Alexander R. French Email and Phone Number
Alexander R. French work email
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Alexander R. French personal email
My core interests lie in applying protein engineering toward breaking down barriers to neuropharmacological research and development. My skill set spans the full length-scale of organismal biology from single molecule imaging to in vivo mouse behavior. Within this range I have experience in whole-cell patch clamp slice electrophysiology; mouse electroencephalography (EEG); transgenic mouse husbandry; mouse behavioral models including in vivo ethanol consumption, locomotor, and rotarod assays; extensive microscopy experience including confocal fluorescence, bioluminescence, single molecule fluorescence, and differential interference contrast (DIC); protein engineering including optogenetic, biosensor, and split enzyme complementation assay development; protein expression and purification in E. coli and SF9 cells; spectroscopy including UV/Vis and circular dichroism; assay development in the areas of animal behavior, cellular signaling and molecular function; molecular biology including gibson and quikchange cloning, DNA ligations, expression, and purification. These broad experiences make me well-suited for dynamic environments where biochemists, pharmacologists, and neuroscientists are working together. Regarding leadership, I have 10+ years of mentoring younger scientists, who have gone on to academia, medical school, and industry. I ascribe to the methods of Cohen & Cohen ("Lab Dynamics", Third Edition, 2018) wherein, within the constraints of the position, I do my best to customize and connect the work to the mentee's own motivations and career goals. I also follow their use of de-escalatory language as part of my approach pro-actively prevent and manage conflict, and use their 2:1 rule for positive feedback.
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Assistant ProfessorThe University Of Wyoming – School Of PharmacyLaramie, Wy, Us -
Assistant ProfessorThe University Of Wyoming – School Of Pharmacy Aug 2024 - PresentLaramie, Wyoming, United StatesMy lab studies how alcohol and psychedelics alter the brain in order to understand addiction and how psychedelics might be repurposed into effective treatments for alcohol misuse. We use a host of exciting techniques on a wide scale ranging from molecular to whole-animal behavior. Check us out! https://www.frenchlab.org/As an instructor, I teach Pharmacology II and co-teach Clinical Toxicology. -
Postdoctoral ResearcherSchool Of Molecular And Cellular Biology - University Of Illinois Urbana-Champaign Jan 2022 - Aug 2024Champaign, Illinois, United StatesObjective 1: Use electrophysiology to quantify how brain-derived estrogen affects hippocampal excitability. Outcome 1: Have learned whole cell patch clamp techniques and begun collecting data in Alzheimer’s mouse model. Objective 2: Use EEG to measure cell-type specific contributions of brain estrogen to epileptogenesis. Outcome 2: Confirmed conditional knockout in TdTomato reporter mice and have nearly completed breeding program for experimental lines. Completed training on EEG and stereotactic methods to be used. -
Postdoctoral Researcher, Richard Van Rijn LabPurdue University, Department Of Medicinal Chemistry And Molecular Pharmacology Mar 2021 - Dec 2021Objective 1: Develop a novel GPCR drug screening assay for simultaneous readout of arrestin2 and arrestin3 signaling. Outcome 1: High-throughput assay reports two arrestin pathways at a GPCR in real time with 400% signal change. Objective 2: Assess the effects of biased kappa opioid receptor agonists on alcohol consumption in mice. Outcome 2: Found evidence upending previously held theory that arrestin3 signaling promotes sedation and pro-alcohol consumption behaviors at the kappa opioid receptor in a voluntary ethanol consumption model in mice.
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Nih Brain F32 Postdoctoral Fellow, Richard Van Rijn LabPurdue University, Department Of Medicinal Chemistry And Molecular Pharmacology Jul 2019 - Mar 2021West Lafayette, Indiana, United StatesObjective 1: Develop a novel GPCR drug screening assay for simultaneous readout of arrestin2 and arrestin3 signaling. Outcome 1: High-throughput assay reports two arrestin pathways at a GPCR in real time with 400% signal change. Objective 2: Assess the effects of biased kappa opioid receptor agonists on alcohol consumption in mice. Outcome 2: Found evidence upending previously held theory that arrestin3 signaling promotes sedation and pro-alcohol consumption behaviors at the kappa opioid receptor in a voluntary ethanol consumption model in mice.
