Amanda Ng Email & Phone Number

Vienna

• Led the development of the method “isogenic Cell Painting Assay” for discovering a class of drugs called molecular glues that enables the discovery of molecular glues targeting a wider range of proteins than previously.
• Built a HPC-compatible data pipeline using cellpose (pre-trained computer vision segmentation algorithm), Python and Julia data science libraries and CellProfiler (Python-based image analysis software) for image.
• Developed a feature selection and analysis approach for comparing cell morphology across different cell lines employing various statistical tests (e.g. Kendall’s tau-b correlation coefficient, Pearson’s correlation).
• Carried out network analysis to investigate the underlying bioactivities of hit compounds from the isogenic Cell Painting Assay, resulting in the discovery of a novel molecular glue.

Singapore

• Carried out an RNAi screen in Caenorhabditis elegans, which identified a suppressor of PAR-1 involved in early organism development
• Observed the effect of the supressor using spinning disc confocal microscopy
• Analysed images in ImageJ using a customised macro and Python script

Edmonton, Alberta, Canada

• Synthesised non-infectious prion mimics of deer chronic wasting disease (CWD) prions for use in raising antibodies against CWD prions

Singapore

• Synthesised boronic esters, carbamates and oxa-aza-borolans for the development of a novel peptide synthesis method

Singapore

• Assisted in sequencing patient samples and categorising heterozygosity status of EGFR SNP

Doctorate Degree, Malignant Diseases

Bachelor'S Degree, Science

Activities and Societies: University Scholars Programme & Special Programme in Science

High School, Science

Activities and Societies: Environmental Science Society