Albert Lee Email & Phone Number

Lead immunology/oncology projects developing drug candidates for immuno-oncology therapies.- target engagement, validation, and profiling of lead candidates. - Assay development and functional readouts using both innate and adaptive immune cells.-Principal scientist from Oct 2021 to Apr 2022

Watertown, MA, US

Serve on immunology projects developing targeted protein degradation to treat myeloid/lymphocyte-mediated diseases.- Developed cellular-based assays to evaluate the effect of the degrading disease-causing proteins in T cells using multiple autoimmune settings.-Initiated the ideation and execution of studies to evaluate the new targets for the next.

Cambridge, Massachusetts, US

Advancing discovery group projects involving Immuno-oncology/autoimmune targets - Worked on Artificial antigen presenting cells (RTX-321) projects for enhancing antigen specific T cell mediated anti-cancer activity - Performed preclinical IND-enabling studies and drafted/submitted IND studies for RTX-321 - Initiated and validated CAR-T cell projects.

Menlo Park, CA, US

Serve on immunotherapy research projects targeting human endogenous retrovirus to develop anti-tumor immunotherapy for solid tumors including breast, pancreatic, and ovarian cancers.- Identified antibodies against HERV-K generated from cancer patient samples including blood, serum and tissue. - Led in vivo prevention/vaccination studies using a mouse tumor.

San Francisco, California, US

Serve on research projects, validating the efficacy of pre-clinical trial stage therapy for treating autoimmune-induced dry eye disease, neuropathy and exocrinopathy.-Led clinical research projects focused on neuro-immunology using autoimmune murine models (AIRE KO and CD28KO mouse models). Identification of biomarkers for nerves and stem cells for the.

Boston, MA, US

• Served on research team, under the direction of Dr. Wolfgang Junger, whose lab focuses on the clinical studies of immune cells including monocytes/neutrophils/T-cells in sepsis patients.
• Characterized interactions between Toll-like receptors (TLRs) and purinergic signaling involving mitochondria that regulate NLRP3 inflammasome activation using human immune cells.
• Isolated primary immune cells to examine pharmacological assays to elucidate NLRP3 inflammasome activation involving NLRP3, ASC oligomerization, and caspase-1 activation.
• Characterized the role of mitochondria and autocrine purinergic signaling in primary human monocytes.
• Investigated Cecal Ligation and Puncture (CLP) mice to study immunological changes that occur with sepsis.

Boston, MA, US

Lab focuses on elucidating wound healing mechanisms that occur during repair of epithelium, neurons and extracellular matrix, using the cornea as a wound model. Thesis: Hypoxia induced alterations in the wound healing processes of the cornea: Ca2+ mobilization that occurs between neuronal and epithelial cells post-injury and the protein regulation involved.

Princeton, New Jersey, US

• Technical Analyst IIFunctioned as lead scientist in assisting companies to optimize protocol to meet their scientific needs according to standard operating procedures.
• Perform experimental assays to assure the quality of commercial products.
• Communicate with clients to optimize the protocol for their business.
• Comprehensive onsite service to maximize customer satisfaction.
• Performed assays including HPLC/GC to determine nutritional values in products.

Doctor Of Philosophy (Phd), Biochemistry

Bachelor Of Science (Bs), Biochemistry