Andrea Floris, Phd Email & Phone Number

San Jose, California, United States

Staff scientist in R&D department new product development for SPATIAL analysis.

Los Angeles, California, United States

Research focus on profiling the post-translational modification occurring in some key proteins deregulated in breast and liver cancers.

Los Angeles, California, United States

- Proved that both SAMe and its metabolite 5-methylthioadenosine (MTA) can inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axi. - Star-related lipid transfer protein 10 (STARD10) is a novel key player in alcohol-induced breast cancer progression.- Additional project: (1) Ethanol-mediated up-regulation of CYP2E1 via SUMOylation enhances its protein stability and activity and may have important implications in Alcohol liver disease. (2) Role of TAR deoxyribonucleic acid-binding protein 43 (TDP-43) as a key protein in the pathogenesis of amyoptrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD).In addition to research, I have experience in managing a variety of research projects and multidisciplinary teams as well as mentoring medical students and junior researchers (graduate and undergraduate).

Italy

Production and characterization of lines of motor neurons originated from pluripotent stem cells (iPSC) of patients with amyotrophic lateral sclerosis:- Setup of fibroblast cultures from skin biopsies, expansion and cryopreservation. - Cell transfections of episomial vectors with lysosomes and electroporation. - Induced stem cell production (iPSC), expansion and cryopreservation. - Characterization of iPS cells by cytogenetic analysis of the karyotype and molecular analysis of gene expression by real-time PCR quantification.

Cagliari, Sardinia, Italy

- Role of KIR (Killer immunoglobulin-like receptor) genes polymorphisms in hematopoietic cell transplation from unrelated donor in B-Thalassemia.- KIR in hepatitis C virus infection and/or progression to hepatocellular carcinoma (HCC). - Role for KIR in the onset of chronic myeloid leukemia (CML) and response to therapy with tyrosine kinase inhibitors (TKIs).

Cagliari, Sardinia, Italy

Study on the variability of stem cells in amniotic fluid in relation to gestational age

Cagliari, Sardinia, Italy

Acquisition of the main prenatal diagnostic techniques:- Analysis of the amniotic fluid karyotype- Analysis of the chorionic villi karyotype- Analysis of the karyotype from abortive tissue- QF-PCR on amniotic fluid and chorionic villi- MLPA on genomic DNA extracted from amniocytes- Array-CGHPostnatal diagnostics:- Analysis of the high resolution karyotype from peripheral blood- Analysis of karyotype from solid tissue cultureOncohematology diagnostics:- Analysis of the karyotype from bone marrow aspirate- FISH (Fluorescent in Situ Hybridization) method on bone marrow aspirate- FISH method on paraffinized histological preparations

Athens, Attiki, Greece

Analyst of fetal karyotype from amniotic fluid and chorionic villus sampling

Cagliari, Sardinia, Italy

While working in the cytogenetics and molecular genetics laboratory, I developed my own project and gained experience with general lab techniques (such as RT-PCR, DNA sequencing, cell coltures ecc.).

Doctor Of Philosophy - Phd, Molecular And Translational Medicine

I attended my PhD course in Molecular Medicine at the at division of Gastroenterology department Medicine, Cedar Sinai Medical Center, Los.

Postgraduate Degree, Medical Genetics, 50/50 Summa Cum Laude

Dissertation Title: “Prenatal diagnosis of a fetus with ring chromosome 15 by array- CGH”

Master Of Science - Ms, Molecular Biology, 110/110 Summa Cum Laude

Dissertation Title: “Relationship between chromosomal aberration and ultrasonographic abnormalities in spontaneous abortion in the first.