Alex Bergstrom Email & Phone Number

Boulder, Colorado, United States

My current role is the biophysics lead at Pfizer Boulder, an R&D unit specializing in small molecule,precision oncology. In my role, I effectively led a team of two direct reports (one Ph.D. and one non Ph.D.), identifying critical project needs and strategically utilizing my team’s resources to address them.I’ve led a significant expansion of sitewide Biacore operations, including the acquisition of an 8K andan additional T200, to keep up with increasing demand for Biacore data. My group’s equipmentresponsibilities have included routine maintenance and managing external service for three Biacoreinstruments, two high-resolution QToFs, an ITC, and a qPCR.• Developed and deployed SPR (Biacore) assays across a variety of projects to enable hit generation(Biacore 8K HTS), lead identification (SAR support for relatively weak binders), and leadoptimization (SAR support for exceedingly potent binders)• Leveraged ITC assays both for orthogonal assay validation and in cases where SPR was not viable• Extensively utilized MS and DSF techniques to assess protein-ligand binding and ensure integrityof recombinant proteins• Developed a normal-phase LC assay capable of separating nucleotides for the purpose of 1) QCof recombinant proteins and 2) assessing nucleotides bound to the target-proteins in cell lysates• Expressed and purified challenging therapeutic targets, including rigorous QC standards to enablequality results in downstream biochemical and biophysical assays

Boulder, Co

Boulder, Co

Oxford, Oh

Dissertation Title: Spectroscopic and Mechanistic Studies of Metallo-β-Lactamase Inhibitors and theStructure-Function Relationship of New Delhi Metallo-β-Lactamase Variants As a graduate student in the Crowder lab, I performed NIH-supported research, within a large,multidisciplinary collaborative project with other universities, seeking to identify inhibitors of metalloβ-lactamases (MBLs). During my time at Miami, I mentored six undergraduate students and guidedtheir research towards publication, and in my role as the lab instrumentation specialist I trained newmembers in most lab techniques. I also gained four years of experience as a teaching assistant betweenlarge general chemistry labs and advanced undergrad physical chemistry labs.• Expressed, purified, and characterized several MBLs and other recombinant proteins• Developed methodology for characterizing MBL-inhibitor binding to assess the clinical viability ofnovel inhibitors using spectroscopy (NMR, EPR, ICP-AES, UV-vis) and mass spectrometry• Investigated structure-function relationship of over a dozen New Delhi MBL variants which showdivergence in catalytic activity and substrate preference under zinc scarcity• Initiated development of a native MS workflow capable of detecting the lifespan of MBL-inhibitor complexes and furthering our understanding of MBL inhibition mechanisms

Oxford. Oh

• Advanced Chemical Measurements Lab & General Chemistry Lab

Rock Island, Il

• Bioinformatic analysis, cloning, and expression of serine β-lactamase from thermophile, M. ruber

Doctor Of Philosophy - Phd, Biochemistry

Activities and Societies: American Chemical Society (ACS); American Society for Biochemical and Molecular Biology (ASBMB)

Bachelor'S Degree, Biochemistry

Activities and Societies: Sigma Xi - National Scientific Research Honors Society; Omicron Sigma Omicron - Social Fraternity

High School Diploma