Assay development and execution of biochemical high throughput screens and lead optimization:Creating, validating, troubleshooting, and generally overseeing automated workflows on state of the art High Resolution Biosciences integrated systems.Enzyme characterization and experimental parameter optimization studies in 1536 well plates.Working with informatics teams in development of data processing/analysis tools and instrumentation integration.Working closely with other departments in lead optimization efforts.Being the point person for all lab automation needs and maintenance: Responsible for all automation troubleshooting and vendor relations, scheduling field service, organizing service contracts, creating standard automation and best practices protocols.

Ran, optimized and automated molecular biology library building protocols.

May 2014-September 2016 Automation Engineer - Leader of Screening Group Horizon Discovery, Cambridge, MA● Perform primary HTS, secondary hit profiling assays using focused small molecule and antibodies for internal research and external clients● Program, operate, qualify and troubleshoot custom-integrated automation systems● Document and create technical reports/SOPs● Present data at cross-functional group meetings● In-charge of overseeing the functions of all lab automation and procurement of new lab automation● Work closely with Informatics team to develop new informatics tools for screening purposes● Manage and mentor two research associatesAug 2006-May 2014 Discovery Technologist, Discovery Sciences CombinatoRx/Zalicus, Cambridge, MA● Executed upon a large number of HTS campaigns within guidelines set forth by customer/collaborator contractual obligations resulting in ability to run screening platform up to 18 hours a day● Leadership role in design and implementation in new integrated high throughput system that resulted in a paradigm shift in the execution of high throughput screening at CombinatoRx● Participated and presented data in cross-functional group meetings● Took part in all aspects of high throughput screening campaigns from compound management, cell culture, running of automation, data QC, and secondary screening● Trained and supervised Research Associates on running and basic troubleshooting of integrated automated system

● Coordinated and ran cell-based reporter gene assays screening large small molecule libraries● Optimized assays for HTS● QC data from large screening efforts● Reformatted large small molecule libraries● Programmed and operated laboratory robotics for compound handling and cell based assays● Wrote methods for other groups utilizing the HTS equipment● Troubleshoot equipment and assays as needed● Provided tissue culture support