Anthony Melvin Crasto Africure Row2Tech Ipca Diponed Niper-G Email & Phone Number

Thane, Mh, In

Mumbai, Maharashtra, In

Bengaluru, Karnataka, In

Ebene, Mauritius, Mu

To create value addition to brand AFRICURE, Recommend technical talent, Identify joint ventures between Global companies/Indian and Africure to do business in Africa. Assist in locating tech and identifying to provide tech transfer. Refer Africure to relevant global companies and Indian programmes and get better visibility. Paticipate in aquisitions, mergers, tieup and identify them.

Parsippany, New Jersey, Us

WEBSITE https://mkplgroup.com/

Bandra East, Mumbai , Maharashtra, In

MEDICINAL CHEMISTRY, SCALEUP OF API AND INT

Saikheda, Madhya Pradesh, In

Jaipur, Rajasthan, In

Noida, Uttar Pradesh, In

Academic Industry interaction Medchem, Drug Discovery

Designated by Dr Huz Khorakiwala at a function in Mumbai India. view YouTube video of title

100 lakh views, 227 countries, 7 continentsMentor, Advisor, Medchem, Greenchem, Drugs, Business devl, API, Process Research, Regulatory, IPR, QA, Drug Disc, Green chem, 10000 steps handled 32 years process research, 200 API targets, 30 plus products commercialization in full career, troubleshooting, cost reduction, shortest route, Scale-up, QBD, DOE, Polymorphism, literature, NIP Routes, IP, all softwares etc

7 th July 2017 Received Best Worlddrugtracker Title for lifetime acheivement in Pharma... The venue Taj land ends, Bandra, Mumbai 🇮🇳 India

Mumbai, In

Mentor, Advisor, Medchem, Greenchem, Drugs, Business devl, API, Process Research, Regulatory, IPR, QA, Drug Disc, Green chem, Scale-up, QBD, DOE, Polymorphism, literature, cost reduction, NIP Routes, IP, etc

Mumbai, In

Process research

Pali, Rajasthan, In

Mumbai, Maharashtra, In

Mumbai, Maharashtra, In

Worked with GLENMARK GENERICS LTD research centre as Principal Scientist, process research (bulk actives) at Mahape ,Navi Mumbai,and leading a team of scientists in developing APIs for regulated markets, this involves visualization and execution of novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis in lab and commercialization on plant , support for DMF filing.Currently, involved in development of several targets for regulated markets. Provide support to US/European marketing team for developing and execution of new projectsProcess Development :-• Providing guidance and support for process development for challenging of patents in regulated market.• Design patent non-infringing scalable synthetic routes/process and scale-up of API’s• Bench and Pilot scale synthesis transformations in hands on• Optimization of the process, ie,developing industrially feasible process.• Preparation of PDR, filing of patent and DMF• Lead a group of Scientists and Group Leaders(for docs). Skill sets:- Technical skills:Synthesis:• Development of novel synthetic routes/process for pharmaceuticals and successful implementation of the technology in pilot plant• Conducted various reactions at laboratory and production scales. • Synthesized various classes of compounds. • Experienced to work under cGMP conditionDocumentation: • Literature survey: well conversant with the use of Sci Finder and Internet search techniques.• Operating Instruction: Preparation of scale up report (process, yield, costing, quality, specification etc.).• Setting of specifications: Supported analytical section for method development and establishment of specification for Raw Material, Intermediate and finished products. Soft skills:-• Creativity in problem solving, Highly motivated and Self-starting individual, Excellent communication skill,Team leader with good listening

Mumbai, Maharashtra, In

joined Glenmark with allround experience described in this profile

Mumbai, Maharashtra, In

RESEARCH ACTIVITIES COVERED IN THE ENTIRE CAREER1) Extensive range of chemistry and scale of manufacture from laboratory, scale up laboratory, pilot plant, plant scale including third party activity.Applied intellectual and synthetic skills to the process development of pharmaceutical drugs/their intermediates, and natural products, neutraceuticals, mettalocenes, speciality chemicals, flavours and fragrances in the laboratory and monitor them during plant trials.Act as a technology transfer man and provide all data required for transfer from lab to commercialization.Use of Internet and manual literature search methods to decide on non infringing routeWrite DHR for API before implementation of novel route in the plant and assist for all batches for the DMF purposes, very well versed with IPR issues Ability to develop novel routes for API,s and draft patents,well versed with polymorphism issues.several patents filed in US/EUtotal exp23+ in industry, Currently working as principal scientist and leading a team of scientists in developing APIs for regulated markets, this involves novel routes, polymorphs, and developing intellectual property to protect the invention. This involves all aspects of synthesis and commercialization and assist in providing support for DMF filing.Currently involved in development of several targets for regulated markets. The job involves visualization of novel routes and its execution , simultaneously develop intellectual property and generate data in the process,. Provide support to US/European marketing team for developing and execution of new projects

Led a team of 30 chemists for the custom synthesis business in the area of drugs, organic intermediates, speciality chemicals, flavours and fragrances, nutraceuticals and mettalocenes. (25 projects) This included rapid development, scale up and commercialization as per the needs of the foreign clients with a time frame.customers were Sandoz Basel, BASF Germany, Note.....In custom synthesis most of the time the customer chases the chemist then the higherups who are unable to motivate the scientists use this as shoulder for their gun to fire.......all shit

