Amaël Madec Email & Phone Number

Boston, MA, US

Cambridge, Massachusetts, United States

Cambridge, Massachusetts, United States

Cambridge, Massachusetts, United States

Transitioned from chemistry to project lead on a fast pace LO project. Managing a team of 4 internal chemists as well as 15 to 18 FTEs at CRO. - Lead chemistry on the project from early LO to DC-Defined target profile and optimized compounds to fit the aforementioned profile. - Paused the lead series and transitioned to a less mature series showing bettr.

Cambridge, Massachusetts, United States

- Worked on projects from hit to lead to LO on oncology targets, by designing, synthesizing and prioritizing synthesis of small molecules focused on optimizing potency and DMPK properties in order to answer in-vivo POC.- Managed large team of CRO partners in Asia. - Established collaboration with local CRO. - Worked on cross-functional teams, keeping a.

Cambridge, Massachusetts

• Worked on a lead optimization series of a relevant oncology target. Modified existing synthetic routes to allow for late stage diversification thus leading to a higher turnover of analogs. Used automated screening.
• Designed and synthesized compounds with improved potency and overall DMPK (stability, permeability/efflux). Selected new candidates for in-vivo ¬PK and efficacy studies.
• Worked hands in hands with computational chemistry teams for the design of new analogs. Developed a new workflow between synthetic and computational chemists, in order to streamline the design/docking of new analogs in.
• Managed CROs collaboration as FFS or FTE.
• Developed strong cross functional relationship with multidisciplinary drug-discovery team internally at the BroadInstitute and with partners at Bayer. Involved in the generation of new biochemical assay and in the.

Cambridge, Massachusetts, United States

Cambridge, Massachusetts

• Led project team to develop low nanomolar inhibitors against PglD, an acetyltransferase enzyme of Campylobacter Jejuni using fragment based approach and optimized via protein X-ray crystallography and in silico docking
• Ability to lead a multidisciplinary team in order to develop a library of uridine based inhibitors using a novel solid phase synthesis approach
• Designed and synthesized conjugation strategy to increase bioavailability of bacterial inhibitors, including the synthesis of biologically active synthetic siderophores
• Design and synthesized solvatochromic dyes for fragment screening
• Expressed and purified proteins for biochemical testing of novel inhibitors
• Mentored undergraduates and master’s research projects

Cambridge, Massachusetts, United States

Postdoctoral Associate

Nottingham, United Kingdom

• Development of an enantioselective copper catalyzed 1,6- borylation, applied to the total synthesis of Atorvastatin
• Development of an enantioselective synthesis of complex bicyclic compounds by chiral phosphoric acid-catalyzed 1,4 addition
• Mentored a master’s research project, leading to successful completion of a master’s thesis
• Taught undergraduate tutorials and laboratory classes

Development of small molecule inhibitors against N-glycosylation pathway in gram negative organism.

Doctor Of Philosophy (Ph.D.), Organic Chemistry, Pr Hon Wai Lam Group

Activities and Societies: 2nd and 3rd years of PhD

Doctor Of Philosophy (Ph.D.), Organic Chemistry, Pr Hon Wai Lam Group

First year of PhD

Master'S Degree, Chemistry