Andrew Pickering Email and Phone Number

Publications:Pickering AM, Lehr M, Miller RA. (2015) Lifespan of mice and primates correlates with immunoproteasome expression.J Clin Invest. May 1;125(5):2059-68. doi: 10.1172/JCI80514. Pickering, A.M., Lehr, M., Kohler, W.J., Han, M.L., and Miller, R.A. (2014). Fibroblasts from longer lived species of primates, rodents, bats, carnivores and birds resist protein damage. J Gerontol A Biol Sci Med Sci. 2014 Jul 28. pii: glu115. Funding:F-32: Comparative Cell Biology of Aging: Proteostasis Control in Long- and Short-Lived SpeciesInstitute: National institute on Aging (NIA).PI: Andrew M. Pickering. Submitted: 04/04/2014. Funding dates: 04/01/2015 – 11/31/2017Biology of Aging T-32, Institute: University of MichiganPI: Andrew M. Pickering. Funding dates: 12/01/2014 – 03/31/2015

Publications:Pickering A M, Vojtovicha L, Tower J, Davies K J A. Oxidative Stress Adaption with Acute, Chronic and Repeated Stress. Free Radic Biol Med. 2013 Feb;55:109-18.Pickering A M, Staab T A, Tower J, Sieburth S, Davies K J A. A Conserved Role for the 20S Proteasome and Nrf2 Transcription Factor in Oxidative-Stress Adaptation in Mammals, C. elegans and D. melanogaster. J Exp Biol. 2013 Feb 15;216(Pt 4):543-53Pickering A M, Davies K J A. Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins. Arch Biochem Biophys. 2012 Jul 15;523(2):181-90.Pickering A M, Linder RA, Zhang H, Forman H J, Davies K J A. Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress. J Biol Chem. 2012 Mar 23;287(13):10021-31.Pickering A M, Davies K J A. A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis. FRBM. 2012 Vol. 52 (2), pp. 239-46Grune T, Catalgol B, Licht A, Ermak G, Pickering, A M, Ngo J K, Davies K J A. HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. FRBM. 2011 Vol. 51 (7), pp. 1355-64. Pickering, A. M, Koop A L, Teoh C Y, Ermak G, Grune T, Davies K J A. The immunoproteasome, the 20S proteasome, and the PA28aß proteasome regulator are oxidative stress-adaptive proteolytic complexes. Biochem J. 2010 Dec 15;432(3):585-94. Nuzhdin, S. V., Brisson, J. A., Pickering, A. M., Wayne, M. L., Harshman, L. G., McIntyre, L. M. Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster. BMC Genomics. 2009 Vol. 10, pp. 124. Book Chapter:Pickering A M, Davies K J A.Degradation of damaged proteins: the main function of the 20S proteasome. Prog Mol Biol Transl Sci. 2012;109:227-48