamic time series analysis, and quantitative risk modeling.
  • Cold Spring Harbor Laboratory
    Lecturer And Course Instructor, Computational And Comparative Genomics
    Cold Spring Harbor Laboratory Nov 2010 - Dec 2017
    Cold Spring Harbor, New York, Us
    With Drs. William Pearson, Lisa Stubbs, and James Taylor, I spend an intensive week every year delivering lectures and workshops on: review of current and historical DNA and RNA sequencing technologies; algorithms and tools for next-generation sequence analysis; variant inference and population genetics; whole genome and transcriptome assembly; differential RNA expression analysis; gene set and pathway inference; and bacterial and eukaryotic structural and functional genome annotation. I also help direct and mentor many of the student-led independent projects in these and other areas. Lecturer since 2010, Co-instructor since 2015.
  • Hemoshear Therapeutics
    Senior Director Computational Biology
    Hemoshear Therapeutics May 2012 - Jun 2016
    As the founding leader of the Computational Biology group, we have developed and built a powerful suite of bioinformatic tools for genomic data processing and visualization that provide HemoShear and external partner scientists with strong data-driven decision making abilities, including the ability to interpret coherent biological themes of mechanisms derived from integrated transcriptional and metabolic measurements.
  • University Of Virginia
    Assistant Professor, Center For Public Health Genomics
    University Of Virginia Jul 2009 - Jul 2013
    Charlottesville, Va, Us
    My research lab (2009-2013) at UVA pursued a widely diverse set of projects centered around the use of next-generation sequencing (NGS) data to: better understand human disease (genetics of type 1 diabetes and ischemic stroke, mechanisms of combinatorial drug synergy in melanoma cancers); elucidate mechanisms of plant-pathogen interactions; explore the use of cryptographically-secure algorithms for privacy-preserving exchange of genetic information; develop low-cost, pooled population resequencing algorithms for rare variant disease association studies; use RNAseq-based transcript isoform evidence to inform structural gene annotation across phylogenetic trees.
  • Baylor College Of Medicine
    Nextgen Sequencing Research Scientist
    Baylor College Of Medicine Jan 2009 - Jun 2009
    Houston, Texas, Us
    With Stephen Richards (Baylor) and Trudy Mackay (NCSU), I developed a computational genomics workflow for hybrid 454- and Illumina-based genome resequencing and annotation efforts in support of the ~200-strain DGRP (Drosophila Genetics Reference Panel).
  • Glaxosmithkline
    Investigator, Computational Biology
    Glaxosmithkline Mar 2006 - Feb 2009
    Brentford, Middlesex, Gb
  • Tacitus
    Scientific Consultant
    Tacitus Jan 2007 - Jan 2008
  • Doubleprime
    Consultant
    Doubleprime 2007 - 2008
  • Genesis Studios
    Consultant
    Genesis Studios 1999 - 2008
  • Penn Genomics Institute, Univ. Of Pennsylvania
    Apidb Project Manager
    Penn Genomics Institute, Univ. Of Pennsylvania May 2005 - Mar 2006
  • Dept. Of Biology, Univ. Of Pennsylvania
    Computational Biology Research Fellow
    Dept. Of Biology, Univ. Of Pennsylvania Mar 2004 - Apr 2005
  • University Of Virginia
    Graduate Student
    University Of Virginia Sep 1998 - Mar 2004
    Charlottesville, Va, Us

Aaron Mackey Skills

Bioinformatics Computational Biology Genomics Molecular Biology Machine Learning Sequencing Genetics R Statistics Sequence Analysis Life Sciences Perl Cancer Research Data Analysis Data Mining Lifesciences Statistical Modeling Comparative Genomics Algorithms Systems Biology Immunology High Performance Computing Databases Programming Linux Mathematical Modeling Bayesian Statistics Microarray Analysis Data Management Teaching Microbiology Database Design Bayesian Networks Graph Theory Informatics Modeling C Sql Regression Scientific Computing Latex Data Visualization Simulation Unix Mysql Software Development Pattern Recognition Functional Genomics Bioconductor

Aaron Mackey Education Details

  • University Of Virginia
    University Of Virginia
    Computational Biology
  • Washington University In St. Louis
    Washington University In St. Louis
    Immunology
  • Reed College
    Reed College
    Biochemistry And Molecular Biology
  • Breck School
    Breck School
    High School Diploma

Frequently Asked Questions about Aaron Mackey

What company does Aaron Mackey work for?

Aaron Mackey works for Lokavant

What is Aaron Mackey's role at the current company?

Aaron Mackey's current role is Executive Data Scientist in the Clinical Life Sciences.

What is Aaron Mackey's email address?

Aaron Mackey's email address is aa****@****ant.com

What is Aaron Mackey's direct phone number?

Aaron Mackey's direct phone number is +143490*****

What schools did Aaron Mackey attend?

Aaron Mackey attended University Of Virginia, Washington University In St. Louis, Reed College, Breck School.

What skills is Aaron Mackey known for?

Aaron Mackey has skills like Bioinformatics, Computational Biology, Genomics, Molecular Biology, Machine Learning, Sequencing, Genetics, R, Statistics, Sequence Analysis, Life Sciences, Perl.

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