Andreu Bofill, Phd Email & Phone Number

Barcelona, Catalonia, Spain

Working at the ISGlobal Maternal, Child and Reproductive Health Initiative, led by Dr. Clara Menéndez. I'm involved in several clinical and implementation research projects (i.e. ICARIA or MULTIPLY), developed in Sierra Leone, Togo and Mozambique. We are mainly focused on malaria prevention in children and pregnant women.

Computational and laboratory manager, providing logistical and data management and analysis support on COVID-19 analysis.

"The impact of the human endogenous metabolome on drug pharmacology and safety"- We provided evidences that the level of affinity required by a drug to produce a therapeutic effect interacting with its primary target is related to the affinity of the native endogenous metabolite for that specific target.- This Thesis also highlights the huge implications that the human endogenous metabolome could have to assess a more realistic drug polypharmacology landscape and the risk of safety events linked to it. - We performed an analysis of natural compound pharmacology on the perspective of the endogenous metabolome and demonstrate how the endogenous human metabolome may have a key role on exogenous molecules bioactivity, offering a new useful perspective in drug efficacy and safety.Skills: Python (Pandas, Scikitlearn, scipy, StatsModels, seaborn...), MySQL, postgresql, MongoDB, Hbase; Data Analysis methods, supervised and unsupervised ML models and data visualization tools with both Python and R.Supervisor of MSc research work - "Identification of the main core chemical structures leading to bioactive small molecules"

As part of the European H2020 ESCAPE-NET Project, we investigated the risk factors and mechanisms involved in drug-induced Sudden Cardiac Arrest. With an analysis of spontaneous drug safety reports, we identified 12 drugs likely associated with sudden cardiac arrest. An exhaustive analysis of each one of them was done to find known evidences of their potential causal relation with SCA. We further explored the pharmacology of these SCA-related drugs in order to understand which are the most common mechanisms of action involved in the appearance of this event.

Barcelona, Catalonia, Spain

Providing web support for the creation and management of teaching materials for the MSc in Bioinformatics for Health Sciences.

"Impact of Small Molecules on Protein-Protein Interactions"We develop a method to study the effect that the interaction of certain small molecule with one protein has on the residues involved in the protein–protein interaction. Supervisor: Jordi Mestres.Skills: Python, Molecular visualization tools (VMD, Chimera, PyMOL), Database management, basic data analysis tools, GAPS software.

Barcelona

"Computational prediction of RNA secondary structures directing Selenocysteine incorporation in Archaea"Development of a computational tool for the prediction of selenoprotein genes in Archaea, based in the identification of the SECIS element as first step. This new archaeal SECIS model will help to predict and identify archaeal selenoprotein genes. Mentors: Roderic Guigó and Marco Mariotti.Skills: RNA sequence analysis, Inference of RNA Alignment, BLAST, multiple sequence alignments methods, Exonerate.

Doctor Of Philosophy - Phd, Biomedicine

Master Of Science - Ms, Bioinformatics For Health Sciences

Bachelor Of Science - Bs, Human Biology