Andrew Woolley Email and Phone Number
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I am an expert in histology, digital pathology, and the development of novel IHC protocols and other tissue biomarker strategies for preclinical discovery and translational research. I am passionate about improving patient outcomes against disease through precision medicine. 9 years in biopharma, primarily focused on Immuno-Oncology.Expertise:- Development of novel immunohistochemistry (IHC) assays for hypothesis generation, MoA testing, IND filing, clinical study implementation, etc., utilizing extensive controls and complimentary assays (ISH, WB) for thorough assay validation- Development and implementation of multiplexed IHC assays (Opal dyes, Phenocycler, etc.)- Project management of CRO resources to transfer and deploy novel biomarkers into clinical studies- Advanced light microscopy (fluorescent slide scanners, confocal, 2-photon, etc.)- Hands-on research histology experience (Ventana, Leica, & Dako autostainers; FFPE & frozen tissue processing & sectioning; 10x spatial transcriptomics platforms; etc.)- Quantitative image analysis of digital pathology data, including cell segmentation, cell phenotyping, and spatial neighborhood analysis of whole-slide images in large cohorts (primarily in HALO by Indica Labs)- PhD in Neurobiology, focused on histological characterization of the inflammation and biological integration that occurs around chronic brain-implanted devicesI am an optimist who enjoys working with thoughtful colleagues on complex problems. ---- www.ajwoolley.com ---- personal website featuring old microscopy images
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Principal Scientist - Oncology Biomarkers Translational IhcBristol Myers Squibb Aug 2021 - PresentLawrence Township, Nj, UsResponsible for the development of well-validated tissue-based research assays and their utilization for decisional biomarker support across numerous Immuno-Oncology programs at BMS.Leading spatial-analysis characterization of histology tissues using chromogenic immunohistochemistry (IHC), multiplex immunofluorescence (mIF), in situ hybridization (ISH), spatial transcriptomics (10x platforms), and digital pathology image analysis (HALO AI platform).SME managing the transfer of novel, in-house IHC assays and materials to CRO-partners in support of multiple early-stage clinical programs.
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Senior Scientist Ii - Translational OncologyAbbvie Feb 2018 - Jul 2021North Chicago, Illinois, UsDriving the validation and execution of cutting-edge tissue-based assay technologies to inform drug discovery and translation in Oncology under the Precision Medicine organization at AbbVie.Leveraging AI-based digital pathology image analysis for cell segmentation, tissue classification, and cellular neighborhood clustering on whole-slide imaging data (IHC, ISH, IF, highplex-IF).Working closely with bioinformatics, genomics, and clinical program leads to generate predictive signatures for clinical trial biomarker decision making. -
Scientist IiSymic Bio Sep 2016 - Feb 2018San Francisco, Ca, UsResponsible for independent and team-based design, execution, and analysis of biological assays to support translation of pipeline projects and drug candidate selection with tissue-based and cell-based assays at a biopharma startup. From blood-flow assays up to preclinical animal studies, performed across a variety of indications from vascular diseases, oncology, CNS disorders & fibrosis. Work performed in-house, at microscopy facilities, and through supervising CRO partners. Responsibilities also included supporting all scientists in advanced histology, imaging, and image analysis needs, as well as managing pathology and microscopy equipment purchasing. -
Consultant Scientist (Preclinical Research)Symic Bio Jul 2015 - Aug 2016San Francisco, Ca, UsConsultant supporting preclinical, translational research at Symic Bio and other Bay Area startups, including IHC and in vitro assay development.- Optimizing experimental & histological strategies to assess novel therapeutics- Performing advance microscopy, data analysis, etc., to generate and evaluate preclinical data- Designing and supervising surgery, tissue collection, and sample processing in animal models
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Postdoctoral Research AssociateUniversity Of New South Wales Jun 2013 - May 2015Sydney, New South Wales (Nsw), AuPostdoc with Bionic Vision Australia consortium, developing visual prosthesis technology. Led imaging projects to support clinical device translation under Scientia Prof. Nigel Lovell (School of Biomedical Engineering) and Prof. John Morley (School of Medicine). http://bionicvision.org.au/- Utilizing micro-CT and 9.4T MRI equipment to image 'bionic eye' implant within tissue.- Imaging physiology (two-photon microscopy) in retinal tissue and neural cultures.- Performing translation research using human cadaver and larger lab animal tissues.- Successful grant (Cooper Medical Research Foundation): gene therapy AAV imaging in retina.- Contributing Investigator on successful grant (NHMRC): microstimulation of retinal tissue.- Conceiving, assigning, and guiding projects in the Graduate School of Biomedical Engineering. -
Postdoctoral Research AssociatePurdue University May 2011 - Jul 2012West Lafayette, In, UsDARPA-funded Postdoc in SUBNETS program. Developed and utilized advanced histological imaging and 'cranial window' imaging methods to capture device integration data within brain tissue.- Discovered depth-dependent response of immune cells to brain implanted microdevices.- Published on PNS cells entering CNS around brain implants.- Integrated 'optical clearing' strategies into the histological processing of device-implanted brain tissue, allowing deeper imaging into tissue around implanted devices.- Paired 'cranial-window' imaging with brain-implanted microelectrode arrays, imaging transgenic biomarkers over time while recording physiology and electrical impedance.- Devised and validated a 'systemic labeling' strategy to allow simultaneous assessment of blood vessel reorganization and blood-brain-barrier permeability around brain implants in histology. -
Graduate Research AssistantPurdue University Aug 2005 - Apr 2011West Lafayette, In, UsImproved our understanding of the brain-implanted microdevice integration in brain tissue. Informed the development of biomedical implants for treating diseases and disorders of the nervous system.- Developed innovative method (Device-Capture Histology) to reveal complex changes around brain implants across a variety of neural cell types (oligodendrocytes, microglia, astrocytes, neurons)- Achieved multidisciplinary expertise in aseptic surgery, laser-based microscopy, immunohistochemistry, neurobiology, immunology, and neural engineering.- Coordinated a small team to successfully integrate new research techniques into the lab.- Presented at Society for Neuroscience and other conferences (BMES, M&M, etc.).
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Graduate Teaching AssistantPurdue University Aug 2005 - Apr 2011West Lafayette, In, UsEnjoyed teaching, consistently received high teacher ratings from students:- Biology of the Living Cell- Quantitative Physiology- Advanced Genetics and Molecular Biology (Lab Instructor)- Introduction to Biological Sciences (Lab Instructor)Enjoyed mentoring students in the lab:- Assigned and managed student projects.- Trained students in lab safety and skills (surgery, microscopy, histology).- Encouraged student presentation of research, resulting in numerous poster awards.- Take pride that many of students are now professional clinicians and researchers.
Andrew Woolley Skills
Andrew Woolley Education Details
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Purdue UniversityNeurobiology -
Indiana University BloomingtonBusiness
Frequently Asked Questions about Andrew Woolley
What company does Andrew Woolley work for?
Andrew Woolley works for Bristol Myers Squibb
What is Andrew Woolley's role at the current company?
Andrew Woolley's current role is Principal Scientist | Histology & Digital Pathology.
What is Andrew Woolley's email address?
Andrew Woolley's email address is aw****@****due.edu
What schools did Andrew Woolley attend?
Andrew Woolley attended Purdue University, Indiana University Bloomington.
What skills is Andrew Woolley known for?
Andrew Woolley has skills like Microscopy, Confocal Microscopy, Biomedical Engineering, Neuroscience, Fluorescence Microscopy, Immunohistochemistry, In Vivo, Histology, Medical Devices, Science, Laboratory, Life Sciences.
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