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Proven leader and innovator in dynamic, fast-paced biotech and start-up environments. Strong track record of turning novel scientific concepts into successful therapeutic drug candidates and navigating through regulatory processes. Expertise in immuno-oncology, autoimmunity, RNA therapeutics, non-viral delivery to immune cells, gene editing, ex vivo cell therapy, in vivo CAR, and in vivo pharmacology (mouse, rat, NHP). Experienced in drug discovery and drug product development, adept at setting strategy and leading preclinical initiatives using disruptive technologies. Skilled problem-solver ensuring timely delivery of corporate milestones. Demonstrated ability to build and lead agile, high-performance teams, manage external collaborations, guide business development and legal strategy, and deliver impactful presentations to stakeholders. Passionate about developing scientists, promoting rigorous science, and driving innovation.
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Sr. DirectorExsilio Therapeutics Sep 2024 - Present -
Director, DiscoveryOrna Therapeutics, Inc. Dec 2020 - Nov 2023Watertown, Massachusetts, UsHired to build and lead the Immunology function and team to support drug discovery. Established proof of concept for Onra's novel synthetic circular RNA therapeutics in vivo panCAR platform in multiple hematologic malignancies. Responsible for leading discovery and early preclinical development of panCAR pipeline assets and for enabling regulatory interactions. Inventor on numerous patents to support Onra's leadership in the circular RNA therapeutics space. Responsible for scientific updates to internal and external stakeholders and scientific audiences. -
Principal Scientist In Cell Therapy, Immuno-OncologyIntellia Therapeutics, Inc. Jan 2019 - Dec 2020Cambridge, Massachusetts, Us -
Senior ScientistIntellia Therapeutics, Inc. Apr 2017 - Dec 2018Cambridge, Massachusetts, UsHired to build and Immunology Team to develop ex vivo cell therapies. Successfully developed an in vivo CRISPR/Cas9 screening platform in T cells to enable therapeutic benefit of ex vivo cell therapies in solid and hematologic malignancies. Contributed NTLA-5001 supporting early drug candidate nomination and regulatory submissions. Work has been presented at numerous external national meetings. Inventor on patents to support Inellia's leadership in the gene editing space. -
InstructorHarvard Medical School Sep 2014 - Apr 2017Boston, Ma, UsWork supported by competitive K01 NIDDK Career Development Award. Work focused on characterization of novel small molecule combinations to expand human and mouse hematopoietic stem cells, supporting intellectual property for business ventures. Led genetic reprogramming of human mature blood cells to hematopoietic stem cells (HSCs) and analyzed multi-omics data for cellular reprogramming factors. Developed advanced in vivo mouse models for stem cell research. Expertise in cloning, lentiviral transduction, in vivo syngeneic/humanized mouse models, in vitro assays for hematopoietic stem and progenitor cells, high-dimensional flow cytometry, cell sorting, and transcriptional analysis. -
Postdoctoral FellowBoston Children'S Hospital Jul 2014 - Apr 2017Boston, Ma, UsDual appointment with Instructor, Harvard Medical School. -
Postdoctoral FellowWashington University School Of Medicine In St. Louis Apr 2010 - Jul 2014St. Louis, Mo, UsAwarded a highly competitive K01 NIDDK Career Development Award. Published multiple manuscripts and presented work at national meetings. Found roles for IRF8, ADAM17, and GPR18 in hematopoietic lineage commitment and trafficking. Described a role for mitochondrial respiration in the regulation of plasma cells for to improve vaccine design. Developed genetic syngeneic and humanized mouse models to evaluate hematopoietic stem and progenitor cell biology and infectious diseases (IBD, influenza, vaccination) to test scientific hypotheses. Expertise in metabolism assays, immune assays (ELISA/ELISPOT), in vitro and in vivo stem/progenitor cell assays, cloning, flow cytometry, cell sorting, RNA-seq, DNA sequencing. -
Graduate StudentUt Southwestern Medical Center Aug 2004 - Aug 2009Dallas, Texas, UsT cell receptor signalingAuthored and contributed to several publicationsSigma Xi membership awarded for outstanding academic performance -
Research AssistantUt Southwestern Medical Center Dec 1999 - Aug 2004Dallas, Texas, Us
Amy Becker Skills
Amy Becker Education Details
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Ut Southwestern Medical CenterImmunology -
University Of North TexasBiology
Frequently Asked Questions about Amy Becker
What company does Amy Becker work for?
Amy Becker works for Exsilio Therapeutics
What is Amy Becker's role at the current company?
Amy Becker's current role is Head of T Cell Programs | Exsilio Therapeutics.
What is Amy Becker's email address?
Amy Becker's email address is am****@****atx.com
What is Amy Becker's direct phone number?
Amy Becker's direct phone number is +162065*****
What schools did Amy Becker attend?
Amy Becker attended Ut Southwestern Medical Center, University Of North Texas.
What are some of Amy Becker's interests?
Amy Becker has interest in Career, Christianity, Kids, Cooking, Exercise, Electronics, Outdoors, Sweepstakes, Home Improvement, Shooting.
What skills is Amy Becker known for?
Amy Becker has skills like Flow Cytometry, Cell Biology, Western Blotting, Immunology, Tissue Culture, Molecular Biology, Cell Culture, Animal Models, Protein Purification, Confocal Microscopy, Protein Expression, Fluorescence Microscopy.
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