Identified the novel type of positive allosteric modulator for nicotinic receptor. Discovered new unorthodox acetylcholine binding site. Established cell lines that express fixed stoichiometries of acetylcholine receptors using concatemeric dimers subunits. • Tested new potential drugs using high throughput screening assays. Discovered the influence of accessory subunits and chemical chaperones on assembly of mature receptors.

Developed extensive librariy of human cell lines expressing different nicotinic receptors subunits. Designed the effective antigen and the method for large scale purification of this protein.

Using affinity and ion-exchanged chromatography purified and sequenced nicotinic receptors from chicken brains.

Discovered that glutamate receptors have different structure compared with other ligand binding receptors such as glycine or nicotinic receptors. Using site-directed mutagenesis identified glycine binding site in NMDA receptors.

Identified different isoforms of glycine receptors subunits.