Agostinho G.Rocha, Phd

Agostinho G.Rocha, Phd Email and Phone Number

Site Director @ Smithers | Drug Development, Bioanalysis @ Smithers - Pharmaceutical Development Services
Agostinho G.Rocha, Phd's Location
Trenton, New Jersey, United States, United States
Agostinho G.Rocha, Phd's Contact Details

Agostinho G.Rocha, Phd work email

Agostinho G.Rocha, Phd personal email

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About Agostinho G.Rocha, Phd

As the Site Director at Smithers PDS, a contract research organization (CRO) that offers a comprehensive range of pre-clinical and clinical drug development services, I leverage my 18+ years of experience in science to oversee the delivery of high-quality solutions to our clients.My core competencies include protein biochemistry, mechanistic enzymology, molecular biology, cell biology, drug discovery, assay development, and assay validation. I also have strong process improvement skills as well as people management skills, as I manage, coach, and mentor the operational team. I am passionate about helping people's lives by challenging the status quo and advancing the science of drug development.

Agostinho G.Rocha, Phd's Current Company Details
Smithers - Pharmaceutical Development Services

Smithers - Pharmaceutical Development Services

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Site Director @ Smithers | Drug Development, Bioanalysis
Agostinho G.Rocha, Phd Work Experience Details
  • Smithers - Pharmaceutical Development Services
    Site Director
    Smithers - Pharmaceutical Development Services Feb 2022 - Present
    Gaithersburg, Maryland, Us
    Smithers, a contract research organization (CRO), offers a comprehensive range of pre-clinical and clinical drug development services.Our expert scientists perform large molecule bioanalysis, assay development, validation, and sample analysis at our GCP, GLP and CLIA compliant laboratories.
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  • Syneos Health
    Principal Research Scientist / Group Leader
    Syneos Health Aug 2018 - Feb 2022
    Morrisville, Nc, Us
    o Managed teams of operational Scientists (Biomarkers, Critical Reagents and Cell-Based Assays)o Optimized resources and assured plans to deliver projects ahead of expected timelines and increase revenue;o Liaised with other Operational Teams to support department needs;o Aligned research projects by acting as SME;o Provided support to clients, operations and bussiness development teams;o Performed the role of Principal investigator as a bridge between the company, sponsors and regulatory agencies;o Developed, optimized and validated bioanalytical methods for quantification of protein biomarkers;o Investigated functional and biophysical characteristics of conjugated critical reagents (Rocha AG, et al. Bioanalysis);o Implemented protein biochemistry workflows;o Presented scientific findings in international conferences;o Responsible for recruitment activities, performance evaluation activities.
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  • Washington University School Of Medicine In St. Louis
    Senior Scientist
    Washington University School Of Medicine In St. Louis Jul 2018 - Aug 2018
    St. Louis, Mo, Us
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  • Washington University School Of Medicine In St. Louis
    Staff Scientist
    Washington University School Of Medicine In St. Louis Sep 2016 - Jun 2018
    St. Louis, Mo, Us
    Charcot Marie Tooth disease type 2A is a rare and debilitating neurodegenerative disease that is caused by abnormalities in mitochondrial fusion and trafficking.o Discovered first-in-class small molecules (H2L) that overcome mitochondrial defects (Rocha AG, et al. Science);o Optimized lead molecules through rational rounds of SAR;o Evaluated in vitro ADME and in vivo PK studies;o Designed cell-based functional assays for screening of small-molecule using confocal-microscopy;o Developed a FRET and a ligand-binding assay for target validation and kinetics characterization; o Rationally engineered enzymes for mechanistic studies using SDM;o Used bioinformatics to model and predict protein structure;o Prepared and implemented new SOPs; o Recruited and supervised research assistants; o Interacted and collaborated with CROs and other scientists to evolve independent projects.
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  • University Of Pennsylvania
    Postdoctoral Researcher
    University Of Pennsylvania Sep 2014 - Aug 2016
    Philadelphia, Pa, Us
    Friedreich's ataxia is a mitochondrial disorder that leads to neural and heart disease. It is caused by mutations in the FRDA gene, a key component of Fe-S cluster assembly. o Discovered a new mitochondrial kinase responsible for Fe–S metabolism (Rocha AG, et al. Mitochondrion);o Established Frataxin as a biomarker for Friedreich's ataxia using mass spectrometry;o Purified and characterized endogenous mitochondrial protein complexes from S. cerevisiae;o Engineered and purified recombinant proteins utilizing FPLC (IEX, SEC, AC and IMAC);o Characterized site-directed mutants to probe enzyme structure-function relationships; o Optimized biochemical assays for cysteine desulfurase activity;o Developed and characterized multiple yeast strains; o Wrote scientific grants and reports.
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  • Uc Davis
    Postdoctoral Researcher
    Uc Davis Sep 2012 - Aug 2014
    Davis, California, Us
    o Purified under native conditions membrane protein complexes involved in the integration of beta-barrel proteins;o Studied extensively the protein import machinery using in vitro import assays;o Established in the laboratory methods for Agrobacterium mediated transient transformation;o Generated Arabidopsis stable cell lines and performed phenotypic analysis;o Assisted and mentored undergraduate students in their research projects.
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  • Ludwig-Maximilians Universität München
    Early Stage Researcher
    Ludwig-Maximilians Universität München Sep 2008 - Aug 2012
    München, Bavaria, De
    o Discovered a new metabolic checkpoint of the Calvin-Benson and the OPP pathway (Rocha AG, et al. Biochemical J);o Identified and characterized chloroplast localized calcium-dependent phosphoproteins; o Established proteomic techniques in the laboratory (BN-PAGE, 2D-IEF-SDS, and radioisotope labeling);o Characterized phosphoproteins by mass-spectrometry;o Designed and cloned chimeric proteins used for subcellular localization studies;o Engineered, expressed in E. coli and purified recombinant proteins using automated conditions;o Optimized an assay for measuring transketolase enzyme activity;o Represented the group at EU project meetings and international conferences;o Co-organized the first international conference on Plant Organellar Signaling.
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  • University Of Vigo
    Research Assistant
    University Of Vigo 2005 - 2006
    Pontevedra, Es
    o Evaluated marine contamination using biochemical biomarkers;o Established assays for measuring catalase and glutathione S-transferase activity;o Prepared and analyzed by HPLC polycyclic aromatic hydrocarbons from contaminated water samples.
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Agostinho G.Rocha, Phd Skills