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Nih Brain F32 Postdoctoral Fellow, Mathew Tantama LabPurdue University, Department Of Chemistry Sep 2017 - Jul 2019West Lafayette, Indiana, United StatesObjective: Demonstrate design of biosensors for small molecules with both fluorescent and bioluminescent outputs. Outcome: Successfully developed ATP and cAMP sensors adaptable for both in vitro plate and tissue studies
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Postdoctoral Researcher, Mathew Tantama LabPurdue University, Department Of Chemistry Nov 2016 - Sep 2017West Lafayette, Indiana, United StatesObjective: Demonstrate design of biosensors for small molecules with both fluorescent and bioluminescent outputs. Outcome: Successfully developed ATP and cAMP sensors adaptable for both in vitro plate and tissue studies.
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Graduate Researcher In The Tobin Sosnick Lab, Department Of Molecular Biology And BiochemistryThe University Of Chicago Aug 2011 - Oct 2016Chicago, IlProject description: Engineering the naturally light-responsive plant protein domain LOV2 to control the motor protein myosin VI using light. Since light can be focused to very small areas, doing so gives researcher high spatial and temporal control over myosin VI function. Specific experience includes:-Rational protein engineering and design-Assay development for characterization of designed proteins, including techniques such as: -Performing vivo fluorescence microscopy and in vitro single molecule TIRF microscopy -Chemical crosslinking, Interferometry, FRAP, FRET, SAXS-Protein purification from e. coli and SF9 cells-Ample molecular biology experience including plasmid and baculovirus construction -
Institute For Cellular Engineering Summer Reu Progam ResearcherUniversity Of Massachusetts Amherst Jun 2009 - Aug 2009Lianhong Sun Lab, Amherst, MaProject description: Use of las and lux quorum sensing systems to artificially induce programmable symbiotic relationship in Escherichia coli strains. Specific experience includes:-Designing a gene network to create artificial biological "ecosystem" using a systems biology approach.-Operating on a team to construct plasmids for study.-Characterizing gene system in strain 1 of test cultures. -
Undergraduate Researcher In The Shelly Sakiyama-Elbert Lab, Department Of Biomedical EngineeringWashington University In St. Louis Feb 2007 - May 2009St. Louis, MoProject description: Behavioral and histological components of studies on nerve guidance conduit in rat sciatic nerve injury model. Specific experience includes:-Co-designing novel experimental apparatus and procedure.-Performing behavioral analysis of peripheral nerve injury in rat model.-Assembling pictures and quantifying nerve regeneration in fluorescent retrograde labeling studies. -
Summer Laboratory AssistantStreck May 2008 - Aug 2008Omaha, NeAssisted B.S.- and Ph.D.- level research staff in R&D Department with their projects. Specific experience includes:-Washing and fixing red and white blood cells.-Optimizing a wide range of products for maximum cell stability and clinical utility.-Testing products on a large array of hematology analyzers including Abbott, Coulter, and Sysmex systems.
Alexander R. French Skills
Alexander R. French Education Details
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Biochemistry And Molecular Biophysics -
Biomedical Engineering
Frequently Asked Questions about Alexander R. French
What company does Alexander R. French work for?
Alexander R. French works for The University Of Wyoming – School Of Pharmacy
What is Alexander R. French's role at the current company?
Alexander R. French's current role is Assistant Professor.
What is Alexander R. French's email address?
Alexander R. French's email address is af****@****ass.edu
What schools did Alexander R. French attend?
Alexander R. French attended The University Of Chicago, Washington University In St. Louis.
What skills is Alexander R. French known for?
Alexander R. French has skills like Protein Engineering, Single Molecule Microscopy, Protein Purification, Matlab, Biomedical Engineering, Molecular Cloning, R&d, Research, Microsoft Office, Data Analysis, Molecular Biology, Microsoft Excel.
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