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- Biotech research scientist with over 8 years of experience, including over 5 years of industry experience.- Expansive knowledge and practical experience throughout the entire preclinical drug development pipeline from candidate selection through IND-enabling studies. - Established track record of designing, executing, and analyzing in vitro and in vivo experiments. - Expertise in multiple therapeutic modalities: small molecules, ASOs, ADCs, siRNA, CRISPR, gene therapy, and cell therapy.- Skilled in developing and troubleshooting a wide range of molecular and cellular assays, including ELISA, HTRF, HiBiT, RT-qPCR, Flow Cytometry, Electrophoresis, Western Blot, and more. - Excellent communication and teamwork skills, both internally across various departments, as well as externally, working with CRO and SRA collaborators - Collaborative and enthusiastic researcher who thrives in fast-paced, dynamic companies and is proactive in seeking out ways to contribute to the team and the companyAuthor of 3 papers with 60+ citations (https://www.researchgate.net/profile/Alex-Schiffer-3)
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Scientist IHarton Therapeutics Apr 2022 - Oct 2023Cambridge, Massachusetts, United States* Employee 8 at a VC-backed startup focused on personalized immune therapies.* Cell biology team lead in charge of developing and utilizing functional assays to drive drug discovery programs forward. -
Senior Research Associate IiRemix Therapeutics Mar 2021 - Mar 2022Cambridge, Massachusetts, United States* Drove projects forward by presenting experimental results and proposing innovative next steps to cross-functional groups of 5 to 40 people.* Designed, conducted, and presented experiments, utilizing oligonucleotides, tool compounds, and expression vectors for genetic validation of 5 potential new targets.* Contributed to company growth from 7 to 40 employees by interviewing, onboarding, and training.* Managed a direct report (MS-level co-op), in addition to mentoring other bench scientists. -
Senior Research Associate IRemix Therapeutics Jan 2020 - Mar 2021Cambridge, Massachusetts, United States* Employee 7 (second bench scientist) at a VC-backed startup focused on RNA processing modulation.* Setup and validated biochemical assays for measuring mRNA and protein from various cell lines.* Developed and optimized cell-based assays and Next-Generation Sequencing (NGS) workflows.* Responsible for implementing and troubleshooting medium and high-throughput multiplex assays.
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Research Associate IiBiogen Dec 2018 - Jan 2020Cambridge, Massachusetts, United States* Developed and evaluated biochemical assays for measuring mRNA and protein from cells and tissues.* Carried out in vitro and in vivo pre-clinical pharmacology experiments for spinal muscular atrophy, focusing on RNA biology and splicing mechanisms.* Managed several simultaneous projects both internally and with SRAs and CROs.* Evaluated multiple modalities (ASO, SM, GTx) across several model systems of neuromuscular disorders. -
Research Assistant IiiBoston Children'S Hospital Oct 2017 - Dec 2018Boston, Massachusetts, United States* Investigated candidate genes involved in angiogenesis that emerged from a GWAS screen by performing genetic knockdown (morpholino ASO) and genetic rescue (mRNA expression vectors) studies.* Characterized targets by creating zebrafish and mouse knockout lines through CRISPR/Cas9 gene editing.* Evaluated small molecules and peptide therapeutics through microscopy-based in vivo zebrafish assays.* Optimized genotyping pipelines, including microsatellite analysis and next-generation sequencing (NGS). -
Research Assistant IiBoston Children'S Hospital Oct 2016 - Oct 2017Boston, Massachusetts, United States* Analyzed protein expression via western blots, in situ hybridization (ISH), and ELISA.* Maintained and passaged tumor cell lines and performed tumor experiments in mice.* Automated laborious data analysis by developing FIJI algorithms in Python for zebrafish vasculature.
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Intern - Molecular Biology And Genetic EngineeringNortheastern University Aug 2016 - Oct 2016Greater Boston Area• Screened C. elegans for potential mutants using PCR and digestion based genotyping.• Injected C. elegans using CRISPR/Cas9 to create specific mutations through HDR.• Sub-cloned, cultured, isolated, and verified plasmid clones through round-the-horn (RTH) PCR and Gibson assembly.• Cut down on genotyping time by over 6 hours by implementing and optimizing tetra-primer ARMS PCR genotyping assay.• Assisted in general lab maintenance: poured and seeded plates, prepared stock solutions. -
Undergraduate Research AssistantUniversity Of Central Florida Jan 2013 - May 2015Orlando, FlKey member of a small research team focused on the biogeography and biodistribution of aquatic microorganisms. Responsible for data wrangling, cleaning, and analysis.• Participated in the design of novel experiments, formulation of hypotheses, and construction of tests for analysis.• Manipulated, compiled, organized, and analyzed large data sets using Microsoft EXCEL and R.• Wrote R code scripts for geospatial analysis of water chemistry and zooplankton biodiversity in lakes across the United States.
Alex Schiffer Skills
Alex Schiffer Education Details
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3.9 Gpa -
3.6 Overall Gpa
Frequently Asked Questions about Alex Schiffer
What is Alex Schiffer's role at the current company?
Alex Schiffer's current role is Biotech Scientist Specializing in Molecular and Cellular Biology for Drug Discovery.
What is Alex Schiffer's email address?
Alex Schiffer's email address is al****@****ucf.edu
What schools did Alex Schiffer attend?
Alex Schiffer attended Boston University, University Of Central Florida.
What skills is Alex Schiffer known for?
Alex Schiffer has skills like Research, Technical Writing, Molecular Biology, Experimental Design, Data Analysis, Biochemistry, Biotechnology, Microsoft Word, Biology, Confocal Microscopy, Fluorescence Microscopy, Html5.
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Alex Schiffer
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