Alan Holmes Email & Phone Number

United Kingdom

London, England, GB

London, England, GB

London, England, GB

London, Greater London, GB

London, Greater London, GB

London, Greater London, GB

The Workshop focuses on fostering an environment for interdisciplinary engagement by appealing to basic, biomedical and clinician scientists at an early stage in their careers and encouraging them to develop a long-term interest in Cardiovascular Biology and Translational Medicine.

Brussels, BE

Brentford, Middlesex, GB

Bergen, Norway, NO

London, Greater London, GB

• Established a biology drug discovery group to facilitate and support UCL discoveries and their translation into therapies leading translation programs across a broad range of disease modalities including oncology.
• Established biology resource to develop/run biochemical, cellular (including primary and phenotypic) screening for HTS, H2L and MOA.
• Drug discovery project lead for PPI, kinase, DUBs and epigenetic targets at HTS, H2L and LO.
• Established internal medium through-put biochemical screening capability.
• Supported drug discovery through externalisation to CRO and industry academic partnering.

London, Greater London, GB

• Established an internationally recognised in vivo and in vitro team to identify key signalling pathways and pathological mechanisms that contribute to pathogenic remodelling diseases including cardio vascular.
• Awarded Arthritis Research UK Fellowship.
• Developed phenotypic, multi-cellular and physiologically relevant cellular assays.
• Demonstrated mechanistic disease phenocopying between diseases with common pathobiology.
• Established the disease relevance of Endothelial Mesenchymal Transition
• Developed a broad network of academics and clinicians supporting fibrosis research www.ucl.ac.uk/flarre.

Basel, Baselstadt, CH

• Awarded the Novartis Presidential Postdoctoral Fellowship to explore the role of inflammation in pulmonary hypertension. Subsequently led an in vitro group of supporting drug discovery programs.Key achievements:
• Supported drug discovery projects across the RDA portfolio developing cellular (immortal and primary disease relevant) assays to support HTS and H2L screening.
• Conducted novel respiratory target ID and validation.
• Developed external partnerships with KOLs to support pulmonary programmed.
• Led drug discovery projects and matrix teams.
• Contributed to portfolio through proposal of novel targets and white papers.

Bethesda, MD, US

San Francisco, CA, US

Phd, Molecular Mechanisms That Contribute To Fibrosis In Scleroderma

Bsc, Biology/Biological Sciences