Amanda E. Brinker Email & Phone Number

Shawnee, Ks, Us

My role within The Institute for Advancing Medical Innovation (IAMI) is to direct product development focused translational research within the University of Kansas Cancer Center, The University of Kansas, as well as with our external for-profit and not-for-profit partners. We recruit multi-disciplinary teams of bench scientists, clinical researchers, and statisticians to advance promising therapeutics from early concept to clinical trials, ie: bench-to-bedside. My responsibilities include managing multiple project-based research teams which are cancer or rare disease focused, as well as serving on steering committees to evaluate Investigator Initiated Trial concepts and early proof-of-concept bench projects. In addition to evaluating the scientific merits of existing proposals, I generate new project ideas from new literature or bedside observations. Furthermore, I am engaged with our entrepreneurs-in-residence, venture capital partners, and intellectual property attorneys to write investment memos which detail and evaluate the future financial and business implications of projects. Additionally, I organize and write academic grants, government small business grants, progress reports, and scientific manuscripts as well as representing our group through webinars, patient-outreach events, and scientific conferences.

Kansas City, Kansas

Kansas City, Kansas

Saint Louis

Cell-Based Assays Groupo Utilized molecular biology techniques to knock out specific genes in target cell lines using Zinc Finger Nucleaseso Evaluated new technologies to update and streamline clone screening practiceso Developed a project for and mentored an undergraduate summer interno Automated plate based functional assays to evaluate current cell lineso Oversaw the installation and maintenance of equipment in new lab spaceso Designed and inserted donor fragments into Lenti Virus for external partnerso Member of the Laclede Safety Committee responsible for maintaining and promoting a safe work environment through monthly inspections and building wide initiatives

Indications Discovery CoEo Promoted August 2009o Applied molecular biology techniques to execute disease relevant functional assays.o Employed multiplexed ELISA technology to accelerate biomarker analysis.o Assisted in implementation of novel inventory approach to ensure quality control of materials with internal and external partners.o Created and implemented new documentation to significantly reduce time from collaboration inception to compound shipment for external partners.o Participated in Biologics Sub-Committee to gather, inventory, and maintain biologics for testing.o Member of steering group for large scale assay panel, functioning to increase efficiencies by organizing efforts, improving data handling and critically reviewing panel for further strategic uses.o Facilitated transition to new compound ordering system.o Involved in the implementation of new electronic notebook system. Served as an expert point of contact within the department and collaborated with external experts on development of notebook tools to suit end user needs.o Part of a team that overhauled the global protocol system and subsequently helped train colleagues to use the new system.o Member of the Safety Committee responsible for insuring a safe work environment through quarterly inspections, site-wide initiatives, and ongoing process improvements. o Participated in Move Committee. Coordinated large scale move of shared equipment and worked with external vendors to maintain integrity of high performance machines.o Aided in planning of laboratory space in a new research building including major equipment placement and insuring space design met the needs of multiple diverse teams.

Cardiovascular Biochemical Pharmacology Groupo Performed and analyzed automated directed screens to identify small molecule effectors of molecular targets driving key project decisions.o Researched, formulated, developed, and validated new Terbium FRET technology for use in in-vitro assays: Used for detection of multiple cytokines, Transferred technology for detection of eicosanoids, Validated use for detection of large proteinso Provided support to team by performing routine mammalian cell culture work and RNA isolation.o Responsible for maintaining all protocols and data in company wide database.o Member of a super-user group identified to pilot and train colleagues on new data analysis software.o Member of the Assay Center Team responsible for maintaining and troubleshooting equipment in an automation intensive lab: Liquid Handlers – Biomek NX and Biomek FX, Multidrops, Microdrops, and Hummingbirds; Plate Washers; Tecan Genesis Automated Workstation; Plate Readers – Tecan Safire2, Tecan Ultra, Perkin Elmer EnVision, Perkin Elmer TopCount

Doctor Of Philosophy (Phd), Molecular And Integrative Physiology And Cancer Biology

Activities and Societies: American Association of Cancer Researchers, American Society for Cell Biology, Physiology Society Graduate.

Bs, Biology

Activities and Societies: Alpha Sigma Alpha, Order of Omega B.S. Biology – Cum Laude o Under Graduate Research - Worked with Dr. Steven.