Amit Das Email & Phone Number

Bengaluru, Karnataka, India

Bengaluru, Karnataka, India

• Implemented advanced statistical features (1:n propensity matching, caliper selection, sub-sampling etc.) in to the Comparative Effectiveness tool for ConvergeHEALTH Miner Evidence platform.• R package modifications for implementation into different platforms (EKS, Databricks, OpenCPU).• Enabled password encryption or SSO login features, R console output capture for the R based self service apps of the platform.• Engagement with product strategy team to develop future product features and development of MVPs (ex. NLP based auto-tagging of datasets via python, assumptions plots, random index date, ability to directly export very large datasets to cloud via R, RWD auto profiling, single feature classification).• Assisting the UI and database team with mock-ups and feature explanations during planning and development stages. Assist technical writing team.• Engagement with QA and client deployment team for product functional testing and troubleshooting of deployment issues. Assistance to technical writing team for documentation.

Bengaluru, Karnataka

• Custom analysis of internal research data, plant trials data and customer data for better understanding of enzyme performance across different real-life scenario.• Built automated data ingestion and visualization pipelines to enable instant processing and outcome visualization.• Assisting scientists and plant operators with better experiment design based through data driven insights from experiments and trials.• Assisted sales and management on customer trial design based on analysis of historical data or enzyme performance (resulting ins successful customer on-boarding and publication from customer side).• Developed on the fly image analysis pipelines to extract quantitative information from fluorescence microscopic images while optimizing the overall process (>99% time reduction while eliminating human errors / variations). • Worked with management to increase penetration of digital tools and data analytics in Food & Beverages Application Research.

Hyderabad Area, India

Managing technical project operations of multiple projects in parallel - ensuring timely project delivery, task allocation and progress monitoring. Hands on technical support on demand.Development of in-silico pipeline for cell type signature identification for downstream applications like cell type deconvolution.Development of network based target discovery pipeline.Assisting management to build future team strategies.Working with the marketing team to showcase team technical capabilities and achievements.Assisting sales team to build potential workflows, timelines for prospective clients as well as explaining solution strategies and case studies to future and onboard clients.Empowering own team to progress in their own professional career in Excelra.

Hyderabad, Telangana, India

Technical project operations (client and internal projects):Identification of new-indications for existing drugs or other therapeutic compounds (drug-repurposing), Drug combination prediction and prioritization, Side effects mapping, Asset evaluation, Patient stratification, Product developmentSpecific aims: • Drug Combination prediction and prioritization using machine learning approaches and target based biology.• Patient stratification via un-supervised clustering based gene expression profile, disease prognostic markers and other variables like age, gender, mutations and similar parameters.• Mapping of drug-disease-target relationships, target prioritization, new indication prediction• Development of tools for data-visualization (networks, interactive plots, heatmaps etc.)• In-silico pipeline development for flow cytometry data analysis• Asset evaluation (including project management and product development)• Identifying adverse events for combination therapies• Improvement and maintenance of proprietary tools• Managing both open ended and fixed objective projects with regular client communication

Hyderabad, Telangana, India

Excelra was then known as Informatics division of GVK BioDevelopment of computational algorithms/scripts to facilitate drug-disease-target mapping in order to identify new indications of existing, shelved or failed compounds. Briefly a computational pipeline is built for each disease/drug using either literature mining (LM) genes or gene ontology (GO) processes to build relationships between each pair of drug and diseases. LM gens or GO processes are also used for enrichment analyses.Another aspect of my responsibility includes regular interaction with clients for presentations of work progress and future developments.

Kalyani, Nadia, Wb, India.

Ph.D. Thesis Project: In-silico characterization of FNBP4 as well as understanding its interaction with formins under physiological conditions.Achievements: 16 Publications in peer reviewed journals, 2 poster presentations, 2 platform presentations.Major objectives:Objective 1: Understanding the distribution, domain organization, sequence conserveness and evolution of formin binding protein 4.Objective 2: Structural modeling of FNBP4 WW domains and understanding of its ligand choices and its interaction with formins.Objective 3: In-silico structural and functional characterization of plant homologues of FNBP4.Objective 4: Understanding the effect of physiological conditions (presence of water, 37oC, salts etc.) on the FNBP WW-Formin interaction using Molecular Dynamics simulations.Objective 5: Analysis of structural and sequence variations of WW domains of WW domain containing FNBPs to understand their ligand choice variations.Other than these objectives, I have worked on building web-servers and protein databases using PHP and MySQL. An online tool name Intron Exon and UTR explorer (IEUe), that can extract gene element length and compositional characteristics has been built by me and is available at www.kutest.phpzilla.net/ieue/ Other activities:I have also taken active part in setting up computational facilities for Molecular Dynamics Simulations using High Performance Systems (hardware requirements, necessary storage and electric back-up management and software setup for smooth operations with minimum down time to maximize productive time).

Kolkata

Projects:-• Understanding the role of the last α-helix in human formin DAAM1 localization and hDAAM1 mediated actin dynamics regulation.• Characterization of short-FH2 region of Culex quinquefasctiatus formin DAAM2 in actin cytoskeleton organization. • Phylogenetic Analysis of WW and FF Domain Containing Formin Binding Proteins.• In-silico interaction based network mapping of huntingtin interaction.• Cloning, expression and purification of different region of hDAAM1 and Bni1.Responsibilities:-• Project designing,• Optimization of experimental procedures.• Experimental implementation,• Experimental data interpretation,• Training of junior fellows• Laboratory set up and management• Conference management

Bangalore

Project:-Screening of small molecules that inhibit the NTPase activity of Protein X. Responsibility:-Protein expression, purification, biochemical assay and screening of small molecule inhibitors to find the best efficient one.Achievement:-Co-awarded best summer-trainee.

Doctor Of Philosophy (Ph.D.), Bioinformatics

In-Silico Characterization of Formin Binding Protein 4 and its interactions with Formins.

Master Of Science (M.Sc.), Biophysics And Molecular Biology, 1St Class

Activities and Societies: Received Special Award for best poster at 10th Sir Dorabji Tata Symposium on “Codon usage analysis of highly.

Bachelor Of Science (B.Sc.), Zoology, 1St Class

Activities and Societies: College: Presidency College, Kolkata 2005 Freshers organizers, 2006 Departmental magazine team.

12Th Std, Science

Activities and Societies: 2003 Exhibition (Bio-sciences)

10Th, All

Activities and Societies: Quiz contest