Postdoctoral Research Fellow
Brescia
• Designing and performing research on multiple projects related to Alpha1-antitrypsin deficiency (AATD) disease: - Expression and characterization of rare mutations of Alpha1-antitrypsin in cellular models. - Isolation and characterization of Alpha1-antitrypsin mutants from AATD patients. - Developing enzyme inhibitor activity assays for the characterization of Alpha1-antitrypsin mutants. - Production of conformation-specific monoclonal antibodies in hybridoma cells… Show more • Designing and performing research on multiple projects related to Alpha1-antitrypsin deficiency (AATD) disease: - Expression and characterization of rare mutations of Alpha1-antitrypsin in cellular models. - Isolation and characterization of Alpha1-antitrypsin mutants from AATD patients. - Developing enzyme inhibitor activity assays for the characterization of Alpha1-antitrypsin mutants. - Production of conformation-specific monoclonal antibodies in hybridoma cells, purification by affinity chromatography, and antibody conjugation with enzymatic (HRP) and fluorescent (Atto) systems.• Mentoring undergraduate students and PhD candidates• Lab management (projects coordination, material planning & ordering, instruments supervision) Show less