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• Thoughtful, creative immunologist/cell biologist with 12 years of experience investigating cytotoxic T cell function through advanced microscopy techniques. • My research applies quantitative imaging approaches to visualize and measure effects of perturbation on biological systems with a special focus on live cell imaging of cytotoxic T lymphocyte (CTL) killing of cancer cells. • Extensive experience in data acquisition and analysis with a broad range of cutting-edge imaging modalities including live cell imaging techniques (Lattice light sheet, spinning disc microscopy, TIRF imaging, live cell super-resolution, and widefield fluorescence) and fixed standard- and super-resolution microscopy (SIM, PALM). I know what imaging techniques are appropriate to answer specific biological questions. • Developed quantitative approach to measure instantaneous killing of targets by T cells in real time following therapeutic intervention or genetic perturbation in both 2D and 3D tumor cultures. • Identified novel mechanism by which cancer cells resist killing by cytotoxic T cells. • Established quantitative imaging techniques to monitor subcellular dynamics of organelles and cytoskeleton in CTLs destroying cancer cells.• Captured and produced quality images and videos that are widely used to demonstrate cytotoxic T cell activity in scientific talks, textbooks, online, and on television. • Maintain connections with a wide network of microscopy experts at top academic institutions to share knowledge and collaborate. • Glass worker with 4 years of experience. Recent projects include modeling biological systems with hot glass.
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Senior ScientistAltos Labs Sep 2022 - Present -
Postdoctoral Researcher In The Laboratory Of Ira Mellman- Department Of Cancer ImmunologyGenentech Feb 2016 - Sep 2022South San Francisco, California, UsI Investigate the mechanism of action of inhibitory "checkpoint" receptors on the surface of cytolytic immune cells. I am interested developing a better understanding of the biology behind these important, clinically relevant molecules. I'm also interested in finding new targets for therapeutic intervention in the context of cancer. -
Graduate FellowNational Institutes Of Health Aug 2009 - Jan 2016Bethesda, Md, UsStudied the involvement of the cytoskeleton in the regulation of lytic granule secretion in cytotoxic T lymphocytes (CTLs). Applied and adapted a variety of advanced live cell and super-resolution microscopy techniques including Lattice Light sheet microscopy, structured illumination microscopy, dynamic stochastic optical reconstruction microscopy (dSTORM ), and spinning disc confocal microscopy to dissect sub-cellular structure of CTLs as they interact with and destroy cancer cells.
Alex Ritter Skills
Alex Ritter Education Details
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University Of CambridgeCell Biology And Immunology -
Concordia CollegeBiology And Chemistry -
Williston High School
Frequently Asked Questions about Alex Ritter
What company does Alex Ritter work for?
Alex Ritter works for Altos Labs
What is Alex Ritter's role at the current company?
Alex Ritter's current role is Altos Labs Senior Scientist.
What is Alex Ritter's email address?
Alex Ritter's email address is al****@****ail.com
What is Alex Ritter's direct phone number?
Alex Ritter's direct phone number is +170157*****
What schools did Alex Ritter attend?
Alex Ritter attended University Of Cambridge, Concordia College, Williston High School.
What are some of Alex Ritter's interests?
Alex Ritter has interest in Science And Technology, Education.
What skills is Alex Ritter known for?
Alex Ritter has skills like Molecular Biology, Cell Culture, Research, Data Analysis, Immunofluorescence, T Cells, Cell Biology, Live Cell Imaging, Cell, Biochemistry, Pcr, Science.
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