Adrian Pickup Email & Phone Number

Manchester Area, United Kingdom

Cheadle, England, United Kingdom

Macclesfield, England, United Kingdom

Heald Green

Widnes

Denton

Synthesis of novel building blocks up to 600g scale. First aider/safety co-ordinator.

Alderley Park

Researched and updated the chemical risk inventory.

Singlehandedly set up the lab and made it operational. As SHE officer: implemented Health and Safety policies and received training in first aid at work.Participated in recruitment and as a team leader lead a team of chemists in designing routes and executing chemical synthesis of potential new drugs.

Chapel-en-le-Frith

Synthesis of small molecules from mg to 200g.

• Synthesis of Campaign 1 material and project intermediates.Acted as the Chemistry contact to influence synthetic chemistry route design for Oncology/ Diabetes project.Synthesis and route design of novel compounds for.
• Delivery of 350 g of final material to agreed formulated timelines using a range of reactors from 1L to 50 L.
• Altered a campaign route to avoid isolation of a problematic iodo intermediate, conditions were modified to increase the yield from 14% to 90%, published in AZ abstracts.
• Excellent collaboration with discovery chemists, worked flexibly to ensure delivery of a 20 g batch 6 weeks early for a critical tox slot. This involved good decision making as a team (democratic, fast, decisive and.
• Worked effectively with the Diabetes team giving regular progress updates, advising on best conditions for scale up and inputting options identified through the Large Scale team as alternative routes.
• Showed passion for customers by identifying final compounds and an intermediate for a Diabetes project which was then synthesised in the Large Scale lab.

• Responsibilities included:Synthesis and route design of novel compounds for biological evaluation.Safety rep for the chemistry department.Achievements included:
• Demonstrated effective reaction planning, good team working and problem solving resulting in a good number of successful syntheses.
• Rationalised formation of a novel byproduct of an oxetane rearrangement after isolation and characterisation.
• Developed an oxadiazole synthesis for a project, improving a key reaction of a guanidine formation from 40% to 90%.
• Developed a robust process enabling the rapid synthesis of 85/110 ureas after parallel chromatography and synthesis including the use of phase transfer tubes and genevac.
• Good problem solving and reaction planning in synthesising complex spiro cyclic molecules. Also contributed ideas to help solve problems for colleagues.

• Respiratory and Inflammation Lead Identification departmentCardiovascular Lead Optimisation departmentInfection Lead Optimisation departmentOncologyLead Optimisation department
• Synthesis and route design of novel compounds for biological evaluation.
• Used plate and parallel synthesis technology to generate large numbers of compounds on a small scale.

Pgce Secondary Science

Chemistry With Industrial Chemistry