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Characterizes dose-response drug induced organ injury to identify clinical risks. Experience in systemic, ophthalmic, local delivery, and dermal drug development of small molecules and proteins in diverse therapeutic areas: pain, metabolic diseases, wound healing, transplantation, anti-fungal, oncology, and BPH. Published ex vivo translational models: liver, kidney, lung, intestine, skin, thyroid, heart, and front of the eye.
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Sr Scientific Director Investigative SciencesAllergan Inc 2003 - 2013Irvine, CaStrategic leader to gain insight on human drug response to side-effects, efficacy, or biomarkers. Leader of Focus Groups and contributed to improving communication about compounds on elevation track for nomination to development. ➢ Systemic pain projects: valvulopathy, hemolysis, liver oxidative stress, thyroid retention ➢ Local delivery projects: neurotoxin mechanism of action on prostate and bladder➢ Ophthalmic projects: eye drops and implants on issues of heart injury, cornea oxidative stress, healing rates following wound repair, and biomarkers of retinal injury and innate immune response -
Associate Director Experimental Toxicology & PathologyNovartis 1997 - 2003E Hanover, NjLed investigational studies to address questions about species differences and human response. Established human ex vivo models, gene and protein expression and metabonomic technologies.➢ Supported the therapeutic areas of metabolic diseases and oncology➢ Contributed to development of a diclofenac successor, cyclosporin successors, and statins -
Lab Head In Vitro Drug Metabolism And Investigative ToxicologySandoz Pharma Ag 1986 - 1997Basel, SwitzerlandSupported ADME package leading induction/inhibition studies, organ specific biotransformation studies, and drug-drug interaction studies. Addressed species differences in mechanisms of toxicity using in vitro methods. ➢ Contributed to the development of Lamisil, Exelon, Zelnorm, tropisetron, CSA analogues, rapamycin and ASM.
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Nih/Niehs Postdoctoral FellowNrsa 1983 - 1986Research Triangle Park, NcDemonstrated that the synthetic estrogen, ethinylestradiol, mediated tumor promotion via receptor pathways involved in growth control, estrogen receptor, EGF receptor, and cell ploidy.
Alison Vickers, Phd Skills
Alison Vickers, Phd Education Details
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Phd Pharmacology And Toxicology -
Ba Pharmacology
Frequently Asked Questions about Alison Vickers, Phd
What is Alison Vickers, Phd's role at the current company?
Alison Vickers, Phd's current role is Expertise in Translational Drug Safety.
What is Alison Vickers, Phd's email address?
Alison Vickers, Phd's email address is al****@****gan.com
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What schools did Alison Vickers, Phd attend?
Alison Vickers, Phd attended University Of Arizona, University Of California, Santa Barbara.
What skills is Alison Vickers, Phd known for?
Alison Vickers, Phd has skills like Translational Research, Biomarkers, Drug Discovery, Drug Safety, Drug Metabolism, Pharmacology, Drug Development, Adme, Pharmacokinetics, Toxicology, Glp, Clinical Development.
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