-Using a yeast model system, we investigate and reengineer AAA+ proteins, primarily Heat Shock Protein 104, capable of solubilizing misfolded protein aggregates implicated in neurodegenerative disorders-Biology and biochemistry

-Tutor students in biology, with a focus on Genetics

-Using fluorescence and UV-visible spectroscopy, we studied the oligomerization of GQ stabilizing porphyrin N-methyl mesoporphyrin IX (NMM).-Using x-ray crystallography and circular dichroism spectroscopy, we investigated the specific structural conformation of oncogene promoter region sequences c-Myc and Ac-Kit1 G-quadruplexes both alone and in complex with G-quadruplex (GQ) binding ligands. We also determined the degree of stabilization fluorescent porphyrins provide c-Myc and Ac-Kit1… Show more -Using fluorescence and UV-visible spectroscopy, we studied the oligomerization of GQ stabilizing porphyrin N-methyl mesoporphyrin IX (NMM).-Using x-ray crystallography and circular dichroism spectroscopy, we investigated the specific structural conformation of oncogene promoter region sequences c-Myc and Ac-Kit1 G-quadruplexes both alone and in complex with G-quadruplex (GQ) binding ligands. We also determined the degree of stabilization fluorescent porphyrins provide c-Myc and Ac-Kit1 G-quadruplexes.-Structural biochemistry and inorganic chemistry Show less

-Studied the distribution dynamics and functional importance of NHERF1 in the regulation of MRP-2 trafficking in hepatocytes.-Biology and biochemistry