Alicia Koblansky Email & Phone Number

Durham, North Carolina, United States

Research Triangle Park, Nc

Chapel Hill, North Carolina, United States

Research Triangle Park, Nc

Women In Bio-Research Triangle Park (RTP) chapter is a dynamic organization committed to developing and promoting leadership and entrepreneurship by women in one of the largest high-tech research and development centers in North America. The club's goal is to develop a community of professionals that provides mentorship and stimulates opportunities for women at all stages of their career-from those just starting out to well-established, industry veterans. Through our chapter, women can connect… Show more Women In Bio-Research Triangle Park (RTP) chapter is a dynamic organization committed to developing and promoting leadership and entrepreneurship by women in one of the largest high-tech research and development centers in North America. The club's goal is to develop a community of professionals that provides mentorship and stimulates opportunities for women at all stages of their career-from those just starting out to well-established, industry veterans. Through our chapter, women can connect and network with peers and mentors, providing opportunities for them to maximize their career potential. Show less

Chapel Hill, Nc

• Characterized role of NOD-like receptors (NLR), in CD4+ and CD8+ T-cell activation, maturation, and exhaustion. • Experienced in designing and evaluating Immunoassays. • Identified innate sensors and validated their roles in viral immunology, chronic inflammation and infectious diseases, gastrointestinal inflammation, colitis-associated colon cancer, and their interactions with the microbiome.• Developed complex cellular systems and animal models that mimic aspects of human… Show more • Characterized role of NOD-like receptors (NLR), in CD4+ and CD8+ T-cell activation, maturation, and exhaustion. • Experienced in designing and evaluating Immunoassays. • Identified innate sensors and validated their roles in viral immunology, chronic inflammation and infectious diseases, gastrointestinal inflammation, colitis-associated colon cancer, and their interactions with the microbiome.• Developed complex cellular systems and animal models that mimic aspects of human disease and uncovering novel biology relevant to human immune-mediated diseases particularly IBD, inflammatory driven cancers, and infectious diseases. • Used intestinal stem cell and organoid cell culture for analysis of tissue homeostasis in chronic inflammation driven colorectal cancers and analysis of the microbiome.• Extensive work analyzing the molecular and cellular mechanisms of innate and adaptive responses to the microbiome in cancer and colitis. • Prepared two independent grant proposals that resulted in external funding within the first three months of postdoctoral training: Research supplement to promote diversity in Health-Related Research (PA-12-149) and T32 Postdoctoral Fellow, Lineberger Comprehensive Cancer Center.• Supervised three Laboratory Technicians to conduct experiments for multi-departmental project grants.• Technical Skills: Immunological techniques with tissue and cell culture, cell isolation, purification and activation of primary mouse immune cells, like T-cell, B-cell, NK cells, macrophage, dendritic cells, flow cytometry, ELISAs, cell based assay systems, cellular proliferation assays, cellular functional assays, RT-PCR, immunocytochemistry, signal transduction pathways analysis by Western Blot with relevance to T-cell activation, autoimmune diseases and inflammation, cancer, innate immunity, and infectious diseases Show less

University Of North Carolina At Chapel Hill

• Served on a multidisciplinary team to assess applications of technology for commercialization. The role included evaluating the intellectual property (IP) landscape, exploring market opportunities, conducting market research, and creating a product development path.• Facilitated meetings between inventors and industry prospects to set a path towards commercialization.• Designed content, structure, and provided a presentation for the commercialization report that served as a… Show more • Served on a multidisciplinary team to assess applications of technology for commercialization. The role included evaluating the intellectual property (IP) landscape, exploring market opportunities, conducting market research, and creating a product development path.• Facilitated meetings between inventors and industry prospects to set a path towards commercialization.• Designed content, structure, and provided a presentation for the commercialization report that served as a foundation for a business plan. Show less

