Alexandre Caron Email & Phone Number

Montreal, Quebec, Ca

Waltham, Massachusetts, Us

• Led in vivo pharmacology effort on four research programs and actively contributed to the nomination of 3 development candidates (DCs) and several lead-op compounds;• Proposed in vivo pharmacology strategies at project cross-functional meetings, and elaborated experimental execution plans to drive PK, PD, and efficacy profiling of lead candidates;• Defined preclinical model portfolios in support of pursued clinical indications, including identification of translatable disease models, biomarkers, and endpoints;• Managed execution of internal and external preclinical in vivo studies;• Mentored team members in data interpretation and communication of experimental results;• Reviewed novel target opportunities;• Managed a team of 6 scientists (2 direct / 4 indirect).

Waltham, Massachusetts, Us

Waltham, Massachusetts, Us

• Acted as the pharmacology lead on three research programs by managing departmental activities, devising experimental strategies, and participating to core / senior staff meetings;• Co-led efforts to establish, characterize, and benchmark four different murine IBD models;• Demonstrated strong communication skills by presenting executive research summaries to pharma partner at Joint Steering Committee (JSC) meetings;• Showed collaborative spirit by providing study management and hands-on support to external programs, and efficiently interacting with external collaborators;• Actively participated in numerous in vivo studies, including PK, PD, and efficacy studies;• Supervised one full-time employee and two part-time employees.

Montreal, Quebec, Ca

• Characterized pharmacokinetic profile of novel drug formulations in the context of BA/BE trials (Health Canada, EMA, FDA, TGA);• Actively participated in the implementation of an IVIVC platform to predict in vivo behavior of drug formulations, and provided recommendations to R&D team;• Proposed detailed study designs based on extensive literature search (ADME profile);• Thoroughly assessed novel in-licensing opportunities / new product development;• Prepared and reviewed study documentation according to GCP / regulatory guidelines;• Ranked as “Elite” in 2013 and 2014 year-end performance evaluations.

Boston, Massachusetts, Us

• Actively participated in the identification of lead candidates by managing in vivo studies evaluating their pharmacokinetic and pharmacodynamic properties;• Recommended drug development strategies (including two major No Go decisions) to cross-functional discovery team through thorough analysis and interpretation of pre-clinical efficacy data, and conceptualization of studies with strong rationale;• Acted as the primary preclinical scientific resource for literature review, and identification of novel experimental approaches, endpoints and/or biomarkers;• Establish novel external collaborations, and supervised over 20 outsourced projects;• Prepared comprehensive scientific presentations for internal and external uses, including due diligence procedures, and Board of Directors meetings;• Closely collaborated with associate director, study director and animal healthcare supervisor to ensure lean and efficient teamworking and timely delivery on all mandates;• Ranked first amongst peers in 2011 year-end evaluation for ‘outstanding impact’.

Rahway, New Jersey, Us

• Demonstrated strong leadership aptitudes by managing research projects from study design to data analysis and interpretation;• Implemented and optimized over 20 rodent PK/PD and efficacy animal models, resulting in approval of 2 pre-clinical candidates (PCCs), and the demonstration of several in vivo proof-of-concepts (POCs);• Validated over 21 new gene candidates, having key impact on Go/No Go decisions;• Successfully led effort in transferring research projects to external sites, one of which resulted in ahead-of-schedule delivery of a novel PCC;• Established external collaborations and in/outsourcing opportunities;• Gained management skills by independently supervising COOP students;• Contributed to scientific meetings / presentations on a weekly basis;• Ranked first amongst peers in 2007 and 2009 year-end evaluations;• Recipient of 5 Awards of Excellence for outstanding contributions.

Montreal, Québec, Ca

• Actively participated in human/animal cardiopulmonary studies (6 papers published);• Characterized biodistribution and pulmonary clearance of adrenomedullin in dogs that led to the elaboration of clinical derivatives for molecular imaging of pulmonary circulation;• Developed two rat cardiovascular pathological models;• Wrote and published scientific articles and abstracts;• Elaborated detailed protocols, SOPs, scientific presentations and operating budgets;• Modeled teamwork by supervising and training five graduated students.

Montreal, Québec, Ca

M.Sc. thesis subject: GPIIb/IIIa and P-Selectin involvement in platelet activation, platelet aggregation and platelet-neutrophil interactions.Experimental Knowledge:• Cardiovascular physiopathology and pharmacology;• Pharmacology and physiology of haemostasis and blood coagulation; • Platelet and neutrophil cellular biology.

M.Sc., Cellular Biology And Pathology (Cardiovascular Pathology Option)

B.Sc., Biology (Microbiology & Immunology Option)