Allison Mcnamara M.Sc. Email and Phone Number

Role 1 Worked closely with Directors and Leaders of the Cancer Care Alberta, Cancer Research & Analytics Portfolio by assisting with strategic research planning and business reporting to highlight program success and key research metrics. Responsibilities include:- Developed communication tools to present scientific and analytical research done by Cancer Research & Analytics. - Completed environmental scans of research done by other cancer centres to better understand the landscape of cancer research in Canada. -Review of published studies by Cancer Research & Analytics to create lay summaries of research and communicate research findings to a broader audience.Role 2Conduct Real World Late Phase studies in oncology as per International Conference on Harmonization - Good Clinical Practice (ICH-GCP) Guidelines within the Clinical Outcome Research Group. Responsibilities include:Knowledge of local requirements for real world late phase studies. High quality data capture (chart abstraction activities and data collection)Correspondence with Sponsors, Medical Monitors and Clinical Research Organizations. Start-up activities, screening, consenting, enrolling, monitoring visits, and sponsor queries. Prepare ethics amendments for existing studies, and correspondence with ethics and sponsors. Maintenance and organization of all regulatory and study documentation to FDA / Health Canada standards.Liaison between patients, care staff, physicians, sponsors, and laboratories to ensure understanding and adherence to protocols and GCP.

The Cross Cancer Institute is the comprehensive cancer centre with a large catchment area and a strong Clinical Trial Unit. Working with the Clinical Trial Launch Team, I analyze and review financial contracts and budgets from external pharmaceutical companies to support the launch and entire lifecycle of a clinical trial at the Cross Cancer Institute.My work involves the following: -Analysis and review of Phase I, II and III clinical trial protocols and associated medical manuals including a wide variety of solid tumor groups and hematological malignancies to draft and develop site-level internal financial budgets and documents. -Review and edit site-drafted budgets to ensure all laboratory tests diagnostic imaging, procedures, pharmacy workload, startup, closeout and study staff personnel fees are appropriately budgeted while maintaining a contingency fund. -Build and maintain strong relationships and collaborations with internal Clinical Trial Nurses and Coordinators, Laboratory and Pharmacy staff to confirm standard of care procedures, tests and financial details of planned site clinical trial activities. -Collaboration with Financial Analysts and Grant Administrators to ensure Cross Cancer Institute Site budgets were comprehensive, covered site fees and were appropriately amended when required. -Negotiated complex financial documents with external Pharmaceutical Sponsors and Clinical Research Organizations to reach a financial agreement to incorporate in the site contract Clinical Trial Master Agreement. -Mentoring and training of new clinical trial budget staff including Budget Coordinators and the Senior Financial Analyst.

Studied the interactions between colorectal cancer, extracellular vesicles (exosomes) and the immune system to undercover new and novel mechanisms by which immune cells get stimulated to mediate anti-tumor immunity against colorectal cancer.- Isolation and analysis of exosomes by micro-flow cytometry-In vitro primary cell assays to investigate the role of exosomes in dendritic cell, macrophage and T cell biology by flow cytometry-Mouse colorectal cancer tumor models to investigate the role of exosomes and anti-tumor immune responseSkills include:-Critical review of scientific data and literature for informed decision-making and planning of experiments-Design, execution, troubleshooting of complex cancer science research projects-Analysis of complex data sets with ability to summarize, comprehend and present results to specialist and non-specialist audiences-Established peer-to-peer relationships through mentorship of other students and involvement on student committees

Research in immunology investigating the role of novel genes in T cell biology. Laboratory work involved the use of in vitro primary cell assays, in vivo mouse models and the use of fluorescent antibody multicolour flow cytometry to investigate T cell phenotypes.

Research in immunology investigating the role of various survival factors in T cell biology. Laboratory work involved the use of in vitro primary cell assays and the use of fluorescent antibody multicolour flow cytometry to investigate T cell phenotypes.