New Haven, Ct

• Characterized role of novel Toll-Like Receptors (TLR) in conventional dendritic cells, plasmacytoid dendritic cells, Natural Killer cells and macrophage in response to infections from Toxoplasma gondii, Salmonella spp., Burcella, and mouse models of Malaria. • Immunocytochemistry and analysis of signal transduction pathways with relevance to dendritic cell, macrophage, and plasmacytoid dendritic cell function.• Experience in cloning and generating new TLR constructs for in vitro… Show more • Characterized role of novel Toll-Like Receptors (TLR) in conventional dendritic cells, plasmacytoid dendritic cells, Natural Killer cells and macrophage in response to infections from Toxoplasma gondii, Salmonella spp., Burcella, and mouse models of Malaria. • Immunocytochemistry and analysis of signal transduction pathways with relevance to dendritic cell, macrophage, and plasmacytoid dendritic cell function.• Experience in cloning and generating new TLR constructs for in vitro analysis.• Recipient of Homeland Security Fellowship which included an internship at Lawrence Livermore National Laboratories studying Yersinia pestis infections by proteomic analysis.• Managed mouse colony either, Germ-Free and Specific Pathogen Free, which included extensive handling of mice, obtaining blood and tissue samples ordering, breeding, and genotyping. • Expertise in writing and editing animal protocols for IACUC.• Co-authored a highly cited review on Toll-Like Receptors and their respective signaling pathways (over 400 citations).• Mentored and advised two undergraduate students whose work was published in peer-reviewed journals and went on to receive their Ph.D.’s at Harvard and Columbia University, respectively. • Technical Skills: Extensive work in immunological, biochemical and molecular biology techniques like RT-PCR, cloning, restriction mapping, FACS, Western blot analysis, tissue and cell culture, cell isolation, purification and activation of primary mouse immune cells including optimization of ELISAs for analysis of Interferon alpha. Show less

Alameda, Ca

• Developed GMP manufacturing processes for gene therapy products.• Participated in the formulation of recombinant Adeno-Associated Virus (AAV) therapeutic drug for Clinical Phase I/II trials for Hemophilia therapy.• Experience in analysis of viral vectors for identity, purity, aggregation and stability. • Hands-on experience with AKTA (Explorer, Avant, Pure) chromatography and filtration (TFF, NFF) systems for large scale plasmid DNA and virus purification for… Show more • Developed GMP manufacturing processes for gene therapy products.• Participated in the formulation of recombinant Adeno-Associated Virus (AAV) therapeutic drug for Clinical Phase I/II trials for Hemophilia therapy.• Experience in analysis of viral vectors for identity, purity, aggregation and stability. • Hands-on experience with AKTA (Explorer, Avant, Pure) chromatography and filtration (TFF, NFF) systems for large scale plasmid DNA and virus purification for therapy.• Proficient in authoring and reviewing standard operating procedures, technical reports, documentation, and patent applications. Show less

Alameda, Ca

• Executed mammalian and insect cell culture experiments with the goal of developing scalable productive processes for viral vectors with appropriate product quality attributes for clinical applications under GMP and pre-GMP procedures. • Experience in cell based analytical assay development and validation for cell therapy manufacturing processes intended to support GMP manufacturing.• Experience in transfection and transduction of mammalian cells for recombinant AAV… Show more • Executed mammalian and insect cell culture experiments with the goal of developing scalable productive processes for viral vectors with appropriate product quality attributes for clinical applications under GMP and pre-GMP procedures. • Experience in cell based analytical assay development and validation for cell therapy manufacturing processes intended to support GMP manufacturing.• Experience in transfection and transduction of mammalian cells for recombinant AAV vectors.• Supervised team of five to complete project goals on schedule.• Experience with writing, reviewing, and proper implementation of standard operating procedures, cGMP and GLP requirements with applicable Regulatory documents and batch production records. Show less

Doctor Of Philosophy (Ph.D.), Pharmacology

B.S., Biology