Abyson Joseph, Ph.D. Email & Phone Number

Maharashtra, India

Mumbai Metropolitan Region

🔹 Responsibilities:◉ Process Development: Developing and optimizing downstream process for Biosimilars (Monoclonal Antibody based) and growth factors (Initial development, process characterization, Scale Down/ Up, Tech transfer to manufacturing) focusing on efficiency, scalability, and quality ◉ Lab Setup and Team Building: Setting up downstream process lab ensuring operational readiness and building a high-performing team of scientists and technicians.◉ Collaboration and Strategic Impact: Collaborating cross-functionally and contributing to strategic initiatives to advance product development pipelines and business objectives.

Gurugram, Haryana, India

🔹 Responsibilities and Achievements◉ Leading multiple projects in downstream process development of increasing scale and complexity, oversight of 5 junior scientists including experiment designing, planning, supervising and directing studies◉ Downstream process development: design, optimize and strategize scalable purification of therapeutic proteins from recombinant (E. coli/ Yeast/ Pichia/ Mammalian) expression systems for Pre-Clinical and Clinical studies◉ Virus-like Particles (VLPs): purification-process development and formulation (related publications https://doi.org/10.1016/j.heliyon.2021.e08124, https://www.frontiersin.org/articles/10.3389/fimmu.2023.1123805)◉ Process development, Scale-Up and Tech-transfer of a bacterial vaccine candidate; purification optimization and successful generation of DS for Tox /Pre-Clinical studies◉ Process development, Scale-Up and Tech-transfer of Biosimilars (Downstream process set from pilot 5L, 50L and scale up to 500L)◉ Charged Variant Isolation in Fabs/mAbs; Successful reduction of charged variant of a Biosimilar (proof of concept demonstrated at 500L scale)◉ Glycoconjugates: conjugation of carbohydrate moiety to carrier proteins using Lysine coupling to NHS esters◉ Delivering high quality communication (written document, telecons and face to face) to ensure outstanding customer experience. Worked with multicultural global teams (U.S, Canada, Netherlands, India)◉ Effectively and proactively collaborate with multidisciplinary scientists on an array of diverse projects to play an integral role on project and cross-functional teams. Collaborated with the analytical and upstream development teams to successfully resolve the issues faced during development.

Gurugram, Haryana, India

Thiruvananthapuram, Kerala, India

Thiruvananthapuram, Kerala, India

◉ Structural and functional characterization of transcription factors from Mycobacterium tuberculosis and Mycobacterium smegmatis◉ Biophysico-chemical characterization ◉ Structure-function relationship◉ Purification of recombinant proteins in bacterial expression system◉ Project management and Lab management

◉ As the First Graduate student of the Lab involved in establishing Research Laboratory including platforms for Molecular Biology, Protein Purification, Biochemical/Biophysical Characterization, Crystallization and X-ray Diffraction◉ Teaching and evaluation of 3 credit level course at bachelor's level for 2 semesters.◉ Assignments , doubt-solving◉ Conducting theoretical and practical exams and grading

New Delhi Area, India

◉ Rational structure based drug designing◉ Purification of Phospholipase A2 from venom ( Naja naja sagitiferra) : Affinity , Ion- exchange and Size -exclusion chromatography◉ Crystallization of purified Phospolipase A2 in complex with Non-steroidal anti-inflammatory drug (Anisic acid: 4-Methoxy Benzoic acid)

Doctor Of Philosophy (Ph.D.), Biochemistry, Biophysics And Structural Biology, Csir- Senior Research Fellow

Ph.D. thesis title: "Structural and functional characterization of Mycobacterium Gre factors and its homologs" My doctoral thesis dealt.

Master Of Technology (M.Tech), Biotechnology, A

As a part of dissertation I worked on purification and crystallization of Phospholipase A2 from Cobra venom. Aim was to form a complex.