Mumbai, Maharashtra, In

1 Donepezil : Manufactured 4 kilos on pilot plant scale as R & D demonstration, the process was developed from scratch. Plans are to make 25 kilos with 300% profit margins2) Pantoprazole : Process is being modified continuously to cope-up with price crash3) PZL Chloride an intermediate of Pantoprazole : Multi step process is being continuously modified / developed to meet cost demands4) Manufactured 3 tonnes deltamethrin on plant scale as R & D demonstration at an commercially viable cost, the process was developed from scratch ie lit,lab work, scale-up, pilot trials and also included third party work for one bromination step,which needed 8 reactors. Later on annually about 25 tonnes were manufactured. later on the company was taken over by a multinational for deltamethrin. the price in market crashed to half.5) Acetamiprid : Developed a process from scratch. Process was handed over to isagro for commercialization in 2001 during hiving of the company from RPG6) M-alcohol an intermediate of Tetra conazole : During isagro transition period in 2001, the process from Italy was adapted to Indian plant conditions, scaled up with some modification and handed over for commercialization. This is being produced on a regular basis.7) Pyrazosulfuron ethyl : Developed a process from scratch. Process was handed over to isagro for commercialization in 2001 during hiving of the company from RPGMANY PROJECTS ON CUSTOM SYNTHESIS FOR CBZ, PFIZER, AVENTIS, ETC WERE DONE DURING THIS TENURE IN RPG LIFE SCIENCES

Milan, It

Carried out Synthetic Research work partly at (R&D) at RPG RESEARCH CENTRE NAVIMUMBAI- PLANT WAS AT PANOLI,

Paris, France, Fr

QUALITY ASSURANCE/GOOD MANUFACTURING PRACTICES1. Exposure to GMP in Bulk drugs and Formulations 2. Excellent Computer literacy. 3 Prepared Drug master files and Site master files for submission to Foreignand Local regulatory bodies. 4. Conducted Process validations of Bulk drugs. 5. Exposure to cleaning validations. 6. Reviewing of SOP's for different departments. 7. Reviewing of MFR's and BMR's 8. All aspects of documentation with respect to GMP guidelines. 9. Involved in a successful preparation for an audit by the Australianregulatory body." Therapeutic Goods Administration (TGA) " 10. Similar involvement with a WHO audit of formulations 11. Conducted several GMP audits. 12 Conducted several Vendor assessments. MANUFACTURINGPractical Production training in Pharmaceutical manufacturing in the following Departments.1. Powder injectibles 2. Large Volume Parenterals (Haemaccel) 3. Small Volume Parenterals (Liquid injectibles) 4. Tablets.

VISITED TABLETS, LARGE VOLUME PARENTERALS, INJ, STORES ETC AS PART OF GMP TRAINING

Ludwigshafen, De

CUSTOM SYNTHESIS OF API, Eg COENZYME Q10, ETC

Basel, Basel-Stadt, Ch

MANY PROJECTS ON CUSTOM SYNTHESIS FOR CBZ, PFIZER, AVENTIS, ETC WERE DONE DURING THIS TENURE IN INNOVASSYNTH

PROCESS DEVELOPMENT OF AGROCHEMICALS FOR VERY SHORT TIME SINCE THIS COMPANY WAS A SISTER CONCERN OF HOECHST MARION ROUSSEL AND REPORTED TO DR RALPH STAPEL,DIRECTOR PROCESS DEVELOPMENT(ANILOPHOS, DELTAMETHRIN, TEFURAMETHRIN)

Paris, France, Fr

MULUND, Mumbai. INDIA The job involved all aspects of synthesis and commercialization from research lab to production,PROJECTS HANDLED:1.Pentoxyfylline : Independently developed a new route 2.Roxatidine : In a team worked on some of its intermediates; Process development and production trouble Shooting 4.ECPPA : Independently developed a 5 step route for the synthesis of this single isomer (Enalapril/RamipriIntermediate) 5.Furamethrin Alc : Independently developed a commercially viable route for its manufacture involving Acetylene as the raw material. 6.Tefuramethrin : Independently developed its synthesis for M/S Diannihon Jochugiko Japan. 7. Several Drugs/ Vet.Drugs : Trouble shooting for production (eg. PitofenoneHCl, Frusemide, Ramipril, etc.)

Us

1 year 7 months, Drugs and Natural products, Dr K Nagarajan, Mrs ShenoyAzathioprine :worked on all the steps. ALSO WORKED ON CANNABINOID DRUGS, OLIVETOL, worked on menthadienol, iohexol, x ray contrast agents,

DID ORGANIC PROCESS DEVELOPMENT AS A RESEARCH FELLOW,

Mumbai, Maharashatra, In

4yearsWorked as Indian Organic; PhD programme(organic chemistry) on the topic " Synthesis of novel pyrethroids analogues". Simultaneously did project work for IOC.

Ph.D., Organic Chem.

M.Sc., Organic Chemistry

B.Sc, Chemistry

Hsc, Scaience

S.S.C, General