Alexander R. French Email & Phone Number
@umass.edu
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Who is Alexander R. French? Overview
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Alexander R. French is listed as Assistant Professor at The University of Wyoming – School of Pharmacy, a with 6 employees, based in Laramie, Wyoming, United States. AeroLeads shows a work email signal at umass.edu and a matched LinkedIn profile for Alexander R. French.
Alexander R. French previously worked as Postdoctoral Researcher at School Of Molecular And Cellular Biology - University Of Illinois Urbana-Champaign and Postdoctoral Researcher, Richard van Rijn lab at Purdue University, Department Of Medicinal Chemistry And Molecular Pharmacology. Alexander R. French holds Doctor Of Philosophy (Ph.D.), Biochemistry And Molecular Biophysics from The University Of Chicago.
Email format at The University of Wyoming – School of Pharmacy
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About Alexander R. French
My core interests lie in applying protein engineering toward breaking down barriers to neuropharmacological research and development. My skill set spans the full length-scale of organismal biology from single molecule imaging to in vivo mouse behavior. Within this range I have experience in whole-cell patch clamp slice electrophysiology; mouse electroencephalography (EEG); transgenic mouse husbandry; mouse behavioral models including in vivo ethanol consumption, locomotor, and rotarod assays; extensive microscopy experience including confocal fluorescence, bioluminescence, single molecule fluorescence, and differential interference contrast (DIC); protein engineering including optogenetic, biosensor, and split enzyme complementation assay development; protein expression and purification in E. coli and SF9 cells; spectroscopy including UV/Vis and circular dichroism; assay development in the areas of animal behavior, cellular signaling and molecular function; molecular biology including gibson and quikchange cloning, DNA ligations, expression, and purification. These broad experiences make me well-suited for dynamic environments where biochemists, pharmacologists, and neuroscientists are working together. Regarding leadership, I have 10+ years of mentoring younger scientists, who have gone on to academia, medical school, and industry. I ascribe to the methods of Cohen & Cohen ("Lab Dynamics", Third Edition, 2018) wherein, within the constraints of the position, I do my best to customize and connect the work to the mentee's own motivations and career goals. I also follow their use of de-escalatory language as part of my approach pro-actively prevent and manage conflict, and use their 2:1 rule for positive feedback.
Listed skills include Protein Engineering, Single Molecule Microscopy, Protein Purification, Matlab, and 13 others.
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Alexander R. French work experience
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Assistant Professor
Assistant Professor
My lab studies how alcohol and psychedelics alter the brain in order to understand addiction and how psychedelics might be repurposed into effective treatments for alcohol misuse. We use a host of exciting techniques on a wide scale ranging from molecular to whole-animal behavior. Check us out! https://www.frenchlab.org/As an instructor, I teach Pharmacology II and co-teach Clinical Toxicology.
Postdoctoral Researcher
Objective 1: Use electrophysiology to quantify how brain-derived estrogen affects hippocampal excitability. Outcome 1: Have learned whole cell patch clamp techniques and begun collecting data in Alzheimer’s mouse model. Objective 2: Use EEG to measure cell-type specific contributions of brain estrogen to epileptogenesis. Outcome 2: Confirmed conditional knockout in TdTomato reporter mice and have nearly completed breeding program for experimental lines. Completed training on EEG and stereotactic methods to be used.
Postdoctoral Researcher, Richard Van Rijn Lab
Objective 1: Develop a novel GPCR drug screening assay for simultaneous readout of arrestin2 and arrestin3 signaling. Outcome 1: High-throughput assay reports two arrestin pathways at a GPCR in real time with 400% signal change. Objective 2: Assess the effects of biased kappa opioid receptor agonists on alcohol consumption in mice. Outcome 2: Found evidence upending previously held theory that arrestin3 signaling promotes sedation and pro-alcohol consumption behaviors at the kappa opioid receptor in a voluntary ethanol consumption model in mice.
Nih Brain F32 Postdoctoral Fellow, Richard Van Rijn Lab
Objective 1: Develop a novel GPCR drug screening assay for simultaneous readout of arrestin2 and arrestin3 signaling. Outcome 1: High-throughput assay reports two arrestin pathways at a GPCR in real time with 400% signal change. Objective 2: Assess the effects of biased kappa opioid receptor agonists on alcohol consumption in mice. Outcome 2: Found evidence upending previously held theory that arrestin3 signaling promotes sedation and pro-alcohol consumption behaviors at the kappa opioid receptor in a voluntary ethanol consumption model in mice.
Nih Brain F32 Postdoctoral Fellow, Mathew Tantama Lab
Objective: Demonstrate design of biosensors for small molecules with both fluorescent and bioluminescent outputs. Outcome: Successfully developed ATP and cAMP sensors adaptable for both in vitro plate and tissue studies
Postdoctoral Researcher, Mathew Tantama Lab
Objective: Demonstrate design of biosensors for small molecules with both fluorescent and bioluminescent outputs. Outcome: Successfully developed ATP and cAMP sensors adaptable for both in vitro plate and tissue studies.
Graduate Researcher In The Tobin Sosnick Lab, Department Of Molecular Biology And Biochemistry
Project description: Engineering the naturally light-responsive plant protein domain LOV2 to control the motor protein myosin VI using light. Since light can be focused to very small areas, doing so gives researcher high spatial and temporal control over myosin VI function. Specific experience includes:-Rational protein engineering and design-Assay development for characterization of designed proteins, including techniques such as: -Performing vivo fluorescence microscopy and in vitro single molecule TIRF microscopy -Chemical crosslinking, Interferometry, FRAP, FRET, SAXS-Protein purification from e. coli and SF9 cells-Ample molecular biology experience including plasmid and baculovirus construction
Institute For Cellular Engineering Summer Reu Progam Researcher
Project description: Use of las and lux quorum sensing systems to artificially induce programmable symbiotic relationship in Escherichia coli strains. Specific experience includes:-Designing a gene network to create artificial biological "ecosystem" using a systems biology approach.-Operating on a team to construct plasmids for study.-Characterizing gene system in strain 1 of test cultures.
Undergraduate Researcher In The Shelly Sakiyama-Elbert Lab, Department Of Biomedical Engineering
Project description: Behavioral and histological components of studies on nerve guidance conduit in rat sciatic nerve injury model. Specific experience includes:-Co-designing novel experimental apparatus and procedure.-Performing behavioral analysis of peripheral nerve injury in rat model.-Assembling pictures and quantifying nerve regeneration in fluorescent retrograde labeling studies.
Summer Laboratory Assistant
Assisted B.S.- and Ph.D.- level research staff in R&D Department with their projects. Specific experience includes:-Washing and fixing red and white blood cells.-Optimizing a wide range of products for maximum cell stability and clinical utility.-Testing products on a large array of hematology analyzers including Abbott, Coulter, and Sysmex systems.
Alexander R. French education
Doctor Of Philosophy (Ph.D.), Biochemistry And Molecular Biophysics
Bachelor Of Science (B.S.), Biomedical Engineering
Frequently asked questions about Alexander R. French
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What company does Alexander R. French work for?
Alexander R. French works for The University of Wyoming – School of Pharmacy.
What is Alexander R. French's role at The University of Wyoming – School of Pharmacy?
Alexander R. French is listed as Assistant Professor at The University of Wyoming – School of Pharmacy.
What is Alexander R. French's email address?
AeroLeads has found 1 work email signal at @umass.edu for Alexander R. French at The University of Wyoming – School of Pharmacy.
Where is Alexander R. French based?
Alexander R. French is based in Laramie, Wyoming, United States while working with The University of Wyoming – School of Pharmacy.
What companies has Alexander R. French worked for?
Alexander R. French has worked for The University Of Wyoming – School Of Pharmacy, School Of Molecular And Cellular Biology - University Of Illinois Urbana-Champaign, Purdue University, Department Of Medicinal Chemistry And Molecular Pharmacology, Purdue University, Department Of Chemistry, and The University Of Chicago.
How can I contact Alexander R. French?
You can use AeroLeads to view verified contact signals for Alexander R. French at The University of Wyoming – School of Pharmacy, including work email, phone, and LinkedIn data when available.
What schools did Alexander R. French attend?
Alexander R. French holds Doctor Of Philosophy (Ph.D.), Biochemistry And Molecular Biophysics from The University Of Chicago.
What skills is Alexander R. French known for?
Alexander R. French is listed with skills including Protein Engineering, Single Molecule Microscopy, Protein Purification, Matlab, Biomedical Engineering, Molecular Cloning, R&D, and Research.
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