A Delaware-based privately-owned biotechnology company that is focused on creating a greener and more sustainable world by unlocking the full potential of microbes.

A Delaware-based privately owned biopharmaceutical company dedicated to delivering affordable cancer specialty medicines to approximately 2 billion people in 85 countries classified as Low to Middle Income Countries (LMIC) by the World Bank, and with a corporate social responsibility (CSR) to reinvest locally to promote medical, science and technology education.

If you are ever seeking business advise you can request a meeting with me through my profile on AdvisoryCloud at https://www.advisorycloud.com/profile/Alexzander-Asea

Disease progression and drug response vary significantly from patient to patient. Precision medicine, also called personalized medicine, is an approach to patient care that allows doctors to select specific treatments that are most likely to help specific patients based on a proteogenomic understanding of their disease. The concept of proteogenomics harnesses and integrates mass spectrometry-derived proteomic data with genomic and transcriptomic data for the identification of biomarkers and therapeutic targets; a critical goal of precision medicine.

My responsibilities include:• Undertaking a wide range of laboratory-based activities to help diagnose, monitor and treat patients with a range of oncological disorders. • Liaising with clinical and laboratory staff, such as radiation oncologists, biomedical scientists, nurse specialists and postdoctoral scholars to discuss research designs. • Design Phase 0-2 clinical trials. • Mentoring medical students, nursing students, graduate students, postdoctoral scholars, junior faculty and other hospital staff.• Perform independent translational research in the role of heat shock proteins in biology and medicine.

My responsibilities include:• Liaising with clinical and laboratory staff, such as radiation oncologists, biomedical scientists, nurse specialists and postdoctoral scholars to discuss research designs. • Design Phase 0-2 clinical trials. • Mentoring, teaching, training and mentoring medical students, nursing students, graduate students, postdoctoral scholars, junior faculty and other hospital staff.

My responsibilities included:• Providing leadership and vision in shaping the universities strategic research directions and agenda.• Setting standards and expectations for research success at the university, measure outcomes and provide conditions for continuous improvement.• Developing a higher profile for the full spectrum of research and scholarly activities in all academic units of the University while building on existing areas of research strength and scholarly activity.• Providing services to new and established faculty, including research funding application assistance, research ethics, post-award financial administration, facilitation of contact with industry and government, and other research support services.• Matching the universities strengths and strategic directions with partnership and funding opportunities in external environment. Proactively pursue new partnerships and funding sources such as granting councils, foundations, contracts and collaborative relationships, for the full range of our academic programs and research activities.• Extending the scope and stature of the office through building linkages with the alumnae councils and their members, the offices of Development and Marketing and Communications, and through mentoring and support programs for faculty and researchers.• Addressing issues of ethics in research and intellectual property rights.• Maintaining strong communications and information flows between the Office of the President and academic units.• Developing and strengthens relations with government and elected officials to help shape public policy and programs affecting research.• Perform independent translational research in the role of heat shock proteins in biology and medicine.

My responsibilities include:• Mentoring graduate students, postdoctoral scholars, junior faculty and other hospital staff.• Perform independent translational research in the role of heat shock proteins in neurological diseases and disorders.

• Provided leadership in the development and implementation of strategies to promote excellence in research, work with academic units and partners to direct the development of a trans-college, transcampus integrated department.• Increased the Departments research stature and funding.• Developed the infrastructure needed to establish robust, high quality, well-funded and compliant research programs and provide coordination of faculty in submitting interdisciplinary/ translational research proposals.• Worked closely with the hiring units in the recruitment and selection of key faculty and research positions, and provide input to promotion and tenure decisions regarding those faculty.• Worked closely with the Office for Advancement to play a central role in the coordination and implementation of strategies relevant to major gifts and donor engagement to support growth of the Department.• Worked closely with the Vice President for Research to support effective regulatory compliance, resource allocation, technology transfer and other issues relevant to the Department. • Served on the Research Council, as requested, to provide assistance on assessment of policy, resource and procedural improvements.• Served as the public liaison to internal and external constituents, supported the development of outreach activities.• Supported strategic expansion of the Department’s research campus wide.• Perform independent translational research in the role of heat shock proteins in biology and medicine.

My responsibilities included:• Providing leadership of the Proteomics Core Facility services for the analysis of proteins from tissues, cells or other biological samples. • Provided initial experimental design through to publication. • Offered an array of sample preparation and instrumentation services, as well as method development and in-depth consultation to help researchers optimize their experimental design. • Offered several services including: protein identification, protein characterization, phosphoproteomics, large-scale proteomic profiling, and protein-protein interaction analyses. • Offered comprehensive data analysis through a variety of database search engines (Mascot, Sequest) and software packages including Protein Pilot, Proteome Discoverer, and MaxQuant. • Performed bioinformatics analysis using Ingenuity Pathway Analysis (IPA), David, and Perseus. • Organized workshops and graduate courses for students, faculty and researchers in the field of proteomics.

My responsibilities included:• Leadership, administration and academic development of the division. • Ensured the proper teaching of the programs of study, and prepare the teaching schedule in consultation with voting faculty members.• Appointed academic advisors to students majoring in the division.• Prepared budget proposals of the department in consultation with the Department Chairman.• Prepared course or clerkship description and related material for the university catalogue.• Presented to the Department Chairman, in accordance with established university procedures, recommendations on all matters pertaining to appointment, reappointment or non-reappointment, promotion, appointment to indeterminate status, periodic paid research leave, leave of absence, and advancement in remuneration of academic personnel.• Co-ordinated and approved expenditures within the budget of the division. • Prepared the annual and research reports of the division for transmission to the Department Chairman.• Appointed ad hoc committees as was deemed necessary.• Recommended to the Department Chairman the appointment of an acting Chairperson or Director during my absence.• Purchased equipment (minor and major) needed by the division.• Approved faculty and staff leaves (annual, home, conferences, sick, sabbatical).• Perform independent translational research in the role of heat shock proteins in biology and medicine.

My responsibilities included:• Developed operating plan and strategic objectives that support the center's research and development strategies. • In collaboration with the Chief, determined overall organizational structure and allocations of managerial responsibilities. • Provided leadership to direct others in solving complex problems. • Reviewed and approved all major projects. • Exercised authority to implement and initiate projects. • Participated with the Chief and senior management in developing and establishing organizational and divisional policies. • Developed new technology enhancement into the research area. • Responsible for the scientific and career growth of employees.• Perform independent translational research in the role of heat shock proteins in biology and medicine.

Promoted to Instructor in Radiation Oncology and began working on projects that revealed a novel role of heat shock proteins as both chaperones and cytokines - chaperokines. References:1. Asea, A., Kabingu, E., Stevenson, M. A., Calderwood, S. K. HSP70 peptide-bearing and peptide-negative preparations act as chaperokines. Cell Stress Chaperones. 2000 Nov;5(5):425-31. PubMed PMID: 11189447. Pubmed Central PMCID: 312872. 2. Asea, A., Kraeft, S. K., Kurt-Jones, E. A., Stevenson, M. A., Chen, L. B., Finberg, R. W., Koo, G. C., Calderwood, S. K. HSP70 stimulates cytokine production through a CD14-dependent pathway, demonstrating its dual role as a chaperone and cytokine. Nature Medicine 2000 Apr;6(4):435-42. PubMed PMID: 10742151. 10.1038/74697.3. Asea, A., Ara, G., Teicher, B. A., Stevenson, M. A., Calderwood, S. K. Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo. Int J Hyperthermia. 2001 Jul-Aug;17(4):347-56. PubMed PMID: 11471985. 4. Asea, A., Mallick, R., Lechpammer, S., Ara, G., Teicher, B. A., Fiorentino, S., Stevenson, M. A., Calderwood, S. K. Cyclooxygenase inhibitors are potent sensitizers of prostate tumours to hyperthermia and radiation. Int J Hyperthermia. 2001 Sep-Oct;17(5):401-14. PubMed PMID: 11587078.

Recruited to determine the signal transduction pathway mediated by heat shock factor-1 (HSF-1) in response to pro-inflammatory cytokine responses.References:1. Stevenson, M. A., Zhao, M. J., Asea, A., Coleman, C. N., Calderwood, S. K. Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes. J Immunol. 1999 Nov 15;163(10):5608-16. PubMed PMID: 10553090. 2. Xie, Y., Cahill, C. M., Asea, A., Auron, P. E., Calderwood, S. K. Heat shock proteins and regulation of cytokine expression. Infect Dis Obstet Gynecol. 1999;7(1-2):26-30. PubMed PMID: 10231005. Pubmed Central PMCID: 1784720. 10.1155/S106474499900006X.3. He, H., Chen, C., Xie, Y., Asea, A., Calderwood, S. K. HSP70 and heat shock factor 1 cooperate to repress Ras-induced transcriptional activation of the c-fos gene. Cell Stress Chaperones. 2000 Nov;5(5):406-11. PubMed PMID: 11189444. Pubmed Central PMCID: 312869. 4. Hecker, K. H., Asea, A., Kobayashi, K., Green, S., Tang, D., Calderwood, S. K. Mutation detection in the human HSP7OB' gene by denaturing high-performance liquid chromatography. Cell Stress Chaperones. 2000 Nov;5(5):415-24. PubMed PMID: 11189446. Pubmed Central PMCID: 312871. 5. Soncin, F., Asea, A., Zhang, X., Stevenson, M. A., Calderwood, S. K. Role of calcium activated kinases and phosphatases in heat shock factor-1 activation. Int J Mol Med. 2000 Dec;6(6):705-10. PubMed PMID: 11078832. 6. Wang, X., Asea, A., Xie, Y., Kabingu, E., Stevenson, M. A., Calderwood, S. K. RSK2 represses HSF1 activation during heat shock. Cell Stress Chaperones. 2000 Nov;5(5):432-7. PubMed PMID: 11189448. Pubmed Central PMCID: 312873.

Recruited to further our understanding of NK T cells during anti-inflammatory responses as seen during allergic reactions or asthma. Our studies demonstrated that NK T cells are regulated via NK1.1+ cell surface receptors. References:Stein-Streilein, J., Asea, A., Montalvo, J., Maniaci, V., Wanner, A. Role of NK1.1+ cells in immune regulation. Periodicum Biologrum 1997;23:34-39.

Recruited to further our understanding of NK T cells during anti-inflammatory responses as seen during allergic reactions or asthma. Our studies demonstrated that NK T cells are regulated via NK1.1+ cell surface receptors. References:Stein-Streilein, J., Asea, A., Montalvo, J., Maniaci, V., Wanner, A. Role of NK1.1+ cells in immune regulation. Periodicum Biologrum 1997;23:34-39.

Recruited to work on a project designed to elucidate the role of natural killer (NK) cells in patients with pulmonary fibrosis. My studies discovered a unique role for NK T cells in the regulation of immune responses.References:Asea, A., Stein-Streilein, J. Signalling through NK1.1 triggers NK cells to die but induces NK T cells to produce interleukin-4. Immunology. 1998 Feb;93(2):296-305. PubMed PMID: 9616382. Pubmed Central PMCID: 1364192.