Andrea Comba Ph.D. Email & Phone Number

Birmingham, AL, US

Birmingham, Alabama, United States

United States

Investigates the molecular basis and the cellular plasticity of the tumor microenvironment regulated by extracellular matrix changes in high-grade gliomas. Designs and executes a research project using preclinical genetic models of cancer, ex-vivo mouse tumor models, and post-operative human explant tumor models, state-of-art cellular and molecular biology.

Ann Arbor - Michigan

Held responsibility for a research project investigating tumor heterogeneity and mesenchymal transformation in brain cancer. Led the project of spatiotemporal analysis of high-grade glioma at the histological, cellular, molecular, and dynamic levels Managed the development of a spatial transcriptomic approach using laser capture microdissection and RNA-Seq.

Capital Department, Córdoba Province, Argentina

Designed and executed research studies for the investigation of the role of post-transcriptional modifications in cancer. Identified the anti-tumorigenic role of the posttranslational arginylated Calreticulin (R-CRT) in apoptosis stimulation of human glioma cancer cells under treatment with proteasomal inhibitors. Earned experience in in-vitro cell.

Capital Department, Córdoba Province, Argentina

Lead a project focused on the effects of essential fatty acids on the activity of the oncogenic factor GLI1 in breast and pancreatic adenocarcinomas. This study identified a novel anti-tumoral mechanism of essential omega-6 polyunsaturated fatty acids (PUFA) regulating the activity of the transcription factor GLI1 during carcinogenesis. PUFAs antitumoral.

Capital Department, Córdoba Province, Argentina

Instructed and taught the course Cell Biology, Histology, and Embryology to more than 100 graduate students in their Medicine careers. Prepared course materials, corrected written exams, and perform oral evaluations.

Rochester, Minnesota, United States

Earned new methodological skills in transcriptional activity and regulation analysis to apply to my Ph.D. project. Participated in a research project that studied the mechanism of the transcription factor GLI1 as a mediator of TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent.

Montevideo, Uruguay

Gained experience in single-cell sorting, flow cytometry analysis, and stable cell lines generation using fluorescent and antibiotic selection.

Rochester, Minnesota

Involved in the characterization of the molecular mechanism of the oncogenic transcription factor GLI1 in pancreatic and esophageal carcinogenesis. This study revealed a novel insight into the complex network involved in these pathologies as a new avenue for the development of therapeutic regimens. Gained deep knowledge of the molecular and biological.

Cordoba, Córdoba, Argentina

Lead a research study that demonstrated the function of essential unsaturated fatty acids derived from walnuts and peanuts seeds in the regulation of cell proliferation, cell death, metastasis, and tumor growth of breast cancer. We revealed that dietary supplementation with Walnuts and Peanuts oils enriched in omega-3 and omega-9 essential fatty acids.

Postdoctoral Research Fellow, Neuro-Oncology

Doctor Of Philosophy - Phd, Cellular And Molecular Biology

Bachelor Of Science - Bs, Biology