Alyson Smith's Location
Bothell, Washington, United States, United States
Alyson Smith's Contact Details
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About Alyson Smith
Passionate about changing lives through innovative discovery science. I am currently a Director at Pfizer, a focused on 'outdoing cancer' and revolutionizing cancer care. I have extensive experience across disciplines leading teams doing innovative research in a various industry settings. Focused in immunology, vaccinology and oncology drug discovery and development. All opinions expressed are my own.
Alyson Smith's Current Company Details
Alyson Smith Work Experience Details
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Callio Therapeutics
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Director Of Adc ImmunologyPfizer Dec 2023 - PresentNew York, New York, Us -
DirectorSeagen Apr 2022 - Dec 2023Bothell, Washington, Us -
Associate Director, ImmunologySeagen Jun 2021 - Apr 2022Bothell, Washington, Us
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Principal Scientist, ImmunologySeagen May 2018 - Jun 2021Bothell, Washington, Us
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Director Of ImmunologyInimmune Jul 2016 - May 2018Missoula, Montana, UsManaged immunology laboratory personnel (4 Sr. scientists) developing and testing multiple classes of novel innate immune modulating compounds. Managed work for a variety of external contract agencies while interfacing with external collaborators. Collaborated with leaders and cross-functional teams (synthetic chemistry, process chemistry and formulations) to develop and execute experimental plans to advance drug candidates to pre-IND. Oversaw design and development of novel business ideas for next generation immunomodulatory agents.o Helped orchestrate multiple collaborative research agreements and collaborations with several large pharma and biotech partnerso Managed several large, multi-team projects with external pharmaceutical company collaborators with on-time delivery of all milestones o Oversaw internal pre-clinical development of a novel set of innate immunodulating compounds resulting in patent filing -
Assistant Research ProfessorUniversity Of Montana Jan 2016 - May 2018Missoula, Mt, UsDesigned experimental plans and managed laboratory scientists preforming in vitro and in vivo experiments to investigate new small molecule innate immune receptor agonists, including several TLR (7/8 and 4) and C-type lectin receptors, for development of novel adjuvants for use in next generation vaccines, as cancer immunotherapies and treatments for autoimmune disorders. o Work resulted in two first-author publications, several other co-author manuscriptso Listed as key investigator or PI/Co-PI on 3 grantso Listed as inventor on 3 patents -
Postdoctoral ScientistGlaxosmithkline Jun 2012 - Dec 2015Brentford, Middlesex, GbDesign and direct industrial research projects focused on developing and screening novel pathogen-recognition receptor agonist compounds as vaccine adjuvants for oncology and infectious diseases. Specifically, induction of CD4+ and CD8+ T cell responses induced by dendritic cell/APC activation by various antigen/adjuvant combinations. In depth knowledge of both the innate and adaptive immune response. • Lead and supervise immunology cell-based assay development team; both in-house team and external, academic collaborators o Generated many different engineered reporter cell lines for compound screening o Screened several different small-molecule immunomodulator compounds in various in vitro, cell-based assays (HEK reporter, ELISA/Luminex, FACS, DC:T cell co-culture)• Devised and generated initial data with a multi-disciplinary team (chemist and formulations scientist) to propose an innovative business idea to top management – novel cancer vaccine strategy; currently being patented • Co-wrote and edited the technical proposal for the now fully funded, multi-institutional, NIH adjuvant development grant BAA-NIAID-DAIT-NIHAI2013168 – $13.4 million/5 years • Technical and regulatory document writing and editing; presentation of data and research plans to internal and external entities on regular (monthly) basis -
Postdocotral Research FellowMayo Clinic Mar 2011 - Jun 2012Rochester, Minnesota, UsConceived and led a multi-disciplinary research team to utilize patient-specific induced pluripotent stem (iPS) cells to regenerate hypertrophied ventricles in pediatric patients with a congenital heart disease called hypoplastic left heart syndrome (HLHS). Specifically, I developed and optimized a novel method to exploit the hypersensitivity of pluripotent stem cells to DNA damage-induced apoptosis to purge a therapeutic population of semi-differentiated cardiopoetic stem cells of the risk of tumor growth and augment the safety profile of these transplant-ready, bioengineered cells. • Named inventor on patent, filed December 2014• Authored a grant that secured $50K in funding for maximizing the cardiac reparative capacity of therapeutic stem cells by pharmacologically purging teratoma-forming cells • Mentored several summer and graduate students. • Learned and applied project management principles, and project management software, to enhance deliverables in basic research -
Predoctoral StudentMayo Clinic Jul 2006 - Feb 2011Rochester, Minnesota, UsDesigned and executed research on discovery of novel post translational mechanisms of regulation of pro-apoptotic BH3-only proteins and determining how those mechanisms regulate induction of apoptosis in response to various small molecule antineoplastic agents in several cancer malignancies. Also analyzed effect of lymphoma-associated mutations in the anti-apoptotic protein Bcl-2 on response to certain small-molecule oncology drugs. • Experience using various molecular biology/biochemistry and human cellular biology techniques (siRNA, cloning/transgene expression, antibody production, flow cytometry, westerns, qPCR, etc.) to delineate pathways involved in oncogenic signaling and apoptosis • Studied lymphoid malignancies mechanism(s) of resistance to an anti-cancer agent• Trainee recipient of Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training grant (T32)
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Research AideUniversity Of Wyoming Aug 2002 - May 2006Laramie, Wy, UsGenetic engineering, expression and mechanical testing of synthetic spider silk protein, transgenically produced in alfalfa and Arabidopsis. Analysis of the conserved N-terminal domains in major ampullate spidroin protein. • Recipient of National Science Foundation EPSCoR Undergraduate Research Fellowship, 3x
Alyson Smith Skills
Flow Cytometry
Cell Culture
Cell Biology
Protein Chemistry
Molecular Biology
Stem Cells
Cell
Vaccines
Transfection
Immunofluorescence
Rt Pcr
Protein Expression
Protein Purification
Immunology
Western Blotting
Molecular Cloning
Immunohistochemistry
Confocal Microscopy
Qpcr
Immunoprecipitation
Elisa
Tissue Culture
Pharmacology
Cancer Research
Animal Models
Genetics
Proteomics
Rna Isolation
Stem Cell Biology
Alyson Smith Education Details
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Mayo Clinic Graduate School Of Biomedical SciencesMolecular Pharmacology And Experimental Therapeutics -
University Of WyomingMolecular Biology And Chemistry
Frequently Asked Questions about Alyson Smith
What company does Alyson Smith work for?
Alyson Smith works for Callio Therapeutics
What is Alyson Smith's role at the current company?
Alyson Smith's current role is Director at Pfizer.
What is Alyson Smith's email address?
Alyson Smith's email address is sm****@****ayo.edu
What is Alyson Smith's direct phone number?
Alyson Smith's direct phone number is +130776*****
What schools did Alyson Smith attend?
Alyson Smith attended Mayo Clinic Graduate School Of Biomedical Sciences, University Of Wyoming.
What skills is Alyson Smith known for?
Alyson Smith has skills like Flow Cytometry, Cell Culture, Cell Biology, Protein Chemistry, Molecular Biology, Stem Cells, Cell, Vaccines, Transfection, Immunofluorescence, Rt Pcr, Protein Expression.
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