Alexandre Ismail, Ph.D Email & Phone Number

New York, NY, US

New York, NY, US

Paris, FR

Generative Protein Design by deep learning diffusion based methods (RFdiffusion, DiffAB, etc)Deep Learning of molecular data sets and HTS image analysis (TensorFlow, Keras, etc)Multi-Specific Antibody Design: RosettaVirtual Epitope Mapping & Alanine ScanningMolecular Dynamics (GROMACS, NAMD) on High Performance Computing (AWS)Homology Modeling (Rosetta.

Philadelphia, Pennsylvania, US

ABC transporter modeling: + Built 6 cryptic antigen homology models (WT, glycosylated, key mutant conformations, etc) + Membrane protein molecular dynamics of cryptic epitopes + Designed antigen 100 mutants + Designed antibody libraries against these antigen models with Rosetta Antibody DesignProtein Design (UniRep & RoseTTAFold)Antibody Design.

Brooklyn, New York, US

Fungal Adhesins Lab (Dr. Lipke)Using the fungal mating system for the directed evolution of SARS-CoV-2 antibodies

Brooklyn, New York, US

Protein mutant library design (with Twist Biosciences)Multiplex DNA readout designPatent review and analysisTechnology partnership evaluation

Director Director of EducationDirector of AdmissionsDirector of Student VisasDirector of Learning Resources

Paris, France, FR

Project Lead (France + Canada research project)+ Combining molecular modeling and mass spectroscopy for the structural characterization of prion-like proteins + Structural knowledge of prion-like targets will be used to rationally design or select ligands for stabilization of non-toxic conformations amenable to in vivo proteolysis.

Villejuif, FR

+ Collaborative research - Molecular modeling of amyloids with mass spectroscopy+ Teaching - Bioinformatics curriculum development - Molecular modeling course development - iGEM 2016 Advisor: Gold medal category (IONIS-Paris) - iGEM 2017 Advisor: Gold medal category (IONIS-Paris) - Rational protein modification for control by the E. coli cold shock system.

Paris, Île-de-France, FR

Molecular modeling of ubiquinone biosynthesis hydroxylasesRational identification and design of mutations to the substrate access tunnel by:+ Homology modeling+ Molecular dynamics+ Accessible volume calculation+ Small molecule docking+ Receptor based pharmacophore development for virtual screening+ Rational mutant enzyme design and testing

Molecular modeling of the chemokine signaling proteins and business development of pharmacophore screening services+ Modeled ligand-receptor interactions in the chemokine signaling network + GPCR ligand binding and activation modeling+ Designed a receptor based virtual screening library+ Proposed a new technology partnership between BioQuanta, Avatar, and.

Predicting stability and shape of novel modifications to existing therapeutic proteins, including:+ Interferon beta (for treatment of MS)+ EPO (for treatment of anemias)+ HIV Env (for vaccination against and treatment of HIV infection)

+ Migration of clinical research data from Excel to SQL+ Optical coherence tomography of the eye Anterior and posterior chambers Zeiss Visante and Stratus OCT instruments

+ Researched press coverage of Sonic Trading products and platform+ Submitted press releases to PR Newswire+ Reviewed company website logo and design

Ph.D (Université Pierre Et Marie Curie), Molecular Modeling Of Enzymes

Master'S Degree, Systems And Synthetic Biology

Master'S Degree, Biotechnology

Bachelor'S Degree, Biochemistry

Summer Science Program, Wolfram Research - Nks Summer School 2004

Bbsi Summer Program, Biomathematics, Bioinformatics, And Computational Biology

Machine Learning And Data Science

Workshop, Rosetta Workshop - Hands On Training With The Jens Meiler Lab.