Alex Bergstrom Email & Phone Number

Boulder, Colorado, United States

• My current role is the biophysics lead at Pfizer Boulder, an R&D unit specializing in small molecule,precision oncology. In my role, I effectively led a team of two direct reports (one Ph.D. and one non Ph.D.).
• Developed and deployed SPR (Biacore) assays across a variety of projects to enable hit generation(Biacore 8K HTS), lead identification (SAR support for relatively weak binders), and leadoptimization (SAR support for.
• Leveraged ITC assays both for orthogonal assay validation and in cases where SPR was not viable
• Extensively utilized MS and DSF techniques to assess protein-ligand binding and ensure integrityof recombinant proteins
• Developed a normal-phase LC assay capable of separating nucleotides for the purpose of 1) QCof recombinant proteins and 2) assessing nucleotides bound to the target-proteins in cell lysates
• Expressed and purified challenging therapeutic targets, including rigorous QC standards to enablequality results in downstream biochemical and biophysical assays

Boulder, CO

Boulder, CO

Oxford, OH

• Dissertation Title: Spectroscopic and Mechanistic Studies of Metallo-β-Lactamase Inhibitors and theStructure-Function Relationship of New Delhi Metallo-β-Lactamase Variants As a graduate student in the Crowder lab, I.
• Expressed, purified, and characterized several MBLs and other recombinant proteins
• Developed methodology for characterizing MBL-inhibitor binding to assess the clinical viability ofnovel inhibitors using spectroscopy (NMR, EPR, ICP-AES, UV-vis) and mass spectrometry
• Investigated structure-function relationship of over a dozen New Delhi MBL variants which showdivergence in catalytic activity and substrate preference under zinc scarcity
• Initiated development of a native MS workflow capable of detecting the lifespan of MBL-inhibitor complexes and furthering our understanding of MBL inhibition mechanisms

Oxford. OH

• Advanced Chemical Measurements Lab & General Chemistry Lab

Rock Island, IL

• Bioinformatic analysis, cloning, and expression of serine β-lactamase from thermophile, M. ruber

Doctor Of Philosophy - Phd, Biochemistry

Activities and Societies: American Chemical Society (ACS); American Society for Biochemical and Molecular Biology (ASBMB)

Bachelor'S Degree, Biochemistry

Activities and Societies: Sigma Xi - National Scientific Research Honors Society; Omicron Sigma Omicron - Social Fraternity

High School Diploma