Adam Sacks Email & Phone Number

San Antonio, Texas, United States

DNA double-strand breaks (DSBs) are involved in the pathogenesis of many cancers, and understanding DSB repair is important for developing improved cancer therapies.Currently researching the regulation of the REV7-Shieldin effector complex present in the Non-homologous end joining (NHEJ) DNA repair pathway.Investigating the role of CST protein complex, BRCA1-BARD1 ubiquitination function, and PTIP signaling protein in the regulation of DNA double-strand break repair.

San Antonio, Texas, United States

53BP1 is a key regulatory molecule in DNA double-strand break repair pathway choice, and 53BP1 function is regulated by a variety of post-translational modifications.Investigated the role of EYA4 phosphatase in the regulation of 53BP1-mediated DNA repair pathways.Utilized various methods such as in-vitro experiments, CRISPR site-directed mutagenesis, and fluorescent live cell imaging.

Austin, Texas, United States

Epigenetic modifications of RNA play an important role in the expression of genetic informationInvestigated the biochemical function of the putative RNA methyltransferase C9ORF114, which is mutated in several cancer phenotypes.Used a combination of cellular and molecular approaches, as well as next generation sequencing and mass spectrometry.

Austin, Texas, United States

Light-induced enzyme changes in plants can modulate the levels of extracellular ATP (eATP), and changes in eATP have been shown to affect plant hormonal expression.Investigated the pathways by which eATP signaling can modulate Arabidopsis root hair growthResearched the role of eATP signaling in the creation of a transgenic, salt-tolerant tomato cultivar.

Doctor Of Medicine - Md, Medicine

Doctor Of Philosophy - Phd, Integrated Biomedical Sciences

Bachelor Of Science And Arts (B.S.A), Neuroscience