Andrew Buckley, Phd Email and Phone Number
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A Ph.D. in Microbiology and Immunology with 13 years of research experience. Experienced in next-generation sequencing and bioinformatics, with proficiency in analyzing genomic data and advancing cell therapy programs. Possesses a unique understanding of diverse microbiomes and bacteriology, providing novel insights into disease mechanisms and cellular interactions. Skilled in stem cell induction, lentivirus creation, and tumor-homing cell therapies, aligned with cutting-edge oncology and immuno-oncology research. Expertise in R programming, dose-response modeling, and Shiny scripting, ensuring efficient data handling, predictive analytics, and result visualization. Capable of managing large-scale datasets and performing high-demand computational tasks.Areas of expertise include Multi-omics Data Analysis, Live Animal Studies, Cell Therapy, R & Python Programming, Oncology & Immunology, Machine Learning, Biostatistics, Molecular Biology, Microbiome, Dose-Response Modeling, Experimental Design & Analytics, and Biological Network Interactions— TECHNICAL SKILLS —Cell Biology: Bacterial (mostly firmicutes), fungal (yeast), and mammalian cell culture handling, growth, and fermentation in small volumes and bioreactors Molecular Biology: PCR (qPCR, Real-time), ELISA, Southern Blot, Protein expression and extraction, Protein purification, Protein characterization, Affinity Chromatography, Immunoprecipitation, Western Blot, EMSA, Flow cytometry (FACS) Live Animal Studies: Mouse, Rat, G. mellonella (waxworm) Data Analysis & Visualization: NGS Data Analysis, R programming, Python programming and scripting, Statistical Analysis, Unix Command line, QIIME, Galaxy, Bioconductor, database navigation, DESeq2, MEGA, MacVector, Data visualization and presentation (e.g., ggplot, shiny, markdown, Quarto), SQL, Microsoft Office Suite (MS Word, MS PowerPoint, MS Excel) for Mac, PC, Linux (Ubuntu/Mint),version control (git,GitHub),cytoscapeScientific Writing & Presentation: 13+ publications, grant application support, posters and presentations at ASM General Meeting, IADR, AADR regional meetings, SNO General Meeting, AGU General MeetingBiostatistics & Computational Modeling: Statistical Analysis, PCA, KNN, nnet, random forest, bootstrap, k-fold cross validation, Poisson models, dose response analysis, drc, linear regression, cytoscape networks Instruments & Analysis: Fluorescence Microscopy, bioreactors, electrophoresis, equipment maintenance
University Of North Carolina At Chapel Hill- School Of Pharmacy
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Research ScientistUniversity Of North Carolina At Chapel Hill- School Of PharmacyChapel Hill, Nc, Us
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Steering Committee MemberBio Pharma Networking Group- North Carolina Chapter Jan 2018 - PresentBio Pharma Networking in the Research Triangle of North Carolina.Registration management.Event promotion.Website Curation.Sponsor development.
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Research Scientist , BioinformaticsUniversity Of North Carolina At Chapel Hill- School Of Pharmacy Jul 2021 - Apr 2024Chapel Hill, Nc, UsConduct cutting-edge oncology investigations within a cell therapy laboratory, focusing on combating cancer by directly employing stem cells as therapeutics and navigators for CAR-T cells. Employ patient-derived cells to cultivate stem cell properties encompassing tumor-targeting and tumor-eradicating characteristics. Develop an automated process for extracting a drug sensitivity rating from an innovative cancer sensitivity diagnostic test currently awaiting patent approval. Employ patient biopsy samples cultured on tissue that mimics specific organs to evaluate drug sensitivity without relying on genetic analysis, thereby accelerating the discovery of effective treatment solutions.➢ Generated and characterized stem cell therapies➢ Utilized R programming to model dose responses for various treatments➢ Spearheaded database curation and automated analysis pipelines for novel treatments➢ Designed vectors for Lentivirus construction➢ Led primary molecular cloning and served as the go-to resource for molecular biology and bioinformatics➢ Created and curated a database for a novel lab ex vivo cancer treatment diagnostic with shiny interface for non-programmersHighlighted Accomplishments:➢ Designed multiple lentivirus vectors to improve induced neural stem cell therapies touching on cell motility, stem cell maintenance, and tumoricidal activity resulting in two published manuscripts (with three additional manuscripts currently in preparation ➢ Performed bioinformatics analysis on all the projects in the lab and proposed new cell therapy solutions from the analyzed data ➢ Enhanced designed database for diagnostic tests, streamlining data collection and analysis from 12 hours to under ten minutes while enabling seamless integration of new diagnostics into multiple machine learning models to enhance treatment selection and outcome prediction; Pending patent filing through UNC-CH School of Pharmacy
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Postdoctoral ResearcherUniversity Of North Carolina At Chapel Hill- School Of Pharmacy Jul 2019 - Jul 2021Chapel Hill, Nc, Us
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Postdoctoral Research ScientistUniversity Of North Carolina At Chapel Hill Sep 2014 - Dec 2017Chapel Hill, Nc, UsConducted pioneering research on the deep-sea floor microbiome, employing metagenomics to dissect the genetic composition of microbial communities thriving in this extreme milieu. Focused on the uncharted depths of the ocean, presenting a wealth of untapped opportunities for uncovering novel microorganisms and their bioactive compounds.➢ Managed multiple studies, including experimental design and method development of laboratory investigations and mentorship of congruent projects of undergraduate student researchers, problem-solving, and troubleshooting➢ Coordinated all laboratory environment safety reporting, maintenance, and compliance policies and procedures ➢ Oversaw data management of lab protocols documentation and raw data for inclusion in lab databasesHighlighted Accomplishments:➢ Created three novel recombinant proteins from the uncultivable deep-sea organism Beggiatoa spp. finding dual enzymatic functions for two of the recombinant proteins in similar environmental conditions➢ Identified novel networks of environmental microbes and correlated distinct chemical profiles with enzymatic function from whole genome assembly
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Doctoral CandidateUniversity Of Rochester Aug 2008 - Jun 2014Rochester, Ny, UsValidated the enzymatic function of the previously hypothetical protein pgmB in Streptococcus mutans and the effect on physiology and disease presentation. Studied the role of disparate sugar types on the carbon metabolism of S. mutans and the broader impact on the tooth polymicrobial biofilm.➢ Maintained Streptococcus mutans cultures in various conditions, including bioreactors➢ Independently investigated the enzymatic ability of the Beta-Phosphoglucomutase from S. mutans UA159 to catalyze the conversion from Beta-glucose-1-P to glucose-6-P➢ Performed physiologic characterization of gene deletion mutants of S. mutans and the effect on pathogenicity➢ Investigated the role of disaccharide-sugars on carbon metabolism networks and global gene expressionHighlighted Accomplishments:➢ Characterized a gene with unknown function pgmB from S. mutans, resulting in publication.➢ Identified three transcriptional regulators of pgmB and generated data on the effects that dietary sugars have on pgmB production -
Undergraduate ResearcherAssumption College 2004 - 2008Worcester, Massachusetts, Us➢ Characterized the Ultraviolent Light hypersensitive Halobacterium salinarium mutant. (Mentor: DJ Crowley)
Andrew Buckley, Phd Skills
Andrew Buckley, Phd Education Details
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University Of Rochester School Of Medicine And DentistryMicrobiology And Immunology -
Assumption UniversityPhysics
Frequently Asked Questions about Andrew Buckley, Phd
What company does Andrew Buckley, Phd work for?
Andrew Buckley, Phd works for University Of North Carolina At Chapel Hill- School Of Pharmacy
What is Andrew Buckley, Phd's role at the current company?
Andrew Buckley, Phd's current role is Research Scientist.
What is Andrew Buckley, Phd's email address?
Andrew Buckley, Phd's email address is an****@****unc.edu
What schools did Andrew Buckley, Phd attend?
Andrew Buckley, Phd attended University Of Rochester School Of Medicine And Dentistry, Assumption University.
What skills is Andrew Buckley, Phd known for?
Andrew Buckley, Phd has skills like Microbiology, Environmental Microbiology, Pathogenesis, Molecular Biology, Pcr, Cell Culture, Science, Microscopy, Molecular Cloning, Genetics, Cell Biology, Western Blotting.
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