Undergraduate Researcher - Baum Laboratory
Conducted Research with Dr. Jean BaumLed research project to predict and characterize the last common synuclein ancestor.- Developed workflow for accurate ancestral sequence reconstruction of synuclein ancestors- Used computational methods to infer synuclein phylogeny and synuclein ancestral sequences- Expressed last common synuclein ancestor in vitro and characterized by ThT assay- Wrote and defended senior G.H. Cook Scholar Honors Thesis on study of ancestral synucleinSupported research project to characterize the SARS-CoV-2 spike protein.- Analyzed mutational data of SARS-CoV-2 spike protein- Modeled spike receptor binding domain (RBD) mutants using PyRosetta- Performed MD simulations of spike RBD loop regions using AMBER- Expressed spike protein in Yeast and E. coli for NMR, MS, and CD analysis