Molecular Biology Biochemistry Cell Biology Cell Culture Genetics Bioinformatics Microbiology Microscopy Drug Discovery Protein Engineering Team Leadership Multitasking Mitochondria Web Design Event Management Enzyme Kinetics Enzyme Assays Protein Purification Protein Expression Sales Management Chloroplast Akta Confocal Microscopy Conference Organization Protein Protein Interactions Protein Chromatography Fret Ligand Binding Neurodegeneration Metabolism Peptide Synthesis High Performance Liquid Chromatography Peptidomimetics Screening Drug Testing Assay Development Cell Based Assays Cell Viability Assays Protein Assays Binding Assays Image Analysis Adobe Photoshop Adobe Illustrator Dna Manipulation Rna Isolation Molecular Cloning Mass Spectrometry Phosphorylation Mouse Models Yeast Genetics

Agostinho G.Rocha, Phd Education Details

  • Ludwig-Maximilians-Universität München
    Ludwig-Maximilians-Universität München
    Biochemistry
  • Universidade Do Minho
    Universidade Do Minho
    Biology

Frequently Asked Questions about Agostinho G.Rocha, Phd

What company does Agostinho G.Rocha, Phd work for?

Agostinho G.Rocha, Phd works for Smithers - Pharmaceutical Development Services

What is Agostinho G.Rocha, Phd's role at the current company?

Agostinho G.Rocha, Phd's current role is Site Director @ Smithers | Drug Development, Bioanalysis.

What is Agostinho G.Rocha, Phd's email address?

Agostinho G.Rocha, Phd's email address is ag****@****lth.com

What schools did Agostinho G.Rocha, Phd attend?

Agostinho G.Rocha, Phd attended Ludwig-Maximilians-Universität München, Universidade Do Minho.

What skills is Agostinho G.Rocha, Phd known for?

Agostinho G.Rocha, Phd has skills like Molecular Biology, Biochemistry, Cell Biology, Cell Culture, Genetics, Bioinformatics, Microbiology, Microscopy, Drug Discovery, Protein Engineering, Team Leadership, Multitasking.